Autophagy, Volume 18, Issue 8 (2022)

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Autophagy, Volume 18, Issue 8 (2022)

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Editor’s Corner

Editorial
A “short-cut” response of autophagy to oxidative stress: oxygen-dependent activity of a lysine demethylase guides the activity of ULK1 during hypoxia
Ge Yu & Daniel J. Klionsky
Pages: 1749-1751
Published online: 26 Jun 2022
AbstractforA “short-cut” response of autophagy to oxidative stress: oxygen-dependent activity of a lysine demethylase guides the activity of ULK1 during hypoxia | Full Text | References | PDF (192.5 KB) | EPUB
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Brief Report

Brief Report
AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability
Martina Di Rienzo, Alessandra Romagnoli, Fabiola Ciccosanti, Giulia Refolo, Veronica Consalvi, Giuseppe Arena, Enza Maria Valente, Mauro Piacentini & Gian Maria Fimia
Pages: 1752-1762
Published online: 19 Nov 2021
AbstractforAMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Research Paper

Article
HYPK coordinates degradation of polyneddylated proteins by autophagy
Debasish Kumar Ghosh & Akash Ranjan
Pages: 1763-1784
Published online: 26 Nov 2021
AbstractforHYPK coordinates degradation of polyneddylated proteins by autophagy | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
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Research paper

Article
Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
Clivia Lisowski, Jane Dias, Susana Costa, Ricardo Jorge Silva, Miguel Mano & Ana Eulalio
Pages: 1785-1800
Published online: 15 Nov 2021
AbstractforDysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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Research Paper

Article
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy
Sheng-Li Ming, Shuang Zhang, Qi Wang, Lei Zeng, Lu-Yu Zhou, Meng-Di Wang, Ying-Xian Ma, Li-Qiang Han, Kai Zhong, He-Shui Zhu, Yi-Lin Bai, Guo-Yu Yang, Jiang Wang & Bei-Bei Chu
Pages: 1801-1821
Published online: 25 Nov 2021
AbstractforInhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
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Article
Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers
Shaoyang Zhang, Xiufeng Liu, Saleh Abdulmomen Ali Mohammed, Hui Li, Wanhua Cai, Wen Guan, Daiyun Liu, Yanli Wei, Dade Rong, Ying Fang, Farhan Haider, Haimei Lv, Ziwei Jin, Xiaomin Chen, Zhuomao Mo, Lujie Li, Shulan Yang & Haihe Wang
Pages: 1822-1840
Published online: 06 Dec 2021
AbstractforAdaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers | Full Text | References | PDF (10 MB) | EPUB | Supplemental
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Open Access
Article
Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis
Junsheng Lou, Xiangyang Wang, Haojie Zhang, Gaoxiang Yu, Jian Ding, Xuwei Zhu, Yao Li, Yaosen Wu, Hui Xu, Huazi Xu, Weiyang Gao, Jian Xiao & Kailiang Zhou
Pages: 1841-1863
Published online: 07 Dec 2021
AbstractforInhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
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Article
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1
Tong Shao, Hanni Ke, Ran Liu, Lan Xu, Shuang Han, Xiruo Zhang, Yujie Dang, Xue Jiao, Wei Li, Zi-Jiang Chen, Yingying Qin & Shidou Zhao
Pages: 1864-1878
Published online: 13 Jan 2022
AbstractforAutophagy regulates differentiation of ovarian granulosa cells through degradation of WT1 | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Article
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma
Jingyue Yao, Jubo Wang, Ye Xu, Qinglong Guo, Yuening Sun, Jian Liu, Sichan Li, Yongjian Guo & Libin Wei
Pages: 1879-1897
Published online: 10 Dec 2021
AbstractforCDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
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Article
ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer
Tom G. Keulers, Alexander Koch, Marike W. van Gisbergen, Lydie M.O. Barbeau, Marijke I. Zonneveld, Monique C. de Jong, Kim G.M. Savelkouls, Roel G. Wanders, Johan Bussink, Veerle Melotte & Kasper M.A. Rouschop
Pages: 1898-1914
Published online: 14 Dec 2021
AbstractforATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
Autophagy modulates cell fate decisions during lineage commitment
Kulbhushan Sharma, Nagham T. Asp, Sean Harrison, Richard Siller, Saphira F. Baumgarten, Swapnil Gupta, Maria E Chollet, Elisabeth Andersen, Gareth J. Sullivan & Anne Simonsen
Pages: 1915-1931
Published online: 19 Dec 2021
AbstractforAutophagy modulates cell fate decisions during lineage commitment | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Open Access
Article
Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway
Yanhong Xing, Xiangqing Wei, Yucheng Liu, Meng-Meng Wang, Zhongheng Sui, Xinyan Wang, Wucheng Zhu, Mengmei Wu, Chen Lu, Yuan-Hui Fei, Yi Jiang, Yang Zhang, Yuqing Wang, Feng Guo, Jun-Li Cao, Jiansong Qi & Wuyang Wang
Pages: 1932-1954
Published online: 08 Dec 2021
AbstractforAutophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
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Article
SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain
Peng Yin, Dazhang Bai, Fuyu Deng, Chen Zhang, Qingqing Jia, Longhong Zhu, Laiqiang Chen, Bang Li, Xiangyu Guo, Jianmeng Ye, Zhiqiang Tan, Lu Wang, Shihua Li & Xiao-Jiang Li
Pages: 1955-1968
Published online: 22 Dec 2021
AbstractforSQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 1239 Views
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Article
2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8
Dage Sun, Ning Kong, Sujie Dong, Xiaoyong Chen, Wenzhen Qin, Hua Wang, Yajuan Jiao, Huanjie Zhai, Liwei Li, Fei Gao, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong & Tongling Shan
Pages: 1969-1981
Published online: 29 Dec 2021
Abstractfor2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8 | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 2969 Views
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Article
Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency
Fangyang Wang, Ying Yang, Gabriel Boudagh, Eeva-Liisa Eskelinen, Daniel J. Klionsky & Sami N. Malek
Pages: 1982-2000
Published online: 24 Mar 2022
AbstractforFollicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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Autophagic Punctum

