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Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies
Rajkumar GanesanBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT., USACorrespondence[email protected] [email protected]
http://orcid.org/0000-0002-3431-9664
http://orcid.org/0000-0002-3431-9664, , , , , , Jennifer AhlbergBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT., USAhttp://orcid.org/0000-0002-2892-4163
http://orcid.org/0000-0002-2892-4163, , Simon RobertsBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT., USAhttp://orcid.org/0000-0002-5743-3769
http://orcid.org/0000-0002-5743-3769, , , , , , Priyanka GuptaBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT., USAhttp://orcid.org/0000-0001-6483-3069
http://orcid.org/0000-0001-6483-3069, , , , Rachel Kroe-BarrettBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT., USAhttp://orcid.org/0000-0003-1413-1223
http://orcid.org/0000-0003-1413-1223, , Sanjaya SinghBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT., USAhttp://orcid.org/0000-0002-9119-7966
http://orcid.org/0000-0002-9119-7966 & show allRelated Research Data
Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk
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Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis
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Tailoring kinetics of antibodies using focused combinatorial libraries.
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Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation.
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Mutation analysis of IL36RN in a Chinese Daur family with generalized pustular psoriasis
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Scoping review of biological treatment of deficiency of interleukin-36 receptor antagonist (DITRA) in children and adolescents.
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A new nomenclature for IL-1-family genes.
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IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.
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Mutation analysis of the IL36RN gene in Chinese patients with generalized pustular psoriasis with/without psoriasis vulgaris.
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Interleukin (IL)-1F6, IL-1F8, and IL-1F9 Signal through IL-1Rrp2 and IL-1RAcP to Activate the Pathway Leading to NF-κB and MAPKs
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American Society for Biochemistry & Molecular Biology (ASBMB)
A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
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Springer Science and Business Media LLC
IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis
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IL-1 family expression in psoriasis keratinocytes
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Mutations in IL36RN in Patients with Generalized Pustular Psoriasis
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Elsevier BV
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.
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American Society for Biochemistry & Molecular Biology (ASBMB)
Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells
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Elsevier BV
Correspondence
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Wiley
IL36RN mutations underlie impetigo herpetiformis.
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The Society for Investigative Dermatology, Inc.
The genetic background of generalized pustular psoriasis: IL36RN mutations and CARD14 gain-of-function variants.
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Alterations of plasma inflammatory biomarkers in the healthy and chronic obstructive pulmonary disease patients with or without acute exacerbation
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Elsevier BV
What's in a Name?
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American Medical Association (AMA)
Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations
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Wiley
Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients
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Springer Science and Business Media LLC
Loss of IL36RN Function Does Not Confer Susceptibility to Psoriasis Vulgaris
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Elsevier BV
Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis.
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Correspondence
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Disrupting the IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis
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HAL CCSD
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