Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

Pavel V. Bondarenkoa Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USACorrespondence[email protected]

Andrew C. Nicholsa Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

Gang Xiaoa Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

Rachel Liuqing Shia Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

Pik Kay Chana Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

Thomas M Dillona Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

Fernando Garcesb Department of Therapeutics Discovery, Amgen Research, Amgen Inc, Thousand Oaks, CA, USA

David J. Semina Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

Margaret S. Riccia Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA

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