The antibody paradigm: present and future development as a scaffold for biopharmaceutical drugs

References

• Aalberse , R.C and Schuurman , J. 2002 . IgG4 breaking the rules . Immunology , 105 : 9 – 19 .
   PubMed Web of Science ®Google Scholar
• Aase , A. and Michaelsen , T.E. 1994 . Opsonophagocytic activity induced by chimeric antibodies of the four human IgG subclasses with or without help from complement . Scandanavian Journal of Immunology , 39 : 581
   PubMedGoogle Scholar
• Alavi , A. and Axford , J.S. 2006 . The pivotal nature of sugars in normal physiology and disease . Wiener Medizinische Wochenschrift , 156 : 19 – 33 .
   PubMedGoogle Scholar
• Alavi , A and Axford , J.S. 2008 . Glyco-biomarkers: potential determinants of cellular physiology and pathology . Disease Markers , 25 : 193 – 205 .
   PubMedGoogle Scholar
• Andersen , D.C. and Reilly , D.E. 2004 . Production technologies for monoclonal antibodies and their fragments . Current Opinion in Biotechnology , 15 : 456 – 62 .
   PubMed Web of Science ®Google Scholar
• Anolik , J.H. , Campbell , D. Felgar , R.E. 2003 . The relationship of Fc?RIIIa genotype to degree of B cell depletion by Rituximab in the treatment of systemic lupus erythematosus . Arthritis and Rheumatism , 48 : 455 – 59 .
   PubMed Web of Science ®Google Scholar
• Anthony , R.M. , Wermeling , F. Karlsson , M.C. 2008 . Identification of a receptor required for the anti-inflammatory activity of IVIG . Proceedings of the National Academy of Science USA , 105 : 19571 – 8 .
   PubMed Web of Science ®Google Scholar
• Armour , K.L. , Atherton , A. Williamson , L.M. 2002 . The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors . Biochemical Society Transactions , 30 : 495 – 500 .
   PubMedGoogle Scholar
• Arnold , J.N. , Wormald , M.R. Suter , D.M. 2005a . Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin . Journal of Biological Chemistry , 280 : 29080 – 87 .
   PubMed Web of Science ®Google Scholar
• Arnold , J.N. , Dwek , R.A. Rudd , P.M. 2005b . Mannan binding lectin and its interaction with immunoglobulins in health and in disease . Immunology Letters , 106 : 103 – 10 .
   Google Scholar
• Atalay , R. , Zimmermann , A. Wagner , M. 2002 . Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs . Journal of Virology , 76 : 8596 – 08 .
   PubMedGoogle Scholar
• Bajtay , Z. , Csomor , E. Sandor , N. 2006 . Expression and role of Fc- and complement-receptors on human dendritic cells . Immunology Letters , 104 : 46 – 52 .
   PubMed Web of Science ®Google Scholar
• Bitonti , A.J. and Dumont , J.A. 2006 . Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway . Advances in Drug Delivery Reviews , 58 : 1106 – 18 .
   PubMed Web of Science ®Google Scholar
• Boyd , P.N. , Lines , A.C. and Patel , A.K. 1995 . The effect of the removal of sialic acid, galactose and total carbohydrate on the functional activity of Campath-1H . Molecular Immunology , 32 : 1311?1318
   Google Scholar
• Brambell , F.W.R. , Hemmings , W.A. and Morris , I.G. 1964 . A theoretical model of gammaglobulin catabolism . Nature , 203 : 1352 – 1355 .
   PubMed Web of Science ®Google Scholar
• Brekke , O.H. , Michaelsen , T.E. and Sandlie , I. 1995 . The structural requirements for complement activation by IgG: does it hinge on the hinge? . Immunology Today , 16 : 85 – 90 .
   PubMedGoogle Scholar
• Burton , DR. 1985 . Immunoglobulin G - functional sites . Molecular Immunology , 22 : 161 – 206 .
   PubMed Web of Science ®Google Scholar
• Burton , D.R. and Woof , J.M. 1992 . Human antibody effector function . Advances in Immunology , 51 : 1 – 84 .
   PubMed Web of Science ®Google Scholar
• Cambi , A. and Figdor , C.G. 2003 . Levels of complexity in pathogen recognition by C-type lectins Curent . Opinion in Cell Biology , 15 : 539 – 46 .
   PubMed Web of Science ®Google Scholar
• Campbell , M.P. , Royle , L. Radcliffe , C.M. 2008 . Glycobase and autoGU: Tools for HPLC based glycan analysis . Bioinformatics , 24 : 1214 – 6 .
   PubMed Web of Science ®Google Scholar
• Carrasco , B. , Garcia de la Torre , J. Davis , K.G. 2001 . Crystallohydrodynamics for solving the hydration problem for multi-domain proteins: open physiological conformations for human IgG . Biophysical Chemistry , 93 : 181 – 96 .
   PubMedGoogle Scholar
• Carroll , M.C. 2004 . The complement system in regulation of adaptive immunity . Nature Immunology , 5 : 981 – 6 .
   PubMed Web of Science ®Google Scholar
• Carter , P. , Presta , L. Gorman , C.M. 1992 . Humanization of an anti-p185HER2 antibody for human cancer therapy . Proceedings of the National Academy of Science USA , 89 : 4285 – 89 .
   PubMed Web of Science ®Google Scholar
• Carter , P.J. 2006 . Potent antibody therapeutics by design . Nature Reviews: Immunology , 6 : 343 – 357 .
   PubMed Web of Science ®Google Scholar
• Cartron , G. , Dacheux , L. Salles , G. 2002 . Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor Fc?RIIIa gene . Blood , 99 : 754 – 758 .
   PubMed Web of Science ®Google Scholar
• Chung , C.H. , Mirakhur , B. Chan , E. 2008 . Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose . New England Journal of Medicine , 58 : 1109 – 17 .
