mAbs, Volume 11, Issue 5 (2019)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

mAbs, Volume 11, Issue 5 (2019)

See all volumes and issues
Vol 16, 2024 Vol 15, 2023 Vol 14, 2022 Vol 13, 2021 Vol 12, 2020 Volume 11, 2019 Vol 10, 2018 Vol 9, 2017 Vol 8, 2016 Vol 7, 2015 Vol 6, 2014 Vol 5, 2013 Vol 4, 2012 Vol 3, 2011 Vol 2, 2010 Vol 1, 2009
Download citations Download PDFs Download issue

Perspective

Article Commentary
Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico
Maximiliano Vásquez, Eric Krauland, Laura Walker, Dane Wittrup & Tillman Gerngross
Pages: 803-808
Published online: 20 May 2019
AbstractforConnecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 19932 Views
  • 5 CrossRef citations
  • 0Altmetric
Open Access
Article Commentary
De novo discovery of antibody drugs – great promise demands scrutiny
William J.J. Finlay & Alexey A. Lugovskoy
Pages: 809-811
Published online: 06 Jun 2019
AbstractforDe novo discovery of antibody drugs – great promise demands scrutiny | Full Text | References | PDF (281.2 KB) | EPUB
  • 3546 Views
  • 1 CrossRef citations
  • 0Altmetric
Free Access

Meeting Report

Report
Targets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6th antibody industrial symposium, June 25-26, 2018, Montpellier, France
Pierre Martineau, Hervé Watier, Andre Pèlegrin & Andrei Turtoi
Pages: 812-825
Published online: 16 May 2019
AbstractforTargets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6th antibody industrial symposium, June 25-26, 2018, Montpellier, France | Full Text | References | PDF (2 MB) | EPUB
  • 3109 Views
  • 5 CrossRef citations
  • 0Altmetric
Open Access

Report

Report
Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies
Michihiko Aoyama, Noritaka Hashii, Wataru Tsukimura, Kenji Osumi, Akira Harazono, Minoru Tada, Masato Kiyoshi, Akio Matsuda & Akiko Ishii-Watabe
Pages: 826-836
Published online: 08 May 2019
AbstractforEffects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 5164 Views
  • 43 CrossRef citations
  • 0Altmetric
Open Access
Report
Important roles of CD32 in promoting suppression of IL-4 induced immune responses by a novel anti-IL-4Rα therapeutic antibody
Jie Zhao, Liangfeng Jiang, Lan Deng, Wei Xu, Yang Cao, Chen Chen, Yan Yang, Huiling Wu, Yuping Huang, Zhenping Zhu & Haomin Huang
Pages: 837-847
Published online: 29 Apr 2019
AbstractforImportant roles of CD32 in promoting suppression of IL-4 induced immune responses by a novel anti-IL-4Rα therapeutic antibody | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 3377 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access
Report
Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis
Dilip K. Challa, Xiaoli Wang, Héctor Pérez Montoyo, Ramraj Velmurugan, Raimund J. Ober & E. Sally Ward
Pages: 848-860
Published online: 30 Apr 2019
AbstractforNeonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 4336 Views
  • 32 CrossRef citations
  • 0Altmetric
Open Access
Report
Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk
Nicoletta Bivi, Terry Moore, George Rodgers, Heather Denning, Travis Shockley, Craig A. Swearingen, Valentina Gelfanova, Boris Calderon, Daniel A. Peterson, Michael E. Hodsdon, Robert W. Siegel, Richard E. Higgs & Robert J. Konrad
Pages: 861-869
Published online: 17 May 2019
AbstractforInvestigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk | Full Text | References | PDF (3.6 MB) | EPUB
  • 4630 Views
  • 18 CrossRef citations
  • 0Altmetric
Open Access
Report
Antibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics
Michael A. Asensio, Yoong Wearn Lim, Nicholas Wayham, Kacy Stadtmiller, Robert C. Edgar, Jackson Leong, Renee Leong, Rena A. Mizrahi, Matthew S. Adams, Jan Fredrik Simons, Matthew J. Spindler, David S. Johnson & Adam S. Adler
Pages: 870-883
Published online: 21 Mar 2019
AbstractforAntibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 8948 Views
  • 25 CrossRef citations
  • 0Altmetric
Open Access
Report
A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing
Kothai Parthiban, Rajika L. Perera, Maheen Sattar, Yanchao Huang, Sophie Mayle, Edward Masters, Daniel Griffiths, Sachin Surade, Rachael Leah, Michael R. Dyson & John McCafferty
Pages: 884-898
Published online: 09 Jun 2019
AbstractforA comprehensive search of functional sequence space using large mammalian display libraries created by gene editing | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
  • 8348 Views
  • 33 CrossRef citations
  • 0Altmetric
Open Access
Report
Redirected optimized cell killing (ROCK®): A highly versatile multispecific fit-for-purpose antibody platform for engaging innate immunity
Kristina Ellwanger, Uwe Reusch, Ivica Fucek, Susanne Wingert, Thorsten Ross, Thomas Müller, Ute Schniegler-Mattox, Torsten Haneke, Erich Rajkovic, Joachim Koch, Martin Treder & Michael Tesar
Pages: 899-918
Published online: 07 Jun 2019
AbstractforRedirected optimized cell killing (ROCK®): A highly versatile multispecific fit-for-purpose antibody platform for engaging innate immunity | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
  • 10180 Views
  • 43 CrossRef citations
  • 0Altmetric
Open Access

