Differentiating Stem Cells into Liver

References

• Azuma , H. , Paulk , N. , Ranade , A. , Dorrell , C. , Al-Dhalimy , M. , Ellis , E. , Strom , S. , Kay , M. A. , Finegold , M. and Grompe , M. 2007 . Robust expansion of human hepatocytes in Fah(-/-)/Rag2(-/-)/Il2rg(-/-) mice . Nat Biotechnol , 25 : 903 – 10 .
   PubMed Web of Science ®Google Scholar
• Baijal , P. K. , Fitzpatrick , D. W. and Bird , R. P. 1997 . Phenobarbital and 3-methylcholanthrene treatment alters phase I and II enzymes and the sensitivity of the rat colon to the carcinogenic activity of azoxymethane . Food Chem Toxicol , 35 : 789 – 98 .
   PubMed Web of Science ®Google Scholar
• Bhatia , S. N. , Balis , U. J. , Yarmush , M. L. and Toner , M. 1999 . Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells . Faseb J , 13 : 1883 – 900 .
   PubMed Web of Science ®Google Scholar
• Cai , J. , Zhao , Y. , Liu , Y. , Ye , F. , Song , Z. , Qin , H. , Meng , S. , Chen , Y. , Zhou , R. , Song , X. , Guo , Y. , Ding , M. and Deng , H. 2007 . Directed differentiation of human embryonic stem cells into functional hepatic cells . Hepatology , 45 : 1229 – 39 .
   PubMed Web of Science ®Google Scholar
• Cho , C. H. , Parashurama , N. , Park , E. Y. , Suganuma , K. , Nahmias , Y. , Park , J. , Tilles , A. W. , Berthiaume , F. and Yarmush , M. L. 2007 . Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure . Faseb J ,
   Google Scholar
• Cirillo , L. A. , Lin , F. R. , Cuesta , I. , Friedman , D. , Jarnik , M. and Zaret , K. S. 2002 . Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4 . Mol Cell , 9 : 279 – 89 .
   PubMed Web of Science ®Google Scholar
• Cleaver , O. and Melton , D. A. 2003 . Endothelial signaling during development . Nat Med , 9 : 661 – 8 .
   PubMed Web of Science ®Google Scholar
• Clotman , F. , Jacquemin , P. , Plumb-Rudewiez , N. , Pierreux , C. E. , Van der Smissen , P. , Dietz , H. C. , Courtoy , P. J. , Rousseau , G. G. and Lemaigre , F. P. 2005 . Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors . Genes Dev , 19 : 1849 – 54 .
   PubMedGoogle Scholar
• D'Amour , K. A. , Agulnick , A. D. , Eliazer , S. , Kelly , O. G. , Kroon , E. and Baetge , E. E. 2005 . Efficient differentiation of human embryonic stem cells to definitive endoderm . Nat Biotechnol , 23 : 1534 – 41 .
   PubMed Web of Science ®Google Scholar
• D'Amour , K. A. , Bang , A. G. , Eliazer , S. , Kelly , O. G. , Agulnick , A. D. , Smart , N. G. , Moorman , M. A. , Kroon , E. , Carpenter , M. K. and Baetge , E. E. 2006 . Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells . Nat Biotechnol , 24 : 1392 – 401 .
   PubMed Web of Science ®Google Scholar
• Duncan , S. A. , Navas , M. A. , Dufort , D. , Rossant , J. and Stoffel , M. 1998 . Regulation of a transcription factor network required for differentiation and metabolism . Science , 281 : 692 – 5 .
   PubMed Web of Science ®Google Scholar
• Fair , J. H. , Cairns , B. A. , Lapaglia , M. , Wang , J. , Meyer , A. A. , Kim , H. , Hatada , S. , Smithies , O. and Pevny , L. 2003 . Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm . Surgery , 134 : 189 – 96 .
   PubMedGoogle Scholar
• Fisher , R. A. and Strom , S. C. 2006 . Human hepatocyte transplantation: worldwide results . Transplantation , 82 : 441 – 9 .
