Supplemental material
Forensic Sciences Research
Volume 4, 2019 - Issue 2
Reviews
Novel synthetic opioids – toxicological aspects and analysis
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Ângelo LuísCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Covilhã, Portugal; http://orcid.org/0000-0003-0712-6522View further author information
http://orcid.org/0000-0003-0712-6522View further author information, , Mário BarrosoServiço de Química e Toxicologia Forenses, Instituto Nacional de Medicina Legal e Ciências Forenses, Delegação do Sul, Lisboa, Portugal; http://orcid.org/0000-0001-8848-2734View further author information
http://orcid.org/0000-0001-8848-2734View further author information, , José RestolhoCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Covilhã, Portugal; ;nal von minden GmbH, Regensburg, GermanyCorrespondence[email protected]
http://orcid.org/0000-0002-2033-6746View further author information
http://orcid.org/0000-0002-2033-6746View further author information & Eugenia GallardoCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Covilhã, Portugal; ;Laboratório de Fármaco-Toxicologia - UBIMedical, Universidade da Beira Interior, Covilhã, Portugal; http://orcid.org/0000-0002-1802-8998View further author information
http://orcid.org/0000-0002-1802-8998View further author information show allRelated Research Data
Very sensitive and specific determination of sufentanil in human serum applying liquid chromatography–two stage mass spectrometry
Source:
Elsevier BV
Analysis of fentanyl analogs and novel synthetic opioids in blood, serum/plasma, and urine in forensic casework
Source:
Wiley
New and Emerging Illicit Psychoactive Substances
Source:
Elsevier BV
Qualitative Identification of Fentanyl Analogs and Other Opioids in Postmortem Cases by UHPLC-Ion Trap-MSn
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Oxford University Press (OUP)
Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class
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Informa UK Limited
Fatal Intoxication with Acetyl Fentanyl
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Wiley-Blackwell
Two cases of intoxication with new synthetic opioid, U-47700
Source:
Informa UK Limited
Lethal poisonings with AH-7921 in combination with other substances
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Elsevier BV
Development of a new multi-analyte assay for the simultaneous detection of opioids in serum and other body fluids using liquid chromatography–tandem mass spectrometry
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Elsevier BV
A case of U-47700 overdose with laboratory confirmation and metabolite identification
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Informa UK Limited
Newly Emerging Drugs of Abuse and Their Detection Methods: An ACLPS Critical Review.
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Oxford University Press (OUP)
Carfentanil in Impaired Driving Cases and the Importance of Drug Seizure Data
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Oxford University Press (OUP)
LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogues and Metabolites in Whole Blood at Sub ng mL –1 Concentrations
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American Chemical Society (ACS)
A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700)
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Elsevier BV
An Acute Acetyl Fentanyl Fatality: A Case Report With Postmortem Concentrations.
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Oxford University Press (OUP)
In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl
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American Association of Pharmaceutical Scientists (AAPS)
Identification and Quantification of Alpha-Methylfentanyl in Post Mortem Specimens
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Oxford University Press (OUP)
Acetylfentanyl: An Emerging Drug of Abuse
Source:
Elsevier BV
The Fentanyl Story
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Elsevier BV
Controversies and carfentanil: We have much to learn about the present state of opioid poisoning
Source:
Elsevier BV
Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street “Norco” in Central California: A Case Report
Source:
Elsevier BV
AH-7921: the list of new psychoactive opioids is expanded
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Springer Nature
The Pharmacokinetics and Pharmacodynamics of Carfentanil After Recreational Exposure: A Case Report
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Wiley
An Acute Butyr-Fentanyl Fatality: A Case Report with Postmortem Concentrations
Source:
Oxford University Press (OUP)
Analysis of Fentanyl and 18 Novel Fentanyl Analogs and Metabolites by LC–MS-MS, and report of Fatalities Associated with Methoxyacetylfentanyl and Cyclopropylfentanyl
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Oxford University Press (OUP)
LC–MS Determination of remifentanil in maternal and neonatal plasma
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Elsevier BV
Postmortem Toxicology Findings of Acetyl Fentanyl, Fentanyl, and Morphine in Heroin Fatalities in Tampa, Florida
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SAGE Publications
Detectability of fentanyl and designer fentanyls in urine by 3 commercial fentanyl immunoassays.
Source:
Wiley
Postmortem concentration distribution in fatal cases involving the synthetic opioid U-47700
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Springer Nature
Pharmacotoxicology of Non-fentanyl Derived New Synthetic Opioids
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Frontiers Media SA
Nuevas Drogas Psicoactivas
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Socidrogalcohol
Blood Levels of 3-Methylfentanyl in 3 Fatal Poisoning Cases
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Ovid Technologies (Wolters Kluwer Health)
U-47700: A Clinical Review of the Literature
Source:
Elsevier BV
Acetyl Fentanyl, a Novel Fentanyl Analog, Causes 14 Overdose Deaths in Rhode Island, March–May 2013
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Springer Science and Business Media LLC
Recreational use of carfentanil – a case report with laboratory confirmation
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Informa UK Limited
Metabolic characterization of AH-7921, a synthetic opioid designer drug:in vitrometabolic stability assessment and metabolite identification, evaluation ofin silicoprediction, andin vivoconfirmation
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Wiley-Blackwell
Identification of a new psychoactive substance in seized material: the synthetic opioidN-phenyl-N-[1-(2-phenethyl)piperidin-4-yl]prop-2-enamide (Acrylfentanyl)
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Wiley-Blackwell
Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry
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American Association of Pharmaceutical Scientists (AAPS)
Postmortem Determination of the Biological Distribution of Sufentanil and Midazolam after an Acute Intoxication
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ASTM International
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography–tandem mass spectrometry
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Elsevier BV
Novel synthetic opioids - toxicological aspects and analysis.
