Supplemental material
Epigenetics
Volume 13, 2018 - Issue 10-11
Open access
1,844
Views
13
CrossRef citations to date
0
Altmetric
Research Paper
The proto CpG island methylator phenotype of sessile serrated adenomas/polyps
Hannah R. ParkerInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
http://orcid.org/0000-0003-1691-5216View further author information
Stephany OrjuelaInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland;Institute of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, SwitzerlandView further author information
, Andreia Martinho OliveiraInstitute of Molecular Cancer Research, University of Zurich, Zurich, SwitzerlandView further author information
, Fabrizio CereattiGastroenterology and Endoscopy Unit, Hospital of Cremona, Cremona, ItalyView further author information
, Matthias SauterDivision of Gastroenterology, Triemli Hospital, Zurich, SwitzerlandView further author information
, Henriette HeinrichDivision of Gastroenterology, Triemli Hospital, Zurich, SwitzerlandView further author information
, Giulia TanziDivision of Pathology, Hospital of Cremona, Cremona, ItalyView further author information
, Achim WeberInstitute of Surgical Pathology, University of Zurich, Zurich, SwitzerlandView further author information
, Paul KomminothDivision of Pathology, Triemli Hospital, Zurich, SwitzerlandView further author information
, Stephan VavrickaDivision of Gastroenterology, Triemli Hospital, Zurich, SwitzerlandView further author information
, Luca AlbaneseInstitute of Molecular Cancer Research, University of Zurich, Zurich, SwitzerlandView further author information
, Federico BuffoliGastroenterology and Endoscopy Unit, Hospital of Cremona, Cremona, ItalyView further author information
, Mark D. RobinsonInstitute of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland
http://orcid.org/0000-0002-3048-5518View further author information
Giancarlo MarraInstitute of Molecular Cancer Research, University of Zurich, Zurich, SwitzerlandCorrespondence[email protected] [email protected]
http://orcid.org/0000-0003-1080-4320View further author information
Pages 1088-1105
|
Received 20 Jul 2018, Accepted 22 Oct 2018, Published online: 22 Nov 2018
Related Research Data
Microsatellite Instability in Interval Colon Cancers
Source:
Elsevier BV
Microsatellite Instability in Colorectal Cancer
Source:
Elsevier BV
Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
Source:
Elsevier BV
Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma
Source:
BMJ
The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis
Source:
Springer Nature
Platform-independent gene expression signature differentiates sessile serrated adenomas/polyps and hyperplastic polyps of the colon
Source:
Springer Nature
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Source:
Springer Science and Business Media LLC
Epigenetic silencing of monoallelically methylated miRNA loci in precancerous colorectal lesions
Source:
Springer Nature
The BRAF Oncoprotein Functions through the Transcriptional Repressor MAFG to Mediate the CpG Island Methylator Phenotype
Source:
Elsevier BV
Genome-scale analysis of aberrant DNA methylation in colorectal cancer
Source:
Cold Spring Harbor Laboratory
Variation in Pathologist Classification of Colorectal Adenomas and Serrated Polyps
Source:
Ovid Technologies (Wolters Kluwer Health)
Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.
Source:
Elsevier Inc.
A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas
Source:
American Association for Cancer Research (AACR)
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
Source:
Elsevier BV
Serrated adenoma of the colorectum and the DNA-methylator phenotype
Source:
Springer Nature
BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis
Source:
eLife Sciences Publications, Ltd
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
Source:
Oxford University Press (OUP)
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
Source:
Springer Nature
Critical Appraisal of the Diagnosis of the Sessile Serrated Adenoma
Source:
Ovid Technologies (Wolters Kluwer Health)
Cancer epigenetics reaches mainstream oncology
Source:
Springer Nature
Update on the Paris Classification of Superficial Neoplastic Lesions in the Digestive Tract
Source:
Georg Thieme Verlag KG
Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance
Source:
BMJ
Incomplete Polyp Resection During Colonoscopy—Results of the Complete Adenoma Resection (CARE) Study
Source:
Elsevier BV
RNA Sequencing of Sessile Serrated Colon Polyps Identifies Differentially Expressed Genes and Immunohistochemical Markers
Source:
Public Library of Science (PLoS)
Insulator dysfunction and oncogene activation in IDH mutant gliomas
Source:
Springer Science and Business Media LLC
Non-canonical functions of the DNA methylome in gene regulation
Source:
Portland Press Ltd.