   Google Scholar
• Corper , A.L. , Sohi , M.K. Bonagura , V.R. 1997 . Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction . Nature Structural Biology , 4 : 374 – 81 .
   PubMedGoogle Scholar
• Cox , K.M. , Sterling , J.D. Regan , J.T. 2006 . Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor . Nature Biotechnology , 24 : 1591 – 97 .
   PubMed Web of Science ®Google Scholar
• Coxon , P.Y. , Rane , M.J. Powell , D.W. 2000 . Differential mitogen-activated protein kinase stimulation by Fc gamma receptor IIa and Fc gamma receptor IIIb determines the activation phenotype of human neutrophils . Journal of Immunology , 164 : 6530 – 37 .
   PubMedGoogle Scholar
• Cremata , J.A , Sorell , L. and Montesino , R. 2003 . Hypogalactosylation of serum IgG in patients with coeliac disease . Clinical and Experimental Immunology , 133 : 422 – 29 .
   PubMedGoogle Scholar
• Crispin , M. , Stuart , D.I. and Jones , E.Y. 2007 . Building meaningful models of glycoproteins . Nature Structural & Molecular Biology , 14 : 354
   PubMedGoogle Scholar
• Dasgupta , S. , Navarrete , A. M. Bayry , J. 2007 . A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes . Proceedings of the National Academy of Sciences USA , 104 : 8965 – 70 .
   PubMed Web of Science ®Google Scholar
• Davies , J. , Jiang , L. Labarre , M.J. 2001 . Expression of GTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies of altered glycoforms leads to an increase in ADCC thro' higher affinity for FcRIII . Biotechnology and Bioengineering , 74 : 288 – 94 .
   PubMed Web of Science ®Google Scholar
• Deisenhoffer , J. 1981 . Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-Å resolution . Biochemistry , 20 : 2361 – 70 .
   PubMedGoogle Scholar
• Derrick , J.P. and Wigley , D.B. 1994 . The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab . Journal of Molecular Biology , 243 : 906 – 18 .
   PubMed Web of Science ®Google Scholar
• Dong , X. , Storkus , W.J. and Salter , R.D. 1999 . Binding and uptake of agalactosyl IgG by mannose receptor on macrophages and dendritic cells . Journal of Immunology , 163 : 5427 – 34 .
   PubMed Web of Science ®Google Scholar
• Drescher , B. , Witte , T. and Schmitt , R.E. 2003 . Glycosylation of Fc?RIII in N163 as mechanism of regulating receptor affinity . Immunology , 110 : 335 – 40 .
   PubMedGoogle Scholar
• Dubel , S. 2007 . Recombinant therapeutic antibodies . Applied Microbiology and Biotechnology , 74 : 723 – 9 .
   PubMed Web of Science ®Google Scholar
• Duncan , A.R. and Winter , G. 1988 . The binding site for C1q on IgG . Nature , 332 : 738 – 40 .
   PubMed Web of Science ®Google Scholar
• Duquerroy , S. , Stura , E.A. Bressanelli , S. 2007 . Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation . Journal of Molecular Biology , 368 : 1321 – 31 .
   PubMed Web of Science ®Google Scholar
• Desjarlais , J.R. , Lazar , G. Zhukovsky , E.A. 2007 . Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective . Drug Discovery Today , 12 : 898 – 910 .
   PubMed Web of Science ®Google Scholar
• Edberg , J.C. and Kimberly , R.P. 1997 . Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding . Journal of Immunology , 158 : 3849 – 57 .
   Google Scholar
• Edwards , S.W. , Watson , F. and Gasmi , L. 1997 . Activation of human neutrophils by soluble immune complexes: role of Fc gamma RII and Fc gamma RIIIb in stimulation of the respiratory burst and elevation of intracellular Ca2+ . Annals of the New York Academy of Sciences , 832 : 341 – 57 .
   PubMedGoogle Scholar
• Famm , K. and Winter , G. 2006 . Engineering aggregation-resistant proteins by directed evolution . Protein Engineering Design and Selection , 19 : 479 – 81 .
   PubMedGoogle Scholar
• Farooq , M. , Takahashi , N. Arrol , H. 1997 . Glycosylation of polyclonal and paraprotein IgG in multiple myeloma . Glycoconjugate Journal , 14 : 489 – 92 .
   PubMedGoogle Scholar
• Ferrara , C. , Brunker , P. Moser , S. 2006a . Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II . Biotechnology Bioengineering , 93 : 851 – 61 .
   PubMed Web of Science ®Google Scholar
• Ferrara , C. , Stuart , F. Sondermann , P. 2006b . The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to nonfucosylated IgG glycoforms . Journal of Biological Chemistry , 281 : 5032 – 36 .
   PubMed Web of Science ®Google Scholar
• Fitchette , A.C. , Dinh , O.T. Faye , L. 2007 . Plant proteomics and glycosylation . Methods in Molecular Biology , 355 : 317 – 42 .
   PubMedGoogle Scholar
• Gardy , J.L. , Lynn , D.J. Brinkman , F.S. 2009 . Hancock RE. Enabling a systems biology approach to immunology: focus on innate immunity . Trends in Immunology , May 8. (Epub ahead of print)
   PubMedGoogle Scholar
• Garred , P. , Madsen , H.O. Marquart , H. 2000 . Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study . Journal of Rheumatology , 2 ( 7 ) : 26 – 34 .
   Google Scholar
• Gazi , U. and Martinez-Pomares , L. 2009 . Influence of the mannose receptor in host immune responses . Immunobiology , Jan 20. (Epub ahead of print)
   PubMedGoogle Scholar
• Georgiou , G. and Segatori , L. 2005 . Preparative expression of secreted proteins in bacteria: status report and future prospects . Current Opinion in Biotechnology , 16 : 538 – 45 .
