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Autophagy Volume 18, 2022 - Issue 7
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Brief Report

The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males

Susanna Croci1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Mary Anna Venneri3 Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyView further author information
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Stefania Mantovani4 Division of Clinical Immunology and Infectious Diseases, Department of Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyORCID Iconhttps://orcid.org/0000-0002-5885-2842View further author information
ORCID Icon,
Chiara Fallerini1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Elisa Benetti2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Nicola Picchiotti5 DIISM-SAILAB, University of Siena, Siena, Italy;6 Department of Mathematics, University of Pavia, Pavia, ItalyView further author information
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Federica Campolo3 Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyView further author information
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Francesco Imperatore7 Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Core Research Laboratory, Via Fiorentina, Siena, Italy;8 Consiglio Nazionale delle Ricerche, Istituto DI Fisiologia Clinica, Siena, ItalyView further author information
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Maria Palmieri1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Sergio Daga1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Chiara Gabbi9 Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, SwedenView further author information
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Francesca Montagnani2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy;10 Department of Medical Sciences, Infectious and Tropical Diseases Unit, Azienda Ospedaliera Universitaria Senese, Siena, ItalyView further author information
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Giada Beligni1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Ticiana D.J. Farias11 Division of Biomedical Informatics and Personalized Medicine, and Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
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Miriam Lucia Carriero1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Laura Di Sarno1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Diana Alaverdian1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Sigrid Aslaksen12 Department of Clinical Science, Universty of Bergen and K.G. Jebsen Center for Autoimmune Diseases, University of Bergen, Bergen, NorwayView further author information
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Maria Vittoria Cubellis13 Department of Biology, Università Degli Studi di Napoli “Federico II”, Napoli, ItalyView further author information
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Ottavia Spiga14 Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, ItalyORCID Iconhttps://orcid.org/0000-0002-0263-7107View further author information
ORCID Icon,
Margherita Baldassarri1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Francesca Fava1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Paul J. Norman11 Division of Biomedical Informatics and Personalized Medicine, and Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
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Elisa Frullanti1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Andrea M. Isidori3 Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-9037-5417View further author information
ORCID Icon,
Antonio Amoroso15 Department of Medical Sciences, University of Turin, Turin, Italy;16 Immunogenetics and Transplant Biology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, ItalyView further author information
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Francesca Mari1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy;17 Genetica Medica, Azienda Ospedaliero-Universitaria Senese, ItalyView further author information
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Simone Furini2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Mario U Mondelli4 Division of Clinical Immunology and Infectious Diseases, Department of Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;18 Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyORCID Iconhttps://orcid.org/0000-0003-1811-3153View further author information
ORCID Icon,
GEN-COVID multicenter study1 Medical Genetics, University of Siena, Siena, ItalyView further author information
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Mario Chiariello7 Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Core Research Laboratory, Via Fiorentina, Siena, Italy;8 Consiglio Nazionale delle Ricerche, Istituto DI Fisiologia Clinica, Siena, ItalyCorrespondence[email protected]
View further author information
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Alessandra Renieri1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy;17 Genetica Medica, Azienda Ospedaliero-Universitaria Senese, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0846-9220View further author information
ORCID Icon &
Ilaria Meloni1 Medical Genetics, University of Siena, Siena, Italy;2 Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, ItalyView further author information
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Pages 1662-1672 | Received 23 Mar 2021, Accepted 14 Oct 2021, Published online: 29 Dec 2021

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