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Autophagy Volume 18, 2022 - Issue 8
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Research Paper

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Jingyue Yaoa State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Jubo Wangb Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Ye Xua State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Qinglong Guoa State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Yuening Suna State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Jian Liua State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Sichan Lia State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
,
Yongjian Guoc School of Biopharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaView further author information
&
Libin Weia State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, The People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 1879-1897 | Received 29 Mar 2021, Accepted 08 Nov 2021, Published online: 10 Dec 2021

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