   PubMed Web of Science ®Google Scholar
• Fox , I. J. , Chowdhury , J. R. , Kaufman , S. S. , Goertzen , T. C. , Chowdhury , N. R. , Warkentin , P. I. , Dorko , K. , Sauter , B. V. and Strom , S. C. 1998 . Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation . N Engl J Med , 338 : 1422 – 6 .
   PubMed Web of Science ®Google Scholar
• Germain , L. , Blouin , M. J. and Marceau , N. 1988 . Biliary epithelial and hepatocytic cell lineage relationships in embryonic rat liver as determined by the differential expression of cytokeratins, alpha-fetoprotein, albumin, and cell surface-exposed components . Cancer Res , 48 : 4909 – 18 .
   PubMed Web of Science ®Google Scholar
• Gouon-Evans , V. , Boussemart , L. , Gadue , P. , Nierhoff , D. , Koehler , C. I. , Kubo , A. , Shafritz , D. A. and Keller , G. 2006 . BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm . Nat Biotechnol , 24 : 1402 – 11 .
   PubMed Web of Science ®Google Scholar
• Griffith , L. G. and Swartz , M. A. 2006 . Capturing complex 3D tissue physiology in vitro . Nat Rev Mol Cell Biol , 7 : 211 – 24 .
   PubMed Web of Science ®Google Scholar
• Gualdi , R. , Bossard , P. , Zheng , M. , Hamada , Y. , Coleman , J. R. and Zaret , K. S. 1996 . Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control . Genes Dev , 10 : 1670 – 82 .
   PubMed Web of Science ®Google Scholar
• Hamazaki , T. , Iiboshi , Y. , Oka , M. , Papst , P. J. , Meacham , A. M. , Zon , L. I. and Terada , N. 2001 . Hepatic maturation in differentiating embryonic stem cells in vitro . FEBS Lett , 497 : 15 – 9 .
   PubMed Web of Science ®Google Scholar
• Hay , D. C. , Zhao , D. , Ross , A. , Mandalam , R. , Lebkowski , J. and Cui , W. 2007 . Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities . Cloning Stem Cells , 9 : 51 – 62 .
   PubMedGoogle Scholar
• Hewitt , N. J. , Lechon , M. J. , Houston , J. B. , Hallifax , D. , Brown , H. S. , Maurel , P. , Kenna , J. G. , Gustavsson , L. , Lohmann , C. , Skonberg , C. , Guillouzo , A. , Tuschl , G. , Li , A. P. , LeCluyse , E. , Groothuis , G. M. and Hengstler , J. G. 2007 . Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies . Drug Metab Rev , 39 : 159 – 234 .
   PubMed Web of Science ®Google Scholar
• Itskovitz-Eldor , J. , Schuldiner , M. , Karsenti , D. , Eden , A. , Yanuka , O. , Amit , M. , Soreq , H. and Benvenisty , N. 2000 . Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers . Mol Med , 6 : 88 – 95 .
   PubMed Web of Science ®Google Scholar
• Jung , J. , Zheng , M. , Goldfarb , M. and Zaret , K. S. 1999 . Initiation of mammalian liver development from endoderm by fibroblast growth factors . Science , 284 : 1998 – 2003 .
   PubMed Web of Science ®Google Scholar
• Kim , J. H. , Auerbach , J. M. , Rodriguez-Gomez , J. A. , Velasco , I. , Gavin , D. , Lumelsky , N. , Lee , S. H. , Nguyen , J. , Sanchez-Pernaute , R. , Bankiewicz , K. and McKay , R. 2002 . Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease . Nature , 418 : 50 – 6 .
   PubMed Web of Science ®Google Scholar
• Kodama , Y. , Hijikata , M. , Kageyama , R. , Shimotohno , K. and Chiba , T. 2004 . The role of notch signaling in the development of intrahepatic bile ducts . Gastroenterology , 127 : 1775 – 86 .