Reports

Report
Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules
Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter & Roland E. Kontermann
Pages: 919-929
Published online: 03 May 2019
AbstractforDiabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 3399 Views
  • 19 CrossRef citations
  • 0Altmetric
Free Access

Report

Report
The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry
Richard A. Kerr, David A. Keire & Hongping Ye
Pages: 930-941
Published online: 15 Apr 2019
AbstractforThe impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 4202 Views
  • 14 CrossRef citations
  • 0Altmetric
Open Access
Report
An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
Shan Chung, Van Nguyen, Yuwen Linda Lin, Julien Lafrance-Vanasse, Suzie J. Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin Tesar, James A. Ernst, Saloumeh Fischer, Greg A. Lazar, Saileta Prabhu & An Song
Pages: 942-955
Published online: 29 Apr 2019
AbstractforAn in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 8035 Views
  • 42 CrossRef citations
  • 0Altmetric
Open Access
Report
Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5)
Jennifer Ahlberg, Craig Giragossian, Hua Li, Maria Myzithras, Ernie Raymond, Gary Caviness, Christine Grimaldi, Su-Ellen Brown, Rocio Perez, Danlin Yang, Rachel Kroe-Barrett, David Joseph, Chandrasena Pamulapati, Kelly Coble, Peter Ruus, Joseph R. Woska, Rajkumar Ganesan, Steven Hansel & M. Lamine Mbow
Pages: 956-964
Published online: 04 Jun 2019
AbstractforRetrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5) | Full Text | References | PDF (2.6 MB) | EPUB
  • 3412 Views
  • 6 CrossRef citations
  • 0Altmetric
Open Access
Report
Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics
Pao-Chun Lin, Kah Fai Chan, Irene A. Kiess, Joselyn Tan, Wahyu Shahreel, Sze-Yue Wong & Zhiwei Song
Pages: 965-976
Published online: 04 Jun 2019
AbstractforAttenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 9915 Views
  • 20 CrossRef citations
  • 0Altmetric
Open Access
Report
An anti-apoptotic HEK293 cell line provides a robust and high titer platform for transient protein expression in bioreactors
Tia A Arena, Bernice Chou, Peter D. Harms & Athena W. Wong
Pages: 977-986
Published online: 24 Apr 2019
AbstractforAn anti-apoptotic HEK293 cell line provides a robust and high titer platform for transient protein expression in bioreactors | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 5348 Views
  • 17 CrossRef citations
  • 0Altmetric
Free Access

Explore articles

Explore the most recently published articles

Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows
Tushar Jain et al.
Report | Published online: 31 Jul 2024
Open Access
Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay
Linlin Dong et al.
Brief Report | Published online: 30 Jul 2024
Open Access
Rapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo
Siva Charan Devanaboyina et al.
Report | Published online: 25 Jul 2024
Open Access
Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers
Bill Liao et al.
Report | Published online: 24 Jul 2024
Open Access