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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Jonathan Eliea Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
,
Omid Feizbakhshb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, FranceView further author information
,
Nathalie Desbanb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, FranceView further author information
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Béatrice Josselinb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, France;c Sorbonne Université/CNRS FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility) Station Biologique, Roscoff cedex, FranceView further author information
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Blandine Baratteb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, France;c Sorbonne Université/CNRS FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility) Station Biologique, Roscoff cedex, FranceView further author information
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Amandine Bescondb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, FranceView further author information
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Julien Duezb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, FranceView further author information
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Xavier Fantb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, FranceView further author information
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Stéphane Bachb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, France;c Sorbonne Université/CNRS FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility) Station Biologique, Roscoff cedex, FranceView further author information
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Dominique Maried Sorbonne Université/CNRS UMR7144, Station Biologique, Roscoff cedex, FranceView further author information
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Matthieu Placea Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
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Sami Ben Salaha Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
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Agnes Chartiera Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
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Sabine Berteina-Raboina Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
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Apirat Chaikuade Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;f Structure Genomics Consortium, Johann Wolfgang Goethe University, Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, GermanyView further author information
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Stefan Knappe Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;f Structure Genomics Consortium, Johann Wolfgang Goethe University, Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, GermanyView further author information
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Fabrice Carlesa Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
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Pascal Bonneta Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceView further author information
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Frédéric Burona Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceCorrespondence[email protected]
View further author information
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Sylvain Routiera Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, FranceCorrespondence[email protected]
View further author information
&
Sandrine Ruchaudb Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, FranceCorrespondence[email protected]
View further author information
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Pages 1840-1853 | Received 07 Jul 2020, Accepted 14 Sep 2020, Published online: 12 Oct 2020

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