   PubMed Web of Science ®Google Scholar
• Kostrubsky , V. E. , Ramachandran , V. , Venkataramanan , R. , Dorko , K. , Esplen , J. E. , Zhang , S. , Sinclair , J. F. , Wrighton , S. A. and Strom , S. C. 1999 . The use of human hepatocyte cultures to study the induction of cytochrome P-450 . Drug Metab Dispos , 27 : 887 – 94 .
   PubMed Web of Science ®Google Scholar
• Krupczak-Hollis , K. , Wang , X. , Kalinichenko , V. V. , Gusarova , G. A. , Wang , I. C. , Dennewitz , M. B. , Yoder , H. M. , Kiyokawa , H. , Kaestner , K. H. and Costa , R. H. 2004 . The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis . Dev Biol , 276 : 74 – 88 .
   PubMed Web of Science ®Google Scholar
• Kubo , A. , Shinozaki , K. , Shannon , J. M. , Kouskoff , V. , Kennedy , M. , Woo , S. , Fehling , H. J. and Keller , G. 2004 . Development of definitive endoderm from embryonic stem cells in culture . Development , 131 : 1651 – 62 .
   PubMed Web of Science ®Google Scholar
• Lavon , N. , Yanuka , O. and Benvenisty , N. 2004 . Differentiation and isolation of hepatic-like cells from human embryonic stem cells . Differentiation , 72 : 230 – 8 .
   PubMed Web of Science ®Google Scholar
• Lee , W. M. 1993 . Acute liver failure . N Engl J Med , 329 : 1862 – 72 .
   PubMed Web of Science ®Google Scholar
• Li , Y. C. , Wang , D. P. and Chiang , J. Y. 1990 . Regulation of cholesterol 7 alphahydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alphahydroxylase mRNA . J Biol Chem , 265 : 12012 – 9 .
   PubMed Web of Science ®Google Scholar
• Matsumoto , K. , Yoshitomi , H. , Rossant , J. and Zaret , K. S. 2001 . Liver organogenesis promoted by endothelial cells prior to vascular function . Science , 294 : 559 – 63 .
   PubMed Web of Science ®Google Scholar
• McNeish , J. 2004 . Embryonic stem cells in drug discovery . Nat Rev Drug Discov , 3 : 70 – 80 .
   PubMed Web of Science ®Google Scholar
• Mita , S. , Suzuki , H. , Akita , H. , Hayashi , H. , Onuki , R. , Hofmann , A. F. and Sugiyama , Y. 2006 . Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs . Drug Metab Dispos , 34 : 1575 – 81 .
   PubMed Web of Science ®Google Scholar
• Nagata , H. , Nishitai , R. , Shirota , C. , Zhang , J. L. , Koch , C. A. , Cai , J. , Awwad , M. , Schuurman , H. J. , Christians , U. , Abe , M. , Baranowska-Kortylewicz , J. , Platt , J. L. and Fox , I. J. 2007 . Prolonged survival of porcine hepatocytes in cynomolgus monkeys . Gastroenterology , 132 : 321 – 9 .
   PubMed Web of Science ®Google Scholar
• Nahmias , Y. , Berthiaume , F. and Yarmush , M. L. 2007 . Integration of technologies for hepatic tissue engineering . Adv Biochem Eng Biotechnol , 103 : 309 – 29 .
   PubMed Web of Science ®Google Scholar
• Navarro-Alvarez , N. , Soto-Gutierrez , A. and Kobayashi , N. 2007 . Hepatocyte transplantation: a step forward . Curr Opin Organ Transplant , 12 : 652 – 658 .
   Google Scholar
• Navarro-Alvarez , N. , Soto-Gutierrez , A. , Rivas-Carrillo , J. D. , Fox , I. J. and Kobayashi , N. 2006 . Stem cell-derived hepatocytes . Curr Opin Organ Transplant , 11 : 659 – 664 .
   Google Scholar
• Nussbaum , J. , Minami , E. , Laflamme , M. A. , Virag , J. A. , Ware , C. B. , Masino , A. , Muskheli , V. , Pabon , L. , Reinecke , H. and Murry , C. E. 2007 . Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response . Faseb J , 21 : 1345 – 57 .