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Source:
Springer Science and Business Media LLC
Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.
Source:
Public Library of Science
BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
Source:
BMJ
Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype
Source:
American Association for Cancer Research (AACR)
Immunohistochemical Analysis Reveals High Frequency of PMS2 Defects in Colorectal Cancer
Source:
Elsevier BV
Serrated neoplasia—role in colorectal carcinogenesis and clinical implications
Source:
Springer Nature
CpG islands and the regulation of transcription
Source:
Cold Spring Harbor Laboratory
Frequent CpG Island Methylation in Serrated Adenomas of the Colorectum
Source:
Elsevier BV
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Source:
Springer Science and Business Media LLC
The CIMP Phenotype inBRAFMutant Serrated Polyps from a Prospective Colonoscopy Patient Cohort
Source:
Hindawi Limited
DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas
Source:
Springer Science and Business Media LLC
Distinct CpG island methylation profiles andBRAFmutation status in serrated and adenomatous colorectal polyps
Source:
Wiley
Gene expression profiling of serrated polyps identifies annexin A10 as a marker of a sessile serrated adenoma/polyp
Source:
Wiley-Blackwell
The Epigenomics of Cancer
Source:
Elsevier BV
Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma End Points
Source:
Ovid Technologies (Wolters Kluwer Health)
Sessile serrated adenoma shares similar genetic and epigenetic features with microsatellite unstable colon cancer in a location-dependent manner
Source:
Spandidos Publications
Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer
Source:
Elsevier BV
Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands
Source:
EMBO
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Source:
American Association for the Advancement of Science (AAAS)
Use of restriction enzymes to study eukaryotic DNA methylation: II. The symmetry of methylated sites supports semi-conservative copying of the methylation pattern.
Source:
Elsevier BV
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Source:
Elsevier BV
The serrated pathway to colorectal carcinoma: current concepts and challenges
Source:
Wiley-Blackwell
Defective DNA Mismatch Repair Determines a Characteristic Transcriptional Profile in Proximal Colon Cancers
Source:
Elsevier BV
Gastric-type expression signature in serrated pathway–associated colorectal tumors
Source:
Elsevier BV
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Source:
Proceedings of the National Academy of Sciences
Quantitative evaluation of CpG island methylation in hyperplastic polyps
Source:
Springer Nature
Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.
Source:
Oxford University Press (OUP)
Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract
Source:
Wiley-Blackwell
DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer
Source:
Springer Nature
Conserved role of intragenic DNA methylation in regulating alternative promoters
Source:
Springer Nature
A DNA hypermethylation module for the stem/progenitor cell signature of cancer
Source:
Cold Spring Harbor Laboratory
The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer.
Source:
Elsevier BV
DNA methylation dynamics in health and disease
Source:
Springer Nature
Annexin A10 is a marker for the serrated pathway of colorectal carcinoma
Source:
Springer Nature
The epigenetic progenitor origin of human cancer
Source:
Springer Nature
Molecular Dissection of Premalignant Colorectal Lesions Reveals Early Onset of the CpG Island Methylator Phenotype
Source:
Elsevier BV
Detection of significantly differentially methylated regions in targeted bisulfite sequencing data
Source:
Oxford University Press (OUP)
Aging and epigenetic drift: a vicious cycle
Source:
American Society for Clinical Investigation
CpG island methylator phenotype in colorectal cancer
Source:
Proceedings of the National Academy of Sciences
A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention
Source:
Elsevier BV
DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment
Source:
Springer Nature
Epigenetic stem cell signature in cancer.
Source:
Springer Science and Business Media LLC
Salmon provides fast and bias-aware quantification of transcript expression
Source:
Springer Science and Business Media LLC
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.