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Review

The unfolded protein response (UPR) pathway in Cryptococcus

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Pages 341-350 | Received 09 Sep 2013, Accepted 10 Oct 2013, Published online: 18 Oct 2013

References

  • Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med 2012; 4:65rv13; http://dx.doi.org/10.1126/scitranslmed.3004404; PMID: 23253612
  • Sorrell TC. Cryptococcus neoformans variety gattii.. Med Mycol 2001; 39:155 - 68; PMID: 11346263
  • Kwon-Chung KJ, Boekhout T, Fell JW, Diaz M. Proposal to conserve the name Cryptococcus gattii against C. hondurianus and C. bacillisporus (Basidiomycota, Hymenomycetes, Tremellomycetidae). Taxon 2002; 51:804 - 6; http://dx.doi.org/10.2307/1555045
  • Byrnes EJ 3rd, Bartlett KH, Perfect JR, Heitman J. Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals. Microbes Infect 2011; 13:895 - 907; http://dx.doi.org/10.1016/j.micinf.2011.05.009; PMID: 21684347
  • Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009; 23:525 - 30; http://dx.doi.org/10.1097/QAD.0b013e328322ffac; PMID: 19182676
  • Sukroongreung S, Kitiniyom K, Nilakul C, Tantimavanich S. Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans.. Med Mycol 1998; 36:419 - 24; PMID: 10206753
  • Idnurm A, Bahn YS, Nielsen K, Lin X, Fraser JA, Heitman J. Deciphering the model pathogenic fungus Cryptococcus neoformans.. Nat Rev Microbiol 2005; 3:753 - 64; http://dx.doi.org/10.1038/nrmicro1245; PMID: 16132036
  • Vartivarian SE, Anaissie EJ, Cowart RE, Sprigg HA, Tingler MJ, Jacobson ES. Regulation of cryptococcal capsular polysaccharide by iron. J Infect Dis 1993; 167:186 - 90; http://dx.doi.org/10.1093/infdis/167.1.186; PMID: 8418165
  • Granger DL, Perfect JR, Durack DT. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J Clin Invest 1985; 76:508 - 16; http://dx.doi.org/10.1172/JCI112000; PMID: 3928681
  • Aksenov SI, Babyeva IP, Golubev VI. On the mechanism of adaptation of micro-organisms to conditions of extreme low humidity. Life Sci Space Res 1973; 11:55 - 61; PMID: 12523380
  • Bose I, Reese AJ, Ory JJ, Janbon G, Doering TL. A yeast under cover: the capsule of Cryptococcus neoformans.. Eukaryot Cell 2003; 2:655 - 63; http://dx.doi.org/10.1128/EC.2.4.655-663.2003; PMID: 12912884
  • Nosanchuk JD, Rosas AL, Lee SC, Casadevall A. Melanisation of Cryptococcus neoformans in human brain tissue. Lancet 2000; 355:2049 - 50; http://dx.doi.org/10.1016/S0140-6736(00)02356-4; PMID: 10885360
  • Casadevall A, Rosas AL, Nosanchuk JD. Melanin and virulence in Cryptococcus neoformans.. Curr Opin Microbiol 2000; 3:354 - 8; http://dx.doi.org/10.1016/S1369-5274(00)00103-X; PMID: 10972493
  • Zhu X, Williamson PR. Role of laccase in the biology and virulence of Cryptococcus neoformans.. FEMS Yeast Res 2004; 5:1 - 10; http://dx.doi.org/10.1016/j.femsyr.2004.04.004; PMID: 15381117
  • Bahn YS, Kojima K, Cox GM, Heitman J. Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans.. Mol Biol Cell 2005; 16:2285 - 300; http://dx.doi.org/10.1091/mbc.E04-11-0987; PMID: 15728721
  • Bahn YS, Geunes-Boyer S, Heitman J. Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.. Eukaryot Cell 2007; 6:2278 - 89; http://dx.doi.org/10.1128/EC.00349-07; PMID: 17951522
  • Kronstad JW, Hu G, Choi J. The cAMP/protein kinase A pathway and virulence in Cryptococcus neoformans.. Mycobiology 2011; 39:143 - 50; http://dx.doi.org/10.5941/MYCO.2011.39.3.143; PMID: 22783095
  • Alspaugh JA, Perfect JR, Heitman J. Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.. Fungal Genet Biol 1998; 25:1 - 14; http://dx.doi.org/10.1006/fgbi.1998.1079; PMID: 9806801
  • Kraus PR, Heitman J. Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem Biophys Res Commun 2003; 311:1151 - 7; http://dx.doi.org/10.1016/S0006-291X(03)01528-6; PMID: 14623301
  • Kraus PR, Nichols CB, Heitman J. Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth. Eukaryot Cell 2005; 4:1079 - 87; http://dx.doi.org/10.1128/EC.4.6.1079-1087.2005; PMID: 15947200
  • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8:519 - 29; http://dx.doi.org/10.1038/nrm2199; PMID: 17565364
  • Lin JH, Walter P, Yen TS. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol 2008; 3:399 - 425; http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.151434; PMID: 18039139
  • Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008; 454:455 - 62; http://dx.doi.org/10.1038/nature07203; PMID: 18650916
  • Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 2000; 101:249 - 58; http://dx.doi.org/10.1016/S0092-8674(00)80835-1; PMID: 10847680
  • Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem 2006; 281:5852 - 60; http://dx.doi.org/10.1074/jbc.M509061200; PMID: 16332684
  • Yoshida H, Oku M, Suzuki M, Mori K. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol 2006; 172:565 - 75; http://dx.doi.org/10.1083/jcb.200508145; PMID: 16461360
  • Liu J-X, Howell SH. Endoplasmic reticulum protein quality control and its relationship to environmental stress responses in plants. Plant Cell 2010; 22:2930 - 42; http://dx.doi.org/10.1105/tpc.110.078154; PMID: 20876830
  • Deng Y, Humbert S, Liu JX, Srivastava R, Rothstein SJ, Howell SH. Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis. Proc Natl Acad Sci U S A 2011; 108:7247 - 52; http://dx.doi.org/10.1073/pnas.1102117108; PMID: 21482766
  • Cox JS, Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 1996; 87:391 - 404; http://dx.doi.org/10.1016/S0092-8674(00)81360-4; PMID: 8898193
  • Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 1997; 90:1031 - 9; http://dx.doi.org/10.1016/S0092-8674(00)80369-4; PMID: 9323131
  • Rüegsegger U, Leber JH, Walter P. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell 2001; 107:103 - 14; http://dx.doi.org/10.1016/S0092-8674(01)00505-0; PMID: 11595189
  • Oh MH, Cheon SA, Kang HA, Kim JY. Functional characterization of the unconventional splicing of Yarrowia lipolytica HAC1 mRNA induced by unfolded protein response. Yeast 2010; 27:443 - 52; http://dx.doi.org/10.1002/yea.1762; PMID: 20162530
  • Richie DL, Hartl L, Aimanianda V, Winters MS, Fuller KK, Miley MD, White S, McCarthy JW, Latgé JP, Feldmesser M, et al. A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus.. PLoS Pathog 2009; 5:e1000258; http://dx.doi.org/10.1371/journal.ppat.1000258; PMID: 19132084
  • Wimalasena TT, Enjalbert B, Guillemette T, Plumridge A, Budge S, Yin Z, Brown AJ, Archer DB. Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans.. Fungal Genet Biol 2008; 45:1235 - 47; http://dx.doi.org/10.1016/j.fgb.2008.06.001; PMID: 18602013
  • Joubert A, Simoneau P, Campion C, Bataillé-Simoneau N, Iacomi-Vasilescu B, Poupard P, François JM, Georgeault S, Sellier E, Guillemette T. Impact of the unfolded protein response on the pathogenicity of the necrotrophic fungus Alternaria brassicicola.. Mol Microbiol 2011; 79:1305 - 24; http://dx.doi.org/10.1111/j.1365-2958.2010.07522.x; PMID: 21251090
  • Hooks KB, Griffiths-Jones S. Conserved RNA structures in the non-canonical Hac1/Xbp1 intron. RNA Biol 2011; 8:552 - 6; http://dx.doi.org/10.4161/rna.8.4.15396; PMID: 21593604
  • Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife 2012; 1:e00048; http://dx.doi.org/10.7554/eLife.00048; PMID: 23066505
  • Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H, Kohno S. Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata.. PLoS Pathog 2013; 9:e1003160; http://dx.doi.org/10.1371/journal.ppat.1003160; PMID: 23382685
  • Hollien J. Evolution of the unfolded protein response. Biochim Biophys Acta 2013; 1833:2458 - 63; http://dx.doi.org/10.1016/j.bbamcr.2013.01.016; PMID: 23369734
  • Joyce BR, Tampaki Z, Kim K, Wek RC, Sullivan WJ Jr.. The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control. Eukaryot Cell 2013; 12:979 - 89; http://dx.doi.org/10.1128/EC.00021-13; PMID: 23666622
  • Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA. Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans.. PLoS Pathog 2011; 7:e1002177; http://dx.doi.org/10.1371/journal.ppat.1002177; PMID: 21852949
  • Saloheimo M, Valkonen M, Penttilä M. Activation mechanisms of the HAC1-mediated unfolded protein response in filamentous fungi. Mol Microbiol 2003; 47:1149 - 61; http://dx.doi.org/10.1046/j.1365-2958.2003.03363.x; PMID: 12581366
  • Jung KW, Kang HA, Bahn YS. Essential roles of the Kar2/BiP molecular chaperone downstream of the UPR pathway in Cryptococcus neoformans.. PLoS One 2013; 8:e58956; http://dx.doi.org/10.1371/journal.pone.0058956; PMID: 23484059
  • Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002; 415:92 - 6; http://dx.doi.org/10.1038/415092a; PMID: 11780124
  • Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 2006; 22:487 - 508; http://dx.doi.org/10.1146/annurev.cellbio.21.122303.120200; PMID: 16822172
  • Mulder HJ, Saloheimo M, Penttilä M, Madrid SM. The transcription factor HACA mediates the unfolded protein response in Aspergillus niger, and up-regulates its own transcription. Mol Genet Genomics 2004; 271:130 - 40; http://dx.doi.org/10.1007/s00438-003-0965-5; PMID: 14730445
  • Shen X, Ellis RE, Sakaki K, Kaufman RJ. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.. PLoS Genet 2005; 1:e37; http://dx.doi.org/10.1371/journal.pgen.0010037; PMID: 16184190
  • Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, et al. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.. PLoS Pathog 2011; 7:e1002330; http://dx.doi.org/10.1371/journal.ppat.1002330; PMID: 22028661
  • Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol 2009; 186:323 - 31; http://dx.doi.org/10.1083/jcb.200903014; PMID: 19651891
  • Hollien J, Weissman JS. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 2006; 313:104 - 7; http://dx.doi.org/10.1126/science.1129631; PMID: 16825573
  • Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012; 13:89 - 102; PMID: 22251901
  • Scrimale T, Didone L, de Mesy Bentley KL, Krysan DJ. The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae.. Mol Biol Cell 2009; 20:164 - 75; http://dx.doi.org/10.1091/mbc.E08-08-0809; PMID: 18971375
  • Blankenship JR, Fanning S, Hamaker JJ, Mitchell AP. An extensive circuitry for cell wall regulation in Candida albicans.. PLoS Pathog 2010; 6:e1000752; http://dx.doi.org/10.1371/journal.ppat.1000752; PMID: 20140194
  • Chen YL, Lehman VN, Lewit Y, Averette AF, Heitman J. Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. G3 (Bethesda) 2013; 3:527 - 39; http://dx.doi.org/10.1534/g3.112.004242; PMID: 23450261
  • Havel VE, Wool NK, Ayad D, Downey KM, Wilson CF, Larsen P, Djordjevic JT, Panepinto JC. Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans.. Eukaryot Cell 2011; 10:895 - 901; http://dx.doi.org/10.1128/EC.00006-11; PMID: 21602483
  • Bloom AL, Solomons JT, Havel VE, Panepinto JC. Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans.. Mol Microbiol 2013; 89:65 - 83; http://dx.doi.org/10.1111/mmi.12258; PMID: 23659661
  • Kathiravan MK, Salake AB, Chothe AS, Dudhe PB, Watode RP, Mukta MS, Gadhwe S. The biology and chemistry of antifungal agents: a review. Bioorg Med Chem 2012; 20:5678 - 98; http://dx.doi.org/10.1016/j.bmc.2012.04.045; PMID: 22902032
  • Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell 2010; 38:291 - 304; http://dx.doi.org/10.1016/j.molcel.2010.04.001; PMID: 20417606
  • Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol 2011; 9:48; http://dx.doi.org/10.1186/1741-7007-9-48; PMID: 21729334
  • Pal B, Chan NC, Helfenbaum L, Tan K, Tansey WP, Gething MJ. SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae.. Mol Biol Cell 2007; 18:426 - 40; http://dx.doi.org/10.1091/mbc.E06-04-0304; PMID: 17108329
  • Grigoriev IV, Nordberg H, Shabalov I, Aerts A, Cantor M, Goodstein D, Kuo A, Minovitsky S, Nikitin R, Ohm RA, et al. The genome portal of the Department of Energy Joint Genome Institute. Nucleic Acids Res 2012; 40:Database issue D26 - 32; http://dx.doi.org/10.1093/nar/gkr947; PMID: 22110030