sp²-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

Manuel González-Cuestaa Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, SpainView further author information

Irene Herrera-Gonzáleza Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, SpainView further author information

M. Isabel García-Morenoa Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, SpainView further author information

Roger A. Ashmusb Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, CanadaView further author information

David J. Vocadlob Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, CanadaView further author information

José M. García Fernándezc Instituto de Investigaciones Químicas (IIQ), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Sevilla, Sevilla, Spain

https://orcid.org/0000-0003-2323-6887 View further author information

Eiji Nanbad Organization for Research Initiative and Promotion, Tottori University, Yonago, JapanView further author information

Katsumi Higakid Organization for Research Initiative and Promotion, Tottori University, Yonago, JapanView further author information

Carmen Ortiz Melleta Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Sevilla, SpainCorrespondence[email protected]

https://orcid.org/0000-0002-7676-7721 View further author information

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sp²-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

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sp²-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease