Looking through a cranial window

References

• World Health Organization. World malaria report 2010. Geneva, Switzerland: World Health Organization; 2010. Available at http://www.who.int/malaria/world_malaria_report_2010/en/index.html.
   Google Scholar
• Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005; 434:214 - 7; http://dx.doi.org/10.1038/nature03342; PMID: 15759000
   PubMed Web of Science ®Google Scholar
• Schofield L, Grau GE. Immunological processes in malaria pathogenesis. Nat Rev Immunol 2005; 5:722 - 35; http://dx.doi.org/10.1038/nri1686; PMID: 16138104
   PubMed Web of Science ®Google Scholar
• Desruisseaux MS, Machado FS, Weiss LM, Tanowitz HB, Golightly LM. Cerebral malaria: a vasculopathy. Am J Pathol 2010; 176:1075 - 8; http://dx.doi.org/10.2353/ajpath.2010.091090; PMID: 20093501
   PubMed Web of Science ®Google Scholar
• Dondorp AM, Lee SJ, Faiz MA, Mishra S, Price R, Tjitra E, Than M, Htut Y, Mohanty S, Yunus EB, et al. The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis 2008; 47:151 - 7; http://dx.doi.org/10.1086/589287; PMID: 18533842
   PubMed Web of Science ®Google Scholar
• Boivin MJ. Effects of early cerebral malaria on cognitive ability in Senegalese children. J Dev Behav Pediatr 2002; 23:353 - 64; http://dx.doi.org/10.1097/00004703-200210000-00010; PMID: 12394524
   PubMed Web of Science ®Google Scholar
• Boivin MJ, Gladstone MJ, Vokhiwa M, Birbeck GL, Magen JG, Page C, Semrud-Clikeman M, Kauye F, Taylor TE. Developmental outcomes in Malawian children with retinopathy-positive cerebral malaria. Trop Med Int Health 2011; 16:263 - 71; http://dx.doi.org/10.1111/j.1365-3156.2010.02704.x; PMID: 21143354
   PubMed Web of Science ®Google Scholar
• Carter JA, Ross AJ, Neville BG, Obiero E, Katana K, Mung’ala-Odera V, Lees JA, Newton CR. Developmental impairments following severe falciparum malaria in children. Trop Med Int Health 2005; 10:3 - 10; http://dx.doi.org/10.1111/j.1365-3156.2004.01345.x; PMID: 15655008
   PubMed Web of Science ®Google Scholar
• Aikawa M, Iseki M, Barnwell JW, Taylor D, Oo MM, Howard RJ. The pathology of human cerebral malaria. Am J Trop Med Hyg 1990; 43:30 - 7; PMID: 2202227
   PubMed Web of Science ®Google Scholar
• Turner GD, Morrison H, Jones M, Davis TM, Looareesuwan S, Buley ID, Gatter KC, Newbold CI, Pukritayakamee S, Nagachinta B, et al. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol 1994; 145:1057 - 69; PMID: 7526692
   PubMed Web of Science ®Google Scholar
• Ahlqvist J. Decreased red cell deformability and vascular obstruction in falciparum malaria illustrated by a fatal case. Scand J Haematol 1985; 35:531 - 5; http://dx.doi.org/10.1111/j.1600-0609.1985.tb02824.x; PMID: 3911374
   PubMedGoogle Scholar
• Adams S, Brown H, Turner G. Breaking down the blood-brain barrier: signaling a path to cerebral malaria?. Trends Parasitol 2002; 18:360 - 6; http://dx.doi.org/10.1016/S1471-4922(02)02353-X; PMID: 12377286
   PubMed Web of Science ®Google Scholar
• Rénia L, Howland SW, Claser C, Charlotte Gruner A, Suwanarusk R, Hui Teo T, Russell B, Ng LF. Cerebral malaria: mysteries at the blood-brain barrier. Virulence 2012; 3:193 - 201; http://dx.doi.org/10.4161/viru.19013; PMID: 22460644
   PubMed Web of Science ®Google Scholar
• Newton CR, Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther 1998; 79:1 - 53; http://dx.doi.org/10.1016/S0163-7258(98)00008-4; PMID: 9719344
   PubMed Web of Science ®Google Scholar
• Medana IM, Day NP, Hien TT, Mai NT, Bethell D, Phu NH, Farrar J, Esiri MM, White NJ, Turner GD. Axonal injury in cerebral malaria. Am J Pathol 2002; 160:655 - 66; http://dx.doi.org/10.1016/S0002-9440(10)64885-7; PMID: 11839586
   PubMed Web of Science ®Google Scholar
• Dorovini-Zis K, Schmidt K, Huynh H, Fu W, Whitten RO, Milner D, Kamiza S, Molyneux M, Taylor TE. The neuropathology of fatal cerebral malaria in malawian children. Am J Pathol 2011; 178:2146 - 58; http://dx.doi.org/10.1016/j.ajpath.2011.01.016; PMID: 21514429
   PubMed Web of Science ®Google Scholar
• Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit M, Allan R, Brewster DR, Grau GE, et al. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med 1993; 86:91 - 8; PMID: 8329024
   PubMedGoogle Scholar
• Crawley J, Waruiru C, Mithwani S, Mwangi I, Watkins W, Ouma D, Winstanley P, Peto T, Marsh K. Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. Lancet 2000; 355:701 - 6; http://dx.doi.org/10.1016/S0140-6736(99)07148-2; PMID: 10703801
   PubMed Web of Science ®Google Scholar
• Langhorne J, Buffet P, Galinski M, Good M, Harty J, Leroy D, Mota MM, Pasini E, Renia L, Riley E, et al. The relevance of non-human primate and rodent malaria models for humans. Malar J 2011; 10:23; http://dx.doi.org/10.1186/1475-2875-10-23; PMID: 21288352
