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Research Article

Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells

Leyuan Chena Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, ChinaView further author information

Zhonghao Renb School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information

Yunze Zhangc School of Pharmacy, Tianjin Medical University, Tianjin, ChinaView further author information

Wenbin Houa Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, ChinaCorrespondence[email protected]
View further author information

Yiliang Lia Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, ChinaCorrespondence[email protected]
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Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells

Olaparib+A15-Merge.tif

A15-γH2AX- 7c.tif

Control-DAPI.tif

Olaparib-γ-H2AX.tif

Olaparib+A15-DAPI.tif

FigureS1B-And1.tif

FigureS1D-ª┬-actin.png

Figure3D-β-actin.tif

Olaparib+A15-Merge- 7c.tif

Control-Merge- 7c.tif

Olaparib-DAPI.tif

Figure3A-ª┬-actin.png

Figure3C-And1.tif

Olaparib+A15-γ-H2AX- 7c.tif

Control-DAPI- 7c.tif

A15-Merge- 7c.tif

FigureS1E-And1.tif

Figure4E-And1.tif

Figure7E-ª┬-actin.png

Figure4E-ª┬-actin.png

Control-γH2AX.tif

A15-DAPI- 7c.tif

FigureS1C-And1.tif

Olaparib-DAPI- 7c.tif

FigureS1D-And1.tif

A15-Merge.tif

Figure7E-BRCA2.tif

Figure7E-BRCA1.tif

Figure7E-And1.tif

FigureS1A-And1.tif

supplementary_data.docx

Figure3B-And1.tif

Figure3B-ª┬-actin.png

Olaparib-γ-H2AX- 7c.tif

Olaparib+A15-DAPI- 7c.tif

Control-Merge.tif

Figure7E-ª├-H2AX.tif

Figure3C-ª┬-actin.png

Figure3A-And1.tif

Olaparib+A15-γ-H2AX.tif

Figure3D-And-1.tif

Olaparib-Merge.tif

A15-γ-H2AX.tif

A15-DAPI.tif

FigureS1C-ª┬-actin.png

Olaparib-Merge- 7c.tif

FigureS1B-ª┬-actin.png

Control-γ-H2AX- 7c.tif

FigureS1A-ª┬-actin.png

FigureS1E-ª┬-actin.png

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