   PubMed Web of Science ®Google Scholar
• Ghetie , V. and Ward , E.S. 2002 . Transcytosis and catabolism of antibody . Immunology Research , 25 : 97 – 113 .
   PubMed Web of Science ®Google Scholar
• Girardi , E. , Holdom , M.D. Davies , A. M. 2009 . The crystal structure of rabbit IgG-Fc . Biochemical Journal , 417 : 77 – 83 .
   PubMedGoogle Scholar
• Go , M.F. , Schrohenloher , R.E. and Tomana , M. 1994 . Deficient galactosylation of serum IgG in inflammatory bowel disease: correlation with disease activity . Journal of Clinical Gastroenterology , 18 : 86 – 87 .
   PubMed Web of Science ®Google Scholar
• Graille , M. , Stura , E.A. Corper , A.L. 2000 . Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity . Proceedings of the National Academy of Science USA , 97 : 5399 – 404 .
   PubMed Web of Science ®Google Scholar
• Groenink , J. , Spijker , J. van den Herik-Oudijk , I.E. 1996 . On the interaction between agalactosyl IgG and Fc gamma receptors . European Journal of Immunology , 26 : 1404 – 7 .
   PubMed Web of Science ®Google Scholar
• Guddat , L.W. , Herron , J.N. and Edmundson , A.B. 1993 . Three-dimensional structure of a human immunoglobulin with a hinge deletion . Proceedings of the National Academy of Science USA , 90 : 4271 – 75 .
   PubMed Web of Science ®Google Scholar
• Hamilton , S.R. , Davidson , R.C. Sethuramann , N. 2006 . Humanization of yeast to produce complex terminally sialylated glycoproteins . Science , 313 : 1441 – 3 .
   PubMed Web of Science ®Google Scholar
• Harris , L.J. 1997 . Refined structure of an intact IgG2a monoclonal antibody . Biochemistry , 36 : 1581 – 97 .
   PubMed Web of Science ®Google Scholar
• Hill , D.R. , Aumiller , J.J. Shi , X. 2006 . Isolation and analysis of a baculovirus vector that supports recombinant glycoprotein sialylation by SfSWT-1 cells cultured in serum-free medium . Biotechnology and Bioengineering , 95 : 37 – 47 .
   PubMed Web of Science ®Google Scholar
• Hinton , P.R. , Xiong , J.M. Johlfs , M.G. 2006 . An engineered human IgG1 antibody with longer serum half-life . Journal of Immunology , 176 : 346 – 56 .
   PubMed Web of Science ®Google Scholar
• Holgate , R.G. and Baker , M.P. 2009 . Circumventing immunogenicity in the development of therapeutic antibodies . IDrugs , 12 : 233 – 7 .
   PubMed Web of Science ®Google Scholar
• Holland , M. , Takada , K. Okumoto , T. 2002 . Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis . Clinical and Experimental Immunology , 29 : 183 – 190 .
   Google Scholar
• Holland , M. , Yagi , H. Takahashi , N. 2006 . Differential glycosylation of polyclonal IgG, IgG-Fc and IgG-Fab isolated from the sera of patients with ANCA associated systemic vasculitis . Biochimica et Biophysica Acta , 1760 : 669 – 77 .
   PubMed Web of Science ®Google Scholar
• Huang , L. , Biolsi , S. Bales , K.R. 2006 . Impact of variable domain glycosylation on antibody clearance: An LC/MS characterization . Analytical Biochemistry , 349 : 197 – 207 .
   PubMed Web of Science ®Google Scholar
• Jefferis , R. , Steinitz , M. and Nik Jaffar , M.I.B. 1984 . VIII. A monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by Histidine/Arginine interchange at residue 435 of immunoglobulin G . Immunology Letters , 7 : 191 – 94 .
   PubMed Web of Science ®Google Scholar
• Jefferis , R. , Lund , J. Mizutani , H. 1990 . Comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins . Biochemical Journal , 268 : 529 – 37 .
   PubMed Web of Science ®Google Scholar
• Jefferis , R. , Lund , J. and Pound , J.D. 1998 . IgG-Fc mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation . Immunological Reviews , 163 : 59 – 76 .
   PubMed Web of Science ®Google Scholar
• Jefferis , R. 2007 . Antibody therapeutics: isotype and glycoform selection . Expert Opinion on Biological Therapeutics , 7 : 1401 – 13 .
   PubMed Web of Science ®Google Scholar
• Jefferis , R. 2009a . Glycosylation as a strategy to improve antibody-based therapeutics . Nature Reviews: Drug Discovery , 8 : 226 – 34 .
   PubMed Web of Science ®Google Scholar
• Jefferis , R. and Lefranc , M-P. 2009b . Human immunoglobulin allotypes possible implications for immunogenicity mAb In press
   Google Scholar
• Jones , A.J. , Papac , D.I. Chin , E.H. 2007 . Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys . Glycobiology , 17 : 529 – 40 .
   PubMed Web of Science ®Google Scholar
• Jostok , T. 2004 . Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries . Journal of Immunological Methods , 289 : 65 – 80 .
   PubMedGoogle Scholar
• Kabelitz , D. and Medzhitov , R. 2007 . Innate immunity-cross-talk with adaptive immunity through pattern recognition receptors and cytokines . Current Opinion in Immunology , 19 : 1 – 3 .
   PubMed Web of Science ®Google Scholar
• Kaneko , Y. , Nimmerjahn , F. and Ravetch , J. 2006 . Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation . Science , 313 : 670 – 3 .
   PubMed Web of Science ®Google Scholar
• Kaprivova , A. , Stemmer , C. Altmann , F. 2004 . Targeted knockouts of Physcomitrella lacking plant-specific immunogenic N-glycans . Plant Biotechnology Journal , 2 : 517 – 23 .
