Supplemental material
Open access
4,286
Views
27
CrossRef citations to date
0
Altmetric
Research Paper
Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR
Bin YeDepartment of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Quan WangDepartment of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Haixia HuDepartment of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Yilin ShenDepartment of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Cui FanDepartment of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Penghui ChenShanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Yan MaShanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaView further author information
, Hao WuShanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaCorrespondence[email protected]
View further author information
& View further author information
Mingliang XiangDepartment of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Ear Institute, Shanghai Jiao tong University School of Medicine, Shanghai, ChinaCorrespondence[email protected]
View further author information
show allView further author information
Pages 998-1016
|
Received 08 Jan 2018, Accepted 24 Dec 2018, Published online: 01 Feb 2019
Related Research Data
The Reinnervation of Regenerated Hair Cells in the Basilar Papilla of Chicks after Kanamycin Ototoxicity
Source:
Informa UK Limited
Regulation of TFEB and V-ATPases by mTORC1
Source:
Wiley
Peroxisomes Get Loud: A Redox Antidote to Hearing Loss
Source:
Elsevier BV
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
Source:
EMBO
A RANKL-PKC -TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts
Source:
Cold Spring Harbor Laboratory
Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Oxidative Stress, Inflammation, and Autophagic Stress as the Key Mechanisms of Premature Age-Related Hearing Loss in SAMP8 Mouse Cochlea
Source:
Mary Ann Liebert Inc
Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR
Source:
Figshare
Kanamycin Damages Early Postnatal, but Not Adult Spiral Ganglion Neurons
Source:
Springer Nature
Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
Source:
Elsevier BV
Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals
Source:
Springer Nature
Survival of Spiral Ganglion Cells in Profound Sensorineural Hearing Loss: Implications for Cochlear Implantation
Source:
SAGE Publications
Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma
Source:
Elsevier BV
Inner Hair Cells Are Not Required for Survival of Spiral Ganglion Neurons in the Adult Cochlea
Source:
Society for Neuroscience
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Source:
Springer Science and Business Media LLC
Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A Generation and Amyloid Plaque Pathogenesis
Source:
Society for Neuroscience
Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss
Source:
Hindawi Limited
Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection
Source:
Asian Pacific Organization for Cancer Prevention
Patterns of degeneration in the human cochlear nerve
Source:
Elsevier BV
Free radical scavenger protects against inner hair cell loss after cochlear ischemia.
Source:
Ovid Technologies (Wolters Kluwer Health)
Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma
Source:
Elsevier BV
NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease
Source:
Springer Nature
Sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation will increase in lipopolysaccharide-induced inflammation in vitro model
Source:
Springer Nature
Lysosomal impairment in Parkinson's disease
Source:
Wiley-Blackwell
Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss
Source:
Elsevier BV
Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus
Source:
Elsevier BV
Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR
Source:
Taylor & Francis
PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease
Source:
Informa UK Limited
Oxidative stress: a concept in redox biology and medicine
Source:
Elsevier BV
Efr3a Insufficiency Attenuates the Degeneration of Spiral Ganglion Neurons after Hair Cell Loss
Source:
Frontiers Media SA
Aging and Hearing Health: The Life-course Approach.
Source:
Oxford University Press (OUP)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Source:
Springer Nature
Consonant recognition as a function of the number of stimulation channels in the Hybrid short-electrode cochlear implant
Source:
Acoustical Society of America (ASA)
Topographic and quantitative evaluation of gentamicin-induced damage to peripheral innervation of mouse cochleae
Source:
Elsevier BV
Oxidative stress, glutamate, and neurodegenerative disorders
Source:
American Association for the Advancement of Science (AAAS)
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links
Source:
Wiley-Blackwell
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Source:
Elsevier BV
Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR
Source:
Taylor & Francis
The role of Efr3a in age-related hearing loss
Source:
Elsevier BV
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Source:
Springer Science and Business Media LLC
Age-regulated function of autophagy in the mouse inner ear
Source:
Elsevier BV
Autophagy protects auditory hair cells against neomycin-induced damage
Source:
Informa UK Limited
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.
Source:
Oxford University Press (OUP)
Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation☆
Source:
Elsevier BV
L-cysteine attenuates peroxynitrite-elicited cytotoxicity to spiral ganglion neurons: possible relation to hearing loss
Source:
Informa UK Limited
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
Source:
Informa UK Limited
Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss
Source:
Elsevier BV
Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss
Source:
SAGE Publications
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.