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An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
Shan ChungDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USACorrespondence[email protected]
http://orcid.org/0000-0002-5494-2103View further author information
Van NguyenDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USAView further author information
, Yuwen Linda LinDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USA
http://orcid.org/0000-0001-8390-6964View further author information
Julien Lafrance-VanasseDepartment of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA
http://orcid.org/0000-0001-8807-6277View further author information
Suzie J. ScalesDepartment of Molecular Biology, Genentech Inc., South San Francisco, CA, USA
http://orcid.org/0000-0003-2544-0283View further author information
Kevin LinDepartment of Analytical Operations, Genentech Inc., South San Francisco, CA, USAView further author information
, Rong DengDepartment of Clinical Pharmacology, Genentech Inc., South San Francisco, CA, USAView further author information
, Kathi WilliamsDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USAView further author information
, Gizette SperindeDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USAView further author information
, Juan Jenny LiDepartment of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USAView further author information
, Kai ZhengDepartment of Late Stage Pharmaceutical Development, Genentech Inc., South San Francisco, CA, USAView further author information
, Siddharth SukumaranDepartment of Pharmacokinetics & Pharmacodynamics, Genentech Inc., South San Francisco, CA, USAView further author information
, Devin TesarDepartment of Drug Delivery, Genentech Inc., South San Francisco, CA, USAView further author information
, James A. ErnstDepartment of Protein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
, Saloumeh FischerDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USAView further author information
, Greg A. LazarDepartment of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
, Saileta PrabhuDepartment of Pharmacokinetics & Pharmacodynamics, Genentech Inc., South San Francisco, CA, USAView further author information
& An SongDepartment of BioAnalytical Sciences, Genentech Inc., South San Francisco, CA, USA
http://orcid.org/0000-0001-7446-4359View further author information
Pages 942-955
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Received 20 Oct 2018, Accepted 08 Mar 2019, Published online: 29 Apr 2019
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