   PubMed Web of Science ®Google Scholar
• Keskin , O. 2007 . Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies . BMC Structural Biology , 7 : 31
   PubMedGoogle Scholar
• Koene , H.R. , Kleijer , M. Algra , J. 1997 . Fc?RIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc?RIIIa, independently of the Fc? RIIIa-48L/R/H phenotype . Blood , 90 : 1109 – 14 .
   PubMed Web of Science ®Google Scholar
• Keck , R. , Nayak , N. Lerner , L. 2008 . Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content . Biologicals , 36 : 49 – 60 .
   PubMed Web of Science ®Google Scholar
• Kibe , T. , Fujimoto , S. and Ishida , C. 1996 . Glycosylation and placental transport of immunoglobulin G . Journal of Clinical Biochemistry and Nutrition , 21 : 57 – 63 .
   Google Scholar
• Kohler , G. and Milstein , C. 1975 . Continuous cultures of fused cells secreting antibody of predefined specificity . Nature , 256 : 495 – 97 .
   PubMed Web of Science ®Google Scholar
• Koki Makabe , K. , Nakanishi1 , T. Tsumoto , K. 2008 . Thermodynamic consequences of Mutations in Vernier Zone Residues of a Humanized Anti-human Epidermal Growth Factor Receptor Murine Antibody, 528 . Journal of Biological Chemistry , 283 : 1156 – 66 .
   PubMedGoogle Scholar
• Krapp , S. , Mimura , Y. Jefferis , R. 2003 . Structural analysis of human IgG glycoforms reveals a correlation between oligosaccharide content, structural integrity and Fc?-receptor affinity . Journal of Molecular Biology , 325 : 979 – 89 .
   PubMed Web of Science ®Google Scholar
• Kumpel , B.M. , Wang , Y. Griffiths , H.L. 1995 . The biological activity of human monoclonal IgG anti-D is reduced by beta-galactosidase treatment . Human Antibodies and Hybridomas , 6 : 82 – 8 .
   PubMedGoogle Scholar
• Kumpel , B.M. 2007 . Efficacy of RhD monoclonal antibodies in clinical trials as replacement therapy for prophylactic anti-D immunoglobulin: more questions than answers . Vox Sang , 93 : 99 – 111 .
   PubMed Web of Science ®Google Scholar
• Langdon , R.H. , Cuccui , J. and Wren , B.W. 2009 . N-linked glycosylation in bacteria: an unexpected application . Future Microbiology , 4 : 401 – 12 .
   PubMed Web of Science ®Google Scholar
• LiÉnard , D. , Sourrouille , C. Gomord , V. 2007 . Pharming and transgenic plants . Biotechnology Annual Reviews , 13 : 115 – 47 .
   PubMedGoogle Scholar
• Lifely , M.R. , Hale , G. and Boyse , S. 1995 . Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions . Glycobiology , 5 : 813 – 22 .
   PubMed Web of Science ®Google Scholar
• Lim , A. , Reed-Bogan , A. and Harmon , B.J. 2008 . Glycosylation profiling of a therapeutic recombinant monoclonal antibody with two N-linked glycosylation sites using liquid chromatography coupled to a hybrid quadrupole time-of-flight mass spectrometer . Analytical Biochemistry , 375 : 163 – 72 .
   PubMed Web of Science ®Google Scholar
• Lin , T.S. , Flinn , I.W. Modali , R. 2005 . FCGR3A and FCGR2A polymorphisms may not correlate with response to Alemtuzumab in chronic lymphocytic leukemia . Blood , 105 : 289 – 91 .
   PubMed Web of Science ®Google Scholar
• Lonberg , N. 2008 . Fully human antibodies from transgenic mouse and phage display platforms . Current Opinion in Immunology , 20 : 450 – 9 .
   PubMed Web of Science ®Google Scholar
• Lu , Y. , Harding , S.E. Michaelsen , T.E. 2007 . Solution conformation of wild-type and mutant IgG3 and IgG4 immunoglobulins using crystallo-hydrodynamics: possible implications for complement activation . Biophysical Journal , 93 : 3733 – 44 .
   PubMed Web of Science ®Google Scholar
• Lucisano Valim , Y.M. and Lachmann , P.J. 1991 . The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions . Clinical and Experimental Immunology , 84 : 1 – 8 .
   PubMed Web of Science ®Google Scholar
• Lubinski , J. , Nagashunumugan , T. and Friedman , H.M. 1998 . Viral interference with antibody and complement . Seminars in Cellular Development and Biology , 9 : 329 – 337 .
   PubMedGoogle Scholar
• Lund , J. , Winter , G. Jones , P.T. 1991 . Human Fc?RI and Fc?RII interact with distinct but overlapping sites on human IgG . Journal of Immunology , 147 : 2657 – 62 .
   PubMed Web of Science ®Google Scholar
• Lund , J. , Tanaka , T. Takahashi , N. 1990 . A protein structural change in aglycosylated IgG3 correlates with loss of huFc gamma R1 and huFc gamma R111 binding and/or activation . Molecular Immunology , 27 : 1145 – 53 .
   PubMed Web of Science ®Google Scholar
• Lund , J. , Takahashi , N. Pound , J. 1996 . Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc?RI and influence the synthesis of its oligosaccharide chains . Journal of Immunology , 157 : 4963 – 69 .
   PubMed Web of Science ®Google Scholar
• Louis , E.L. , Ghoul , Z. Vermeire , S. 2004 . Association between polymorphism in IgG Fc?IIIa coding gene and biological response to Infliximab in Crohn's disease . Alimentary Pharmacology and Therapeutics , 19 : 511 – 19 .
   PubMed Web of Science ®Google Scholar
• Macor , P. and Tedesco , F. 2007 . Complement as effector system in cancer immunotherapy . Immunology Letters , 111 : 6 – 13 .
