Advanced search
Publication Cover
Journal of Biomolecular Structure and Dynamics Volume 34, 2016 - Issue 6
Journal homepage
402
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Biased signaling: potential agonist and antagonist of PAR2

Kavita Kumari KakaralaCentre for Biotechnology and Bioinformatics (CBB), School of Life Sciences, Jawaharlal Nehru Institute of Advanced Studies (JNIAS), 6th Floor, Buddha Bhawan, M. G. Road, Secunderabad500003, Telangana, IndiaCorrespondence[email protected]
View further author information
&
Kaiser JamilCentre for Biotechnology and Bioinformatics (CBB), School of Life Sciences, Jawaharlal Nehru Institute of Advanced Studies (JNIAS), 6th Floor, Buddha Bhawan, M. G. Road, Secunderabad500003, Telangana, IndiaView further author information
Pages 1363-1376 | Received 16 Feb 2015, Accepted 31 Jul 2015, Published online: 19 Oct 2015
Supplemental material

Supplementary Material S3

Download MS Excel (186.9 KB)

Supplementary Material S2b

Download PDF (2.9 MB)

Supplementary Material S2a

Download PDF (3.7 MB)

Table S3. Snapshot of the data obtained from ensemble docking of ligand optimized PAR2 models with unique scaffolds of GLL database

Download PDF (692.7 KB)

Table S2. Glide score, Glide model score, Prime/MMGBSA score of Ligand (agonist/antagonist) optimized PAR2 model conformations generated after induced fit docking

Download PDF (37.1 KB)

Table S1. Molpdf, DOPE score, GA341 score, Molprobity analysis and ProSA scores of the PAR2 homology models [M1-M9] generated by EasyModeller

Download PDF (48.3 KB)

Figure S4: Ligands of different type docked to PAR2 models

Download PDF (265.3 KB)

Figure S3: Ligands of different type docked to PAR2 models

Download PDF (269.5 KB)

Figure S2: Binding site residues in antagonist (GB88) optimized PAR2 models (M1-M9).

Download TIFF Image (647.8 KB)

Figure S1: Binding site residues in agonist (GB110) optimized PAR2 models (M1-M9).

Download TIFF Image (579.8 KB)

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.