Supplemental material
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related Research Data
Effect of the Structural Water on the Mechanical Properties of Collagen-like Microfibrils: A Molecular Dynamics Study
Source:
Springer Nature
Mechanisms of mechanosensing — mechanosensitive channels, function and re-engineering
Source:
Elsevier BV
Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction
Source:
Springer Nature
Role of Intermolecular Forces in Defining Material Properties of Protein Nanofibrils
Source:
American Association for the Advancement of Science (AAAS)
Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution
Source:
Springer Nature
Energy landscape, structure and rate effects on strength properties of alpha-helical proteins
Source:
IOP Publishing
Molecular Dynamics Study of Gating in the Mechanosensitive Channel of Small Conductance MscS
Source:
Elsevier BV
Structure and stability of the C-terminal helical bundle of theE. colimechanosensitive channel of large conductance
Source:
Wiley-Blackwell
Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model
Source:
Elsevier BV
Mechanical Strength of 17 134 Model Proteins and Cysteine Slipknots
Source:
Public Library of Science (PLoS)
Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS
Source:
Proceedings of the National Academy of Sciences
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
Source:
Springer Nature America, Inc
Membrane proteins bind lipids selectively to modulate their structure and function
Source:
Springer Nature
Biophysical implications of lipid bilayer rheometry for mechanosensitive channels
Source:
Proceedings of the National Academy of Sciences
Magnetic nanoparticles for “smart liposomes”
Source:
Springer Nature
Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells
Source:
Public Library of Science (PLoS)
Lipid–protein interactions: Lessons learned from stress
Source:
Elsevier BV
Analytic models for mechanotransduction: Gating a mechanosensitive channel
Source:
Proceedings of the National Academy of Sciences
Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations
Source:
Public Library of Science (PLoS)
VMD: Visual molecular dynamics
Source:
Elsevier BV
Estimation of Potentials of Mean Force from Nonequilibrium Pulling Simulations Using Both Minh-Adib Estimator and Weighted Histogram Analysis Method
Source:
American Chemical Society (ACS)
C-Terminal Charged Cluster of MscL, RKKEE, Functions as a pH Sensor
Source:
Elsevier BV
The Combined Effect of Hydrophobic Mismatch and Bilayer Local Bending on the Regulation of Mechanosensitive Ion Channels
Source:
Public Library of Science (PLoS)
Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures.
Source:
American Chemical Society (ACS)
The effect of local bending on gating of MscL using a representative volume element and finite element simulation
Source:
Informa UK Limited
Hierarchies, multiple energy barriers, and robustness govern the fracture mechanics of -helical and beta-sheet protein domains
Source:
Proceedings of the National Academy of Sciences
Bacterial mechanosensitive channels: integrating physiology, structure and function
Source:
Elsevier BV
Stable Single α-Helices Are Constant Force Springs in Proteins
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Determination of the elastic modulus of native collagen fibrils via radial indentation
Source:
AIP Publishing
EPR Approaches to Ion Channel Structure and Function
Source:
John Wiley & Sons, Ltd
Elasticity and unfolding of single molecules of the giant muscle protein titin
Source:
Springer Nature
Steered molecular dynamics simulation of conformational changes of immunoglobulin domain I27 interprete atomic force microscopy observations
Source:
Elsevier BV
Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL
Source:
Springer Nature
Comparative analysis of nanomechanics of protein filaments under lateral loading
Source:
Royal Society of Chemistry (RSC)
Microrheological Characterization of Collagen Systems: From Molecular Solutions to Fibrillar Gels
Source:
Public Library of Science (PLoS)
Dynamic allostery of protein alpha helical coiled-coils
Source:
The Royal Society
The Phyre2 web portal for protein modeling, prediction and analysis
Source:
Springer Nature
Multiple Mechanosensitive Ion Channels from Escherichia coli, Activated at Different Thresholds of Applied Pressure
Source:
Springer Science and Business Media LLC
Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel
Source:
eLife Sciences Publications, Ltd
Emerging roles for lipids in shaping membrane-protein function
Source:
Springer Nature
Improving the Design of a MscL-Based Triggered Nanovalve
Source:
MDPI AG
Structural Determinants of MscL Gating Studied by Molecular Dynamics Simulations
Source:
The Biophysical Society. Published by Elsevier Inc.
Hydrophilicity of a Single Residue within MscL Correlates with Increased Channel Mechanosensitivity
Source:
Elsevier BV
Open channel structure of MscL and the gating mechanism of mechanosensitive channels
Source:
Springer Nature
A Light-Actuated Nanovalve Derived from a Channel Protein
Source:
American Association for the Advancement of Science (AAAS)
Structural Investigation of MscL Gating Using Experimental Data and Coarse Grained MD Simulations
Source:
Public Library of Science (PLoS)
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels
Source:
Springer Nature America, Inc
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
Source:
Springer Nature
Atomistic and continuum modeling of mechanical properties of collagen: Elasticity, fracture, and self-assembly
Source:
Cambridge University Press (CUP)
Hierarchical Structure and Nanomechanics of Collagen Microfibrils from the Atomistic Scale Up
Source:
American Chemical Society (ACS)
Synthesis and utilization of reversible and irreversible light-activated nanovalves derived from the channel protein MscL
Source:
Springer Nature
Remembering Mechanosensitivity of NMDA Receptors
Source:
Frontiers Media SA
Molecular Dynamics Study of MscL Interactions with a Curved Lipid Bilayer
Source:
Elsevier BV
A possible unifying principle for mechanosensation
Source:
Springer Nature
Theoretical and computational hierarchical nanomechanics of protein materials: Deformation and fracture
Source:
Elsevier BV
The elasticity of α-helices
Source:
AIP Publishing
Structural Determinants of Cadherin-23 Function in Hearing and Deafness
Source:
Elsevier BV
Gating mechanism of mechanosensitive channel of large conductance: a coupled continuum mechanical-continuum solvation approach
Source:
Springer Nature
A Finite Element Framework for Studying the Mechanical Response of Macromolecules: Application to the Gating of the Mechanosensitive Channel MscL
Source:
Elsevier BV
The key event in force-induced unfolding of Titin's immunoglobulin domains.
Source:
The Biophysical Society. Published by Elsevier Inc.
Coarse-grained simulation: a high-throughput computational approach to membrane proteins
Source:
Portland Press Ltd.
Hydration properties of mechanosensitive channel pores define the energetics of gating
Source:
IOP Publishing
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
Source:
Oxford University Press (OUP)
Elastic properties, Young's modulus determination and structural stability of the tropocollagen molecule: a computational study by steered molecular dynamics
Source:
Elsevier BV
Linking provided by