   PubMed Web of Science ®Google Scholar
• Maenaka , K. , van der Merwe , P.A. Stuart , D.I. 2001 . The human low affinity Fcgamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties . Journal of Biological Chemistry , 276 : 44898 – 904 .
   PubMedGoogle Scholar
• Magdelaine-Beuzelin , C. , Goodall , M. Jefferis , R. 2009 . IgG1 heavy chain-coding gene polymorphism, marker of G1m allotypes, and development of antibodies-to-Infliximab . Pharmacogenetics and Genomics , 19 : 383 – 7 .
   PubMed Web of Science ®Google Scholar
• Malhotra , R. , Wormald , M.R. Rudd , P.M. 1995 . Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannosebinding protein . Nature Medicine , 1 : 237 – 43 .
   PubMed Web of Science ®Google Scholar
• Makabe , K. 2008 . Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528 . Journal of Biological Chemistry , 283 : 1156 – 66 .
   PubMed Web of Science ®Google Scholar
• Marquart , M. , Deisenhofer , J. Huber , R. 1980 . Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.0 Å resolution . Journal of Molecular Biology , 141 : 369 – 91 .
   PubMed Web of Science ®Google Scholar
• Masuda , K. , Yamaguchi , Y. Kato , K. 2000 . Pairing of oligosaccharides in the Fc region of immunoglobulin G . FEBS Letters , 473 : 349 – 57 .
   PubMed Web of Science ®Google Scholar
• Masuda , K. , Kubato , T. Kaneko , E. 2007 . Enhanced binding affinity for FcgammaRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity . Molecular Immunology , 44 : 3122 – 31 .
   PubMed Web of Science ®Google Scholar
• Matsumiya , S. , Yamaguchi , Y. Saito , J. 2007 . Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1 . Journal of Molecular Biology , 368 : 767 – 79 .
   PubMed Web of Science ®Google Scholar
• Michaelsen , TE , Brekke , OH Aase , A. 1994 . One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge . Proceedings of the National Academy of Science USA , 91 : 9243 – 47 .
   PubMedGoogle Scholar
• Michaelsen , T.E. , Garred , P. and Aase , A. 1991 . Human IgG subclass pattern of inducing complement-mediated cytolysis depends on antigen concentration and to a lesser extent on epitope patchiness, antibody affinity and complement concentration . European Journal of Immunology , 21 : 11 – 6 .
   PubMed Web of Science ®Google Scholar
• Miescher , S. , Spycher , M.O. Amstutz , H. 2004 . A single recombinant anti-RhD IgG prevents RhD immunization: association of RhD-positive red blood cell clearance rate with polymorphisms in the Fc?RIIA and Fc?IIIA genes . Blood , 103 : 4028 – 35 .
   PubMed Web of Science ®Google Scholar
• Mimura , Y. , Ashton , P.R. Takahashi , N. 2007 . Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry . Journal of Immunological Methods , 326 : 116 – 26 .
   PubMed Web of Science ®Google Scholar
• Mimura , Y. , Church , S. Ghirlando , R. 2000 . The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms . Molecular Immunology , 37 : 697 – 706 .
   PubMed Web of Science ®Google Scholar
• Mimura , Y. , Ashton , P.R. Takahashi , N. 2007 . Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry . J Immunol Methods , 326 : 116 – 26 .
   PubMed Web of Science ®Google Scholar
• Mimura , Y. , Sondermann , P. Ghirlando , R. 2001 . The role of oligosaccharide residues of IgG1-Fc in Fc?IIb binding . Journal of Biological Chemistry , 276 : 45539 – 47 .
   PubMed Web of Science ®Google Scholar
• Morgan , A. , Jones , N.D. Nesbitt , A.M. 1995 . The N-terminal end of the CH2 domain of chimeric human IgG1 anti-HLA-DR is necessary for C1q, Fc?RI and Fc?RII binding . Immunology , 86 : 319 – 24 .
   PubMed Web of Science ®Google Scholar
• Moutel , S. and Perez , F. 2008 . Antibodies-Europe. Engineering the next generation of antibodies . Biotechnology Journal , 3 : 298 – 300 .
   PubMedGoogle Scholar
• Namboodiri , A.M. , Budkowska , A. Niertert , P.J. 2007 . Fc gamma receptor-like hepatitis C virus core protein binds differentially to IgG of discordant Fc (GM) genotypes . Molecular Immunology , 44 : 3805 – 08 .
   PubMedGoogle Scholar
• Natsume , A. , Wakitani , M. Yamane-Ohnuki , N. 2005 . Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded antibody comprising a single-chain antibody linked the antibody constant region . Journal of Immunological Methods , 306 : 93 – 103 .
   PubMedGoogle Scholar
• Natsume , A. , Wakitani , M. Yamane-Ohnuki , N. 2006 . Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded bispecific antibody comprising of two single-chain antibodies linked to the antibody constant region . Journal of Biochemistry , 140 : 359 – 368 .
   PubMed Web of Science ®Google Scholar
• Natsume , A. , In , M. Takamura , H. 2008 . Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities . Cancer Research , 68 : 3863 – 72 .
   PubMed Web of Science ®Google Scholar
• Nezlin , R. and Ghetie , V. 2004 . Interactions of immunoglobulins outside the antigencombining site . Advances in Immunology , 82 : 155 – 215 .
   PubMed Web of Science ®Google Scholar
• Nimmerjahn , F. and Ravetch , J. 2007 . Fc-receptors as regulators of immunity . Advances in Immunology , 96 : 179 – 204 .
   PubMed Web of Science ®Google Scholar
• Nimmerjahn , F. and Ravetch , J. 2008 . Fcgamma receptors as regulators of immune responses . Nature Reviews in Immunology , 8 : 34 – 47 .
