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Research Paper
Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation
Xi XuState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; ;Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Jie RenState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; ;Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Yinghe MaState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; ;Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Hongting LiuState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Quanjin RongState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Yifan FengState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Yameng WangState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Yu ChengState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; View further author information
, Ruijia GeThe Madeira School, McLean, VA, USAView further author information
, Zhiyu LiState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; ;Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; Correspondence[email protected]
View further author information
& View further author information
Jinlei BianState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China; ;Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; Correspondence[email protected]
View further author information
show allView further author information
Pages 250-263
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Received 03 Apr 2018, Accepted 16 May 2018, Published online: 02 Jan 2019
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