Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Meng-Jung ChiangDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD20993, USA

Faik N MusayevDepartment of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, School of PharmacyVirginia Commonwealth University, Richmond, VA23298, USA

Martina KosikovaDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD20993, USA

Zhengshi LinDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD20993, USA

Yamei GaoDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD20993, USA

Philip D MosierDepartment of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, School of PharmacyVirginia Commonwealth University, Richmond, VA23298, USA

Bashayer AlthufairiDepartment of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, School of PharmacyVirginia Commonwealth University, Richmond, VA23298, USA

Zhiping YeDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD20993, USA

Qibing ZhouDepartment of Nanomedicine and Biopharmaceuticals, National Engineering Research Center for NanomedicineHuazhong University of Science and Technology, Wuhan, Hubei430074, China

Umesh R DesaiDepartment of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, School of PharmacyVirginia Commonwealth University, Richmond, VA23298, USA

Hang XieDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD20993, USACorrespondence[email protected] [email protected]

Martin K SafoDepartment of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, School of PharmacyVirginia Commonwealth University, Richmond, VA23298, USACorrespondence[email protected] [email protected]

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Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

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Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Supplementary Figure S1

Supplementary Figure S2

Supplementary Table S1

Supplementary Table S2

Supplementary Table S3

Related Research Data

Related research

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