   PubMed Web of Science ®Google Scholar
• Parashurama , N. , Nahmias , Y. , Cho , C. H. , van Poll , D. , Tilles , A. W. , Berthiaume , F. and Yarmush , M. L. 2007 . Activin Alters the Kinetics of Endoderm Induction in Embryonic Stem Cells Cultured on Collagen Gels . Stem Cells ,
   PubMedGoogle Scholar
• Pouton , C. W. and Haynes , J. M. 2007 . Embryonic stem cells as a source of models for drug discovery . Nat Rev Drug Discov , 6 : 605 – 16 .
   PubMed Web of Science ®Google Scholar
• Rambhatla , L. , Chiu , C. P. , Kundu , P. , Peng , Y. and Carpenter , M. K. 2003 . Generation of hepatocyte-like cells from human embryonic stem cells . Cell Transplant , 12 : 1 – 11 .
   PubMed Web of Science ®Google Scholar
• Reimold , A. M. , Etkin , A. , Clauss , I. , Perkins , A. , Friend , D. S. , Zhang , J. , Horton , H. F. , Scott , A. , Orkin , S. H. , Byrne , M. C. , Grusby , M. J. and Glimcher , L. H. 2000 . An essential role in liver development for transcription factor XBP-1 . Genes Dev , 14 : 152 – 7 .
   PubMed Web of Science ®Google Scholar
• Rossi , J. D. , Hogan , NR. , Zaret , BL. and KS. 2001 . Distinct mesodermal signals, including BMPs from the septum transversum mesenquyme, are require in combination for hepatogenesis from the endoderm . Genes Dev , 15 : 1998 – 2001 .
   PubMed Web of Science ®Google Scholar
• Runge , D. , Runge , D. M. , Jager , D. , Lubecki , K. A. , Beer Stolz , D. , Karathanasis , S. , Kietzmann , T. , Strom , S. C. , Jungermann , K. , Fleig , W. E. and Michalopoulos , G. K. 2000 . Serum-free, long-term cultures of human hepatocytes: maintenance of cell morphology, transcription factors, and liver-specific functions . Biochem Biophys Res Commun , 269 : 46 – 53 .
   PubMed Web of Science ®Google Scholar
• Sherwood , R. I. , Jitianu , C. , Cleaver , O. , Shaywitz , D. A. , Lamenzo , J. O. , Chen , A. E. , Golub , T. R. and Melton , D. A. 2007 . Prospective isolation and global gene expression analysis of definitive and visceral endoderm . Dev Biol , 304 : 541 – 55 .
   PubMedGoogle Scholar
• Soto-Gutierrez , A. , Navarro-Alvarez , N. , Rivas-Carrillo , J. D. , Chen , Y. , Yamatsuji , T. , Tanaka , N. and Kobayashi , N. 2006 . Differentiation of human embryonic stem cells to hepatocytes using deleted variant of HGF and poly-amino-urethane-coated nonwoven polytetrafluoroethylene fabric . Cell Transplant , 15 : 335 – 41 .
   PubMedGoogle Scholar
• Soto-Gutierrez , A. , Navarro-Alvarez , N. , Zhao , D. , Rivas-Carrillo , J. D. , Lebkowski , J. , Tanaka , N. , Fox , I. J. and Kobayashi , N. 2007 . Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines . Nat Protoc , 2 : 347 – 56 .
   PubMedGoogle Scholar
• Stravitz , R. T. , Kramer , A. H. , Davern , T. , Shaikh , A. O. , Caldwell , S. H. , Mehta , R. L. , Blei , A. T. , Fontana , R. J. , McGuire , B. M. , Rossaro , L. , Smith , A. D. and Lee , W. M. 2007 . Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group . Crit Care Med , 35 : 2498 – 508 .
   PubMed Web of Science ®Google Scholar
• Suzuki , A. , Zheng , Y. W. , Kaneko , S. , Onodera , M. , Fukao , K. , Nakauchi , H. and Taniguchi , H. 2002 . Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver . J Cell Biol , 156 : 173 – 84 .