   PubMed Web of Science ®Google Scholar
• Nitsche-Schmitz , D.P. , Johansson , H.M. Sastalla , I. 2007 . Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q . Journal of Biological Chemistry , 282 : 17530 – 36 .
   PubMed Web of Science ®Google Scholar
• Niwa , R. , Natsume , A. Uehara , A. 2005 . IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides . Journal of Immunological Methods , 306 : 151 – 60 .
   PubMed Web of Science ®Google Scholar
• Novak , J. , Tomana , M. Shah , G.R. 2005 . Heterogeneity of IgG glycosylation in adult periodontal disease . Journal of Dental Research , 84 : 897 – 901 .
   PubMed Web of Science ®Google Scholar
• Okazaki , A. , Shoji-Hosaka , E. and Nakamura , K. 2004 . Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIa . Journal of Molecular Biology , 336 : 1239 – 49 .
   PubMed Web of Science ®Google Scholar
• Olsen , JK. , Santos , R.A. and Grose , C. 1998 . Varicella-zoster virus glycoprotein gE: endocytosis and trafficking of the Fc receptor . Journal of Infectious Disease , 178 ( 1 ) : S2 – 6 .
   Google Scholar
• Padlan , E. A. 1990 . “ Fc receptors and the action of antibodies ” . Edited by: Metzger H , H. 12 – 30 . Washington D.C : American Society for Microbiology .
   Google Scholar
• Padlan , E.A. 1996 . X-ray crystallography of antibodies . Advances in Protein Chemistry , 49 : 57 – 133 .
   PubMedGoogle Scholar
• Parekh , R.B. , Dwek , R.A. and Sutton , B.J. 1985 . Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG . Nature , 316 : 452 – 57 .
   PubMed Web of Science ®Google Scholar
• Pascoe , D.E. , Arnott , D. Papoutsakis , E.T. 2007 . Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles . Biotechnology and Bioengineering , 98 : 391 – 410 .
   PubMedGoogle Scholar
• Peipp , M. , Lammerts van Bueren , J.J. and Schneider-Merck , T. 2008 . Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells . Blood , 112 : 2390 – 9 .
   PubMed Web of Science ®Google Scholar
• Podack , E.R. , Deyev , V. and Shiratsuchi , M. 2007 . Pore formers of the immune system . Advances in Experimental Medicine and Biology , 598 : 325 – 41 .
   PubMed Web of Science ®Google Scholar
• Potgieter , T.I. , Cukan , M. and Drummond , J.E. 2009 . Production of monoclonal antibodies by glycoengineered Pichia pastoris . Journal of Biotechnology , 139 : 318 – 25 .
   PubMed Web of Science ®Google Scholar
• Presta , L. 2008 . Molecular engineering and design of therapeutic antibodies . Current Opinion in Immunology , 20 : 460 – 70 .
   PubMed Web of Science ®Google Scholar
• Pritsch , O. , Hudry-Clergeon , H. Buckle , H. 1996 . Can Immunoglobulin CH1 Constant Region Domain Modulate Antigen Binding Affinity of Antibodies? . Journal of Clinical Investigation , 98 : 2235 – 43 .
   PubMedGoogle Scholar
• Qian , J. , Liu , T. Yang , L. 2007 . Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion . Analytical Biochemistry , 364 : 8 – 18 .
   PubMed Web of Science ®Google Scholar
• Radaev , S. , Motyka , S. Fridman , W.H. 2001 . The structure of human type Fc?III receptor in complex with Fc . Journal of Biological Chemistry , 276 : 16469 – 77 .
   PubMed Web of Science ®Google Scholar
• Radaev , S. and Sun , P. 2002 . Recognition of immunoglobulins by Fc gamma receptors . Molecular Immunology , 38 : 1073 – 83 .
   PubMed Web of Science ®Google Scholar
• Radaev , S. and Sun , P.D. 2001 . Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors . Journal of Biological Chemistry , 276 : 16478 – 83 .
   PubMed Web of Science ®Google Scholar
• Radstake , T.R. , Svenson , M. and Eijsbouts , A.M. 2008 . Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis . Annals of Rheumatic Diseases , 2008 Nov 19. (Epub ahead of print)
   Google Scholar
• Raju , T.S. and Scallon , B. 2007 . Fc glycans terminated with N-acetylglucosamine residues increase antibody resistance to papain . Biotechnology Progress , 23 : 964 – 71 .
   PubMed Web of Science ®Google Scholar
• Raju , T.S. and Scallon , B. 2006 . Glycosylation in the Fc domain of IgG increases resistance to proteolytic cleavage by papain . Biochemical Biophysical Research Communications , 341 : 797 – 803 .
   PubMed Web of Science ®Google Scholar
• Redpath , S. , Michaelsen , T.E. Sandlie , I. 1998 . The influence of the hinge region length in binding of human IgG to human Fcgamma receptors . Human Immunology , 59 : 720 – 7 .
   PubMed Web of Science ®Google Scholar
• Reichert , J.M. and Valge-Archer , V.E. 2007 . Development trends for monoclonal antibody cancer therapeutics . Nature Reviews: Drug Discovery , 6 : 349 – 56 .
   PubMed Web of Science ®Google Scholar
• Rhodes , D.A. and Trowsdale , J. 2007 . TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain . Molecular Immunology , 44 : 2406 – 14 .
   PubMed Web of Science ®Google Scholar
• Rodriguez , M.E. , van der Pol , W-L. and Sanders , L.A.M. 1999 . Crucial role of Fc RIIa (CD32) in assessment of functional anti-Streptococcus pneumoniae antibody activity in human sera . Journal of Infectious Diseases , 179 : 423 – 33 .
