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miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9

Jie SongInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Yajie HuInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Hongzhe LiInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Xing HuangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Huiwen ZhengInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Yunguang HuInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Jingjing WangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Xi JiangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Jiaqi LiInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Zening YangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Haitao FanInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Lei GuoInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Haijing ShiInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Zhanlong HeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Fengmei YangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Xi WangInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChina

Shaozhong DongInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChinaCorrespondence[email protected]

Qihan LiInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChinaCorrespondence[email protected]

Longding LiuInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesKunmingChina;Key Laboratory of Systemic Innovative Research on Virus VaccineChinese Academy of Medical SciencesKunmingChinaCorrespondence[email protected]

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miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9

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miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9

Supplementary Information

Supplementary Figure S1

Supplementary Figure S2

Supplementary Figure S3

Supplementary Figure S4

Supplementary Figure S5

Supplementary Figure S6

Supplementary Figure S7

Supplementary Figure S8

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