Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines

Marwa Sharakya Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, Egypt

Marwa Kamela Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, EgyptCorrespondence[email protected]

Marwa A. Azizb Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt

Mervat Omrana Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, Egypt

Monira M. Ragehc Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt

Khaled A. M. Abouzidb Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt;d Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt

Samia A. Shoumana Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, EgyptCorrespondence[email protected]

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Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines

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Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines

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