   PubMed Web of Science ®Google Scholar
• Roopenian , D.C. and Akilesh , S. 2007 . FcRn: the neonatal Fc receptor comes of age . Nature Reviews: Immunology , 7 : 715 – 25 .
   PubMed Web of Science ®Google Scholar
• Roux , K.H. , Strelets , L. and Michaelsen , T.E. 1997 . Flexibility of human IgG . subclasses. Journal of Immunology , 159 : 3372 – 82 .
   PubMed Web of Science ®Google Scholar
• Routier , F.H. , Hounsell , E.F. Rudd , P.M. 1998 . Quantitation of human IgG glycoforms isolated from rheumatoid sera: a critical evaluation of chromatographic methods . Journal of Immunological Methods , 213 : 113 – 30 .
   PubMed Web of Science ®Google Scholar
• Rudd , P.M. and Dwek , R.A. 1997 . Glycosylation: heterogeneity and the 3D structure of proteins . Critical Reviews in Biochemistry and Molecular Biology , 32 : 1 – 100 .
   PubMed Web of Science ®Google Scholar
• Saevarsdottir , S. , Vikingsdottir , T. and Valdimarsson , H. 2004 . The potential role of mannan-binding lectin in the clearance of self-components including immune complexes . Scandanavian Journal of Immunology , 60 : 23 – 9 .
   PubMed Web of Science ®Google Scholar
• Sanguineti , S. , Centeno Crowley , J.M. 2007 . Specific recognition of a DNA immunogen by its elicited antibody . Journal of Molecular Biology , 370 : 183 – 95 .
   PubMedGoogle Scholar
• Sagawa , T. , Oda , M. Morii , H. 2005 . Conformational changes in the antibody constant domains upon hapten-binding . Molecular Immunology , 42 : 9 – 18 .
   PubMed Web of Science ®Google Scholar
• Saphire , E.O. , Stanfield , R.L. Crispin , M.D. 2002 . Contrasting IgG structures reveal extreme asymmetry and flexibility . Journal of Molecular Biology , 319 : 9 – 18 .
   PubMedGoogle Scholar
• Satoh , M. , Iida , S. and Shitara , K. 2006 . Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies . Expert Opinion on Biological Therapy , 6 : 1161 – 73 .
   PubMed Web of Science ®Google Scholar
• Sauer-Eriksson , A.E. , Kleywegt , G.J. Uhl , M. 1995 . Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG . Structure , 3 : 265 – 278 .
   PubMed Web of Science ®Google Scholar
• Scallon , B. , Tam , S.H. McCarthy , S.G. 2007 . Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality . Molecular Immunology , 44 : 1524 – 34 .
   PubMed Web of Science ®Google Scholar
• Shibata-Koyama , M. , Iida , S. Misaka , H. 2009 . Nonfucosylated rituximab potentiates human neutrophil phagocytosis through its high binding for FcgammaRIIIb and MHC class II expression on the phagocytotic neutrophils . Experimental Hematology , 37 : 309 – 21 .
   PubMed Web of Science ®Google Scholar
• Shields , R.L. , Namenuk , A.K. Hong , K. 2001 . High resolution mapping of the binding site on human IgG1 for Fc?RI, Fc?RII, Fc?RIII, and FcRn and design of IgG1 variants with improved binding to the Fc?R . Journal of Biological Chemistry , 276 : 6591 – 604 .
   PubMed Web of Science ®Google Scholar
• Shields , R.L. , Lai , J. Keck , R. 2002 . Lack of Fucose on Human IgG1 N-Linked oligosaccharide improves binding to human Fc?RIII and Antibody-dependent cellular toxicity . Journal of Biological Chemistry , 277 : 26733 – 40 .
   PubMed Web of Science ®Google Scholar
• Shinkawa , T , Nakamura , K Yamane , N . 2003 . The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity . Journal of Biological Chemistry , 278 : 3466 – 73 .
   PubMed Web of Science ®Google Scholar
• Shoji-Hosaka , E. , Kobayashi , Y. Wakitani , Y. 2006 . Enhanced Fc-dependent cellular cytotoxicity of Fc fusion proteins derived from TNF receptor II and LFA-3 by fucose removal from Asn-linked oligosaccharides . Journal of Biochemistry (Tokyo) , 140 : 777 – 83 .
   PubMed Web of Science ®Google Scholar
• Siberil , S. , Dutertre , C.A. and Fridman , W.H. 2007 . The key to optimize therapeutic antibodies? . Critical Reviews in Oncology and Hematology , 62 : 26 – 33 .
   PubMed Web of Science ®Google Scholar
• Simister , N.E. and Mostov , K.E. 1989 . An Fc receptor structurally related to MHC class I antigens . Nature , 337 : 184 – 7 .
   PubMed Web of Science ®Google Scholar
• Simister , N.E. 2003 . Placental transport of immunoglobulin G . Vaccine , 21 : 3365 – 69 .
   PubMed Web of Science ®Google Scholar
• Sohi , M.K. , Corper , A.L. Wan , T. 1996 . Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4 . Immunology , 88 : 636 – 41 .
   PubMed Web of Science ®Google Scholar
• Sondermann , P. , Huber , R. Oosthuizen , V. 2000 . The 3.2-A crystal structure of the human IgG1 Fc -Fc?RIII complex . Nature , 406 : 267 – 273 .
   PubMed Web of Science ®Google Scholar
• Sondermann , P. , Kaiser , J. and Jacob , U. 2001 . Molecular basis for immune complex recognition: a comparison of Fc-receptor structures . Journal of Molecular Biology , 309 : 737 – 49 .
   PubMed Web of Science ®Google Scholar
• Sprague , E.R. , Martin , W.L. and Bjorkman , P.J. 2004 . pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI . Journal of Biological Chemistry , 279 : 14184 – 93 .
