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Autophagy Volume 18, 2022 - Issue 9
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Research Paper

Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification

Hung Chana Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Qing Lia Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
,
Xiansong Wanga Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Wing Yingzhi Liua Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Wei Hua Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Judeng Zenga Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Chuan Xiea Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Thomas Ngai Yeung Kwongc Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;e Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Idy Hiu Ting Hoa Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Xiaodong Liua Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Huarong Chena Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Jun Yuc Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;e Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;f Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Ho Kob Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;e Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Raphael Chiu Yeung Chang Department of Microbiology, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Margaret Ipf Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;g Department of Microbiology, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaORCID Iconhttps://orcid.org/0000-0003-1291-6537View further author information
ORCID Icon,
Tony Gina Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Alfred Sze Lok Chengd State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;h School of Biomedical Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Lin Zhanga Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;e Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Matthew Tak Vai Chana Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaCorrespondence[email protected] [email protected]
View further author information
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Sunny Hei Wongc Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;e Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;f Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;i Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3354-9310View further author information
ORCID Icon &
William Ka Kei Wua Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;b Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;c Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;d State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, China;f Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong KongSpecial Administrative Region, ChinaView further author information
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Pages 2050-2067 | Received 09 Jul 2021, Accepted 06 Dec 2021, Published online: 06 Jan 2022

Related Research Data

Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification
Source: Taylor & Francis

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