Article Commentary
The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D
Di Liu, Shouheng Jin & Jun Cui
Pages: 2001-2002
Published online: 23 Mar 2022
AbstractforThe TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D | Full Text | References | PDF (295.7 KB) | EPUB
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Article Commentary
Proteomic profiling shows mitochondrial nucleoids are autophagy cargo in neurons: implications for neuron maintenance and neurodegenerative disease
Juliet Goldsmith & Erika L. F. Holzbaur
Pages: 2003-2005
Published online: 29 Mar 2022
AbstractforProteomic profiling shows mitochondrial nucleoids are autophagy cargo in neurons: implications for neuron maintenance and neurodegenerative disease | Full Text | References | PDF (523.4 KB) | EPUB
  • 1114 Views
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Article Commentary
Crosstalk between the innate immune system and selective autophagy in hepatitis B virus infection
Kei Miyakawa, Sundararaj Stanleyraj Jeremiah, Michinaga Ogawa, Mayuko Nishi, Makoto Ohnishi & Akihide Ryo
Pages: 2006-2007
Published online: 05 Apr 2022
AbstractforCrosstalk between the innate immune system and selective autophagy in hepatitis B virus infection | Full Text | References | PDF (326.4 KB) | EPUB
  • 1202 Views
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Article Commentary
Regulation of oxidative stress-induced autophagy by ATG9A ubiquitination
Yi-Ting Wang & Guang-Chao Chen
Pages: 2008-2010
Published online: 12 Apr 2022
AbstractforRegulation of oxidative stress-induced autophagy by ATG9A ubiquitination | Full Text | References | PDF (473.2 KB) | EPUB
  • 1795 Views
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Article Commentary
Local biogenesis of autophagic vesicles in neuronal dendrites facilitates long-term synaptic depression
Akrivi-Dimitra Daskalaki, Emmanouela Kallergi, Angeliki Kolaxi & Vassiliki Nikoletopoulou
Pages: 2011-2012
Published online: 07 Apr 2022
AbstractforLocal biogenesis of autophagic vesicles in neuronal dendrites facilitates long-term synaptic depression | Full Text | References | PDF (509.3 KB) | EPUB
  • 695 Views
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Article Commentary
Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer
Kun Gao, Qing Shi, Yajuan Liu & Chenji Wang
Pages: 2013-2015
Published online: 19 Apr 2022
AbstractforEnhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer | Full Text | References | PDF (352.7 KB) | EPUB
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