Supplemental material
Journal of Enzyme Inhibition and Medicinal Chemistry
Volume 34, 2019 - Issue 1
Research Paper
Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi
, , , , , , & 
show all
Marcelo Santos CastilhoPrograma de Pós-Graduação em Farmácia, Universidade Federal da Bahia, Salvador, BA, Brazil; ;Programa de Pós-Graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil; Correspondence[email protected]
http://orcid.org/0000-0002-9563-5679View further author information
http://orcid.org/0000-0002-9563-5679View further author information show allRelated Research Data
Structure of Recombinant Leishmania Donovani Pteridine Reductase Reveals a Disordered Active Site.
Source:
International Union of Crystallography (IUCr)
Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets
Source:
Elsevier BV
Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi
Source:
Elsevier
In Silico Screening, Structure-Activity Relationship, and Biologic Evaluation of Selective Pteridine Reductase Inhibitors Targeting Visceral Leishmaniasis
Source:
American Society for Microbiology
Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani.
Source:
Elsevier BV
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
Source:
Elsevier BV
Chaperonins govern growth of Escherichia coli at low temperatures.
Source:
Springer Science and Business Media LLC
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
Source:
Cambridge University Press (CUP)
Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: Temporal order and the roles of Asp27 and Tyr100
Source:
Proceedings of the National Academy of Sciences
Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.
Source:
American Chemical Society (ACS)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Source:
Elsevier BV
In vitro antileishmanial activity of fisetin flavonoid via inhibition of glutathione biosynthesis and arginase activity in Leishmania infantum.
Source:
Informa UK Limited
Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species.
Source:
Informa UK Limited
Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target.
Source:
Instituto Nacional de Salud
Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances.
Source:
(:unav)
CRYSTALLIZATION OF RECOMBINANT LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 (PTR1)
Source:
International Union of Crystallography (IUCr)
Considerations for the design and reporting of enzyme assays in high-throughput screening applications
Source:
The Authors. Published by Elsevier GmbH
pH homeostasis in Leishmania donovani amastigotes and promastigotes.
Source:
Proceedings of the National Academy of Sciences
Epidemiology of visceral leishmaniasis.
Source:
Dove Medical Press
Mutant PTR1 proteins from Leishmania tarentolae: comparative kinetic properties and active-site labeling.
Source:
Elsevier BV
Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.
Source:
American Chemical Society (ACS)
Folate metabolic pathways in Leishmania
Source:
Portland Press Ltd.
Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate
Source:
International Union of Crystallography (IUCr)
Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major.
Source:
American Chemical Society (ACS)
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence
Source:
American Chemical Society (ACS)
Linking provided by