Source:
Taylor & Francis
Fatalities Involving Carfentanil and Furanyl Fentanyl: Two Case Reports
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Oxford University Press (OUP)
Opioids in the Frame of New Psychoactive Substances Network: A Complex Pharmacological and Toxicological Issue
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Bentham Science Publishers Ltd.
Intoxications involving acrylfentanyl and other novel designer fentanyls – results from the Swedish STRIDA project
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Informa UK Limited
Comparing fatal cases involving U-47700
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Springer Nature
Identification of Furanoylfentanil and its Metabolites in Human Urine
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OMICS Publishing Group
An autopsy case of acetyl fentanyl intoxication caused by insufflation of ‘designer drugs’
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Elsevier BV
Novel synthetic opioids – toxicological aspects and analysis
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Figshare
Postmortem Toxicology of New Synthetic Opioids
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Frontiers Media SA
Laboratory Testing for Prescription Opioids
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Springer Science and Business Media LLC
Determination of remifentanil in human blood by capillary gas chromatography with nitrogen-selective detection
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Elsevier BV
Time-dependent postmortem redistribution of butyrfentanyl and its metabolites in blood and alternative matrices in a case of butyrfentanyl intoxication
Source:
Elsevier BV
Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2013–2016: A Review
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Oxford University Press (OUP)
Intoxications involving the fentanyl analogs acetylfentanyl, 4-methoxybutyrfentanyl and furanylfentanyl: results from the Swedish STRIDA project
Source:
Informa UK Limited
A Fatality Involving AH-7921
Source:
Oxford University Press (OUP)
Analysis of 13 Fentanils, Including Sufentanil and Carfentanil, in Human Urine by Liquid Chromatography-Atmospheric-Pressure Ionization-Tandem Mass Spectrometry
Source:
Oxford University Press (OUP)
Identification of MT-45 Metabolites: In Silico Prediction, In Vitro Incubation with Rat Hepatocytes and In Vivo Confirmation
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Oxford University Press (OUP)
Observed Carfentanil Concentrations in 355 Blood Specimens from Forensic Investigations
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Oxford University Press (OUP)
Detection of Carfentanil by LC–MS-MS and Reports of Associated Fatalities in the USA
Source:
Oxford University Press (OUP)
Impact of Novel Psychoactive Substances on Clinical and Forensic Toxicology and Global Public Health
Source:
American Association for Clinical Chemistry (AACC)
The Bogus Drug: Three Methyl & Alpha Methyl Fentanyl Sold as “China White”
Source:
Informa UK Limited
New synthetic opioids in biological and non-biological matrices: A review of current analytical methods
Source:
Elsevier BV
Fatality Following Ingestion of Tetrahydrofuranylfentanyl, U-49900 and Methoxy-Phencyclidine
Source:
Oxford University Press (OUP)
Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N-(2-(diethylamino)cyclohexyl)-N-methylbenzamide (U-49900)
Source:
Springer Science and Business Media LLC
Ocfentanil overdose fatality in the recreational drug scene
Source:
Elsevier BV
MT-45, a new psychoactive substance associated with hearing loss and unconsciousness
Source:
Informa UK Limited
Anodyne by Design; Measuring the Prevalence of Esoteric Designer Opioids in Pain Management Patients
Source:
Oxford University Press (OUP)
An LC–MS-MS Method for the Analysis of Carfentanil, 3-Methylfentanyl, 2-Furanyl Fentanyl, Acetyl Fentanyl, Fentanyl and Norfentanyl in Postmortem and Impaired-Driving Cases
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Oxford University Press (OUP)
The analytical challenges of cyclopropylfentanyl and crotonylfentanyl: An approach for toxicological analysis
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Wiley
A fatal poisoning case by intravenous injection of “bath salts” containing acetyl fentanyl and 4-methoxy PV8
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Elsevier BV
Two Fatal Intoxications Involving Butyryl Fentanyl
Source:
Oxford University Press (OUP)
Novel Synthetic Opioids: The Pathologist’s Point of View
Source:
MDPI AG
The hidden web and the fentanyl problem: Detection of ocfentanil as an adulterant in heroin
Source:
Elsevier BV
Role of liquid chromatography–high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology
Source:
Informa UK Limited
Role of microextraction sampling procedures in forensic toxicology
Source:
Future Science, LTD
Quantitative determination of sufentanil in human plasma by liquid chromatography–tandem mass spectrometry
Source:
Elsevier BV
Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo
Source:
American Society for Clinical Investigation
U-47700: A Not So New Opioid
Source:
Oxford University Press (OUP)
Biogenic amines and the anti-nociceptive activity of agents with a non-opiate structure
Source:
Wiley-Blackwell
Three Cases of Fatal Acrylfentanyl Toxicity in the United States and a Review of Literature
Source:
Oxford University Press (OUP)
Fatal Intoxications Associated with the Designer Opioid AH-7921
Source:
Oxford University Press (OUP)
Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl
Source:
Oxford University Press (OUP)
Analysis of fentanyl and sufentanil in