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mAbs Volume 14, 2022 - Issue 1
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Research Paper

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

Sarah C. Cowlesa Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;b Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAView further author information
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Allison Sheena Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;c Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAView further author information
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Luciano Santollania Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;b Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAView further author information
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Emi A. Lutza Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;c Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAView further author information
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Brianna M. Laxa Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;b Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAView further author information
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Joseph R. Palmeria Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;b Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USAView further author information
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Gordon J. Freemand Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USAView further author information
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K. Dane Wittrupa Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;b Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;c Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USACorrespondence[email protected]
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Article: 2088454 | Received 24 Mar 2022, Accepted 07 Jun 2022, Published online: 04 Aug 2022

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