   PubMed Web of Science ®Google Scholar
• Hunt NH, Grau GE. Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 2003; 24:491 - 9; http://dx.doi.org/10.1016/S1471-4906(03)00229-1; PMID: 12967673
   PubMed Web of Science ®Google Scholar
• Hansen DS. Inflammatory responses associated with the induction of cerebral malaria: lessons from experimental murine models. PLoS Pathog 2012; 8:e1003045; http://dx.doi.org/10.1371/journal.ppat.1003045; PMID: 23300435
   PubMedGoogle Scholar
• Cabrales P, Zanini GM, Meays D, Frangos JA, Carvalho LJ. Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. Am J Pathol 2010; 176:1306 - 15; http://dx.doi.org/10.2353/ajpath.2010.090691; PMID: 20110412
   PubMed Web of Science ®Google Scholar
• El-Assaad F, Wheway J, Mitchell AJ, Lou J, Hunt NH, Combes V, Grau GE. Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infect Immun 2013; 81:3984 - 91; http://dx.doi.org/10.1128/IAI.00428-13; PMID: 23940206
   PubMed Web of Science ®Google Scholar
• Cabrales P, Carvalho LJ. Intravital microscopy of the mouse brain microcirculation using a closed cranial window. J Vis Exp 2010; 45:2184; PMID: 21113121
   PubMedGoogle Scholar
• Ong PK, Meays D, Frangos JA, Carvalho LJ. A chronic scheme of cranial window preparation to study pial vascular reactivity in murine cerebral malaria. Microcirculation 2013; 20:394 - 404; http://dx.doi.org/10.1111/micc.12034; PMID: 23279271
   PubMed Web of Science ®Google Scholar
• Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 2000; 20:131 - 47; http://dx.doi.org/10.1023/A:1007074420772; PMID: 10696506
   PubMed Web of Science ®Google Scholar
• Cabrales P, Zanini GM, Meays D, Frangos JA, Carvalho LJ. Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. J Infect Dis 2011; 203:1454 - 63; http://dx.doi.org/10.1093/infdis/jir058; PMID: 21415018
   PubMed Web of Science ®Google Scholar
• Ong PK, Melchior B, Martins YC, Hofer A, Orjuela-Sánchez P, Cabrales P, Zanini GM, Frangos JA, Carvalho LJ. Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria. PLoS Pathog 2013; 9:e1003444; http://dx.doi.org/10.1371/journal.ppat.1003444; PMID: 23818850
   PubMed Web of Science ®Google Scholar
• Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, McNeil YR, Darcy CJ, Granger DL, Weinberg JB, Lopansri BK, et al. Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. J Exp Med 2007; 204:2693 - 704; http://dx.doi.org/10.1084/jem.20070819; PMID: 17954570
   PubMed Web of Science ®Google Scholar
• Zanini GM, Cabrales P, Barkho W, Frangos JA, Carvalho LJ. Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice. J Neuroinflammation 2011; 8:66; http://dx.doi.org/10.1186/1742-2094-8-66; PMID: 21649904
   PubMed Web of Science ®Google Scholar
• Penet MF, Viola A, Confort-Gouny S, Le Fur Y, Duhamel G, Kober F, Ibarrola D, Izquierdo M, Coltel N, Gharib B, et al. Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema. J Neurosci 2005; 25:7352 - 8; http://dx.doi.org/10.1523/JNEUROSCI.1002-05.2005; PMID: 16093385
   PubMed Web of Science ®Google Scholar
• Beare NA, Lewis DK, Kublin JG, Harding SP, Zijlstra EE, Molyneux ME. Retinal changes in adults with cerebral malaria. Ann Trop Med Parasitol 2003; 97:313 - 5; http://dx.doi.org/10.1179/000349803235001859; PMID: 12803862
   PubMed Web of Science ®Google Scholar
• Dondorp AM, Ince C, Charunwatthana P, Hanson J, van Kuijen A, Faiz MA, Rahman MR, Hasan M, Bin Yunus E, Ghose A, et al. Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J Infect Dis 2008; 197:79 - 84; http://dx.doi.org/10.1086/523762; PMID: 18171289
   PubMed Web of Science ®Google Scholar
• Cabrales P, Martins YC, Ong PK, Zanini GM, Frangos JA, Carvalho LJ. Cerebral tissue oxygenation impairment during experimental cerebral malaria. Virulence 2013; 4:686 - 97; http://dx.doi.org/10.4161/viru.26348; PMID: 24128424
   PubMed Web of Science ®Google Scholar
• Cabrales P, Nacharaju P, Manjula BN, Tsai AG, Acharya SA, Intaglietta M. Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders. Shock 2005; 24:66 - 73; http://dx.doi.org/10.1097/01.shk.0000167111.80753.ef; PMID: 15988323
   PubMed Web of Science ®Google Scholar
• Sanni LA, Rae C, Maitland A, Stocker R, Hunt NH. Is ischemia involved in the pathogenesis of murine cerebral malaria?. Am J Pathol 2001; 159:1105 - 12; http://dx.doi.org/10.1016/S0002-9440(10)61786-5; PMID: 11549603
   PubMed Web of Science ®Google Scholar
• Rae C, McQuillan JA, Parekh SB, Bubb WA, Weiser S, Balcar VJ, Hansen AM, Ball HJ, Hunt NH. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. FASEB J 2004; 18:499 - 510; http://dx.doi.org/10.1096/fj.03-0543com; PMID: 15003995
   PubMed Web of Science ®Google Scholar