   PubMed Web of Science ®Google Scholar
• Stanfield , R.L. , Zemla , A. Wilson , I.A. 2006 . Antibody elbow angles are influenced by their light chain class . Journal of Molecular Biology , 357 : 1566 – 74 .
   PubMed Web of Science ®Google Scholar
• Suzuki , E. , Niwa , R. Saji , S. 2007 . A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients . Clinical Cancer Research , 13 : 1875 – 82 .
   PubMed Web of Science ®Google Scholar
• Taylor , M.E. and Drickamer , K. 2003 . Structure-function analysis of C-type animal lectins . Methods in Enzymology , 363 : 3 – 16 .
   PubMedGoogle Scholar
• Umana , P. , Jean-Mairet , J. Moudry , R. 1999 . Engineered glycoforms of an anti-neuroblastoma. IgG1 with optimized antibody-dependent cellular cytotoxic activity . Nature Biotechnology , 17 : 176 – 80 .
   PubMed Web of Science ®Google Scholar
• Vaccaro , C. , Zhou , J. Ober , R.J. 2005 . Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels . Nature Biotechnology , 23 : 1283 – 88 .
   PubMed Web of Science ®Google Scholar
• van der Neut Kolfschoten , M. , Schuurman , J. Losen , M. 2007 . Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange . Science , 317 : 1554 – 7 .
   PubMed Web of Science ®Google Scholar
• Van Droogenbroeck , B. , Cao , J. Stadlmann , J. 2007 . Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds . Proceedings of the National Academy of Science USA , 104 : 1430
   PubMed Web of Science ®Google Scholar
• Voice , J.K. and Lachmann , P.J. 1997 . Neutrophil Fc gamma and complement receptors involved in binding soluble IgG immune complexes and in specific granule release induced by soluble IgG immune complexes . European Journal of Immunology , 27 : 2514 – 23 .
   PubMed Web of Science ®Google Scholar
• Walker , M.R. , Lund , J. Thompson , K.M. 1989 . Aglycosylation of human IgG1 and Igg3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and/or Fc gamma RII receptors . Biochemical Journal , 259 : 347 – 53 .
   PubMed Web of Science ®Google Scholar
• Walsh , G. and Jefferis , R. 2006 . Post-translational modifications in the context of therapeutic proteins . Nature Biotechnology , 24 : 1241 – 52 .
   PubMed Web of Science ®Google Scholar
• Wang , S.Y. and Weiner , G. 2008 . Complement and cellular cytotoxicity in antibody therapy of cancer . Expert Opinion on Biological Therapy , 8 : 759 – 68 .
   PubMed Web of Science ®Google Scholar
• Warmerdam , P.A.M. , van de Winkel , J.G.J. Vlug , A. 1991 . A single amino acid in the second IgG like domain of the human Fc? receptor II is critical for human IgG2 binding . Journal of Immunology , 147 : 1338 – 43 .
   PubMed Web of Science ®Google Scholar
• Webster , A.C. , Pankhurst , T. Rinaldi , F. 2006 . Monoclonal and polyclonal antibody therapy for treating acute rejection in kidney transplant recipients: a systematic review of randomized trial data . Transplantation , 81 : 953 – 65 .
   PubMed Web of Science ®Google Scholar
• West , A..P. and Bjorkman , P.J. 2000 . Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor . Biochemistry , 39 : 9698 – 708 .
   PubMed Web of Science ®Google Scholar
• Williams , P.J. , Arkwright , P.D. and Rudd , P.M. 1995 . Short communication: Selective transport of maternal IgG to the foetus . Placenta , 16 : 749 – 56 .
   PubMedGoogle Scholar
• Woof , J.M. , Partridge , L.J. Jefferis , R. 1986 . Localisation of the monocyte binding region on immunoglobulin G . Molecular Immunology , 23 : 319 – 30 .
   PubMed Web of Science ®Google Scholar
• Woof , J.M. and Burton , D.R. 2004 . Human antibody-Fc receptor interactions illuminated by crystal structures . Nature Reviews: Immunology , 4 : 89 – 99 .
   PubMed Web of Science ®Google Scholar
• Wormald , M.R. , Rudd , P. M. Harvey , D.J. 1997 . Variations in oligosaccharideprotein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides . Biochemistry , 36 : 1370 – 80 .
   PubMed Web of Science ®Google Scholar
• Woodnutt , G. , Violand , B. and North , M. 2008 . Advances in protein therapeutics . Current Opinion in Drug Discovery and Development , 11 ( 6 ) : 754 – 61 .
   PubMedGoogle Scholar
• Wuhrer , M. , Porcelijn , L. Kapur , R. 2009 . Regulated glycosylation patterns of IgG during alloimmune responses against human platelet antigens . Journal of Proteome Research , 8 : 450 – 6 .
   PubMedGoogle Scholar
• Yamada , E. , Tsukamoto , Y. Sasaki , R. 1997 . Structural changes of immunoglobulin G oligosaccharides with age in healthy human serum . Glycoconjugate Journal , 14 : 401 – 5 .
   PubMed Web of Science ®Google Scholar
• Yamaguchi , Y. , Kato , K. Shindo , M. 1990 . Dynamics of the carbohydrate chains attached to the Fc portion of immunoglobulin G as studied by NMR spectroscopy assisted by selective 13C labeling of the glycans . Journal of Biomolecular NMR , 12 : 385 – 94 .
   Google Scholar
• Yamaguchi , Y. , Nishimura , M. Nagano , M. 2006 . Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy . Biochimica et Biophysica Acta , 1760 : 693 – 700 .
   PubMedGoogle Scholar
• Youings , A. , Chang , S.C. Dwek , R.A. 1996 . Site-specific glycosylation of human immunoglobulin G is altered in four rheumatoid arthritis patients . Biochemical Journal , 314 : 621 – 30 .
   PubMed Web of Science ®Google Scholar