   PubMed Web of Science ®Google Scholar
• Tanaka , K. , Soto-Gutierrez , A. , Navarro-Alvarez , N. , Rivas-Carrillo , J. D. , Jun , H. S. and Kobayashi , N. 2006 . Functional hepatocyte culture and its application to cell therapies . Cell Transplant , 15 : 855 – 64 .
   PubMed Web of Science ®Google Scholar
• Teratani , T. , Yamamoto , H. , Aoyagi , K. , Sasaki , H. , Asari , A. , Quinn , G. , Sasaki , H. , Terada , M. and Ochiya , T. 2005 . Direct hepatic fate specification from mouse embryonic stem cells . Hepatology , 41 : 836 – 46 .
   PubMed Web of Science ®Google Scholar
• Tilles , A. W. , Berthiaume , F. , Yarmush , M. L. , Tompkins , R. G. and Toner , M. 2002 . Bioengineering of liver assist devices . J Hepatobiliary Pancreat Surg , 9 : 686 – 96 .
   PubMedGoogle Scholar
• Uehara , Y. , Minowa , O. , Mori , C. , Shiota , K. , Kuno , J. , Noda , T. and Kitamura , N. 1995 . Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor . Nature , 373 : 702 – 5 .
   PubMed Web of Science ®Google Scholar
• Wells , J. M. and Melton , D. A. 1999 . Vertebrate endoderm development . Annu Rev Cell Dev Biol , 15 : 393 – 410 .
   PubMed Web of Science ®Google Scholar
• Wernig , M. , Meissner , A. , Foreman , R. , Brambrink , T. , Ku , M. , Hochedlinger , K. , Bernstein , B. E. and Jaenisch , R. 2007 . In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state . Nature , 448 : 318 – 24 .
   PubMed Web of Science ®Google Scholar
• Wieder , K. J. , King , K. R. , Thompson , D. M. , Zia , C. , Yarmush , M. L. and Jayaraman , A. 2005 . Optimization of reporter cells for expression profiling in a microfluidic device . Biomed Microdevices , 7 : 213 – 22 .
   PubMedGoogle Scholar
• Wobus , A. M. and Boheler , K. R. 2005 . Embryonic stem cells: prospects for developmental biology and cell therapy . Physiol Rev , 85 : 635 – 78 .
   PubMed Web of Science ®Google Scholar
• Yamada , T. , Yoshikawa , M. , Kanda , S. , Kato , Y. , Nakajima , Y. , Ishizaka , S. and Tsunoda , Y. 2002 . In vitro differentiation of embryonic stem cells into hepatocyte-like cells identified by cellular uptake of indocyanine green . Stem Cells , 20 : 146 – 54 .
   PubMed Web of Science ®Google Scholar
• Yamamoto , H. , Quinn , G. , Asari , A. , Yamanokuchi , H. , Teratani , T. , Terada , M. and Ochiya , T. 2003 . Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application . Hepatology , 37 : 983 – 93 .
   PubMed Web of Science ®Google Scholar
• Yasunaga , M. , Tada , S. , Torikai-Nishikawa , S. , Nakano , Y. , Okada , M. , Jakt , L. M. , Nishikawa , S. , Chiba , T. , Era , T. and Nishikawa , S. 2005 . Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells . Nat Biotechnol , 23 : 1542 – 50 .
   PubMed Web of Science ®Google Scholar
• Yoshinari , K. , Sato , T. , Okino , N. , Sugatani , J. and Miwa , M. 2004 . Expression and induction of cytochromes p450 in rat white adipose tissue . J Pharmacol Exp Ther , 311 : 147 – 54 .
   PubMed Web of Science ®Google Scholar
• Zhang , Q. Y. , Dunbar , D. and Kaminsky , L. S. 2003 . Characterization of mouse small intestinal cytochrome P450 expression . Drug Metab Dispos , 31 : 1346 – 51 .
   PubMed Web of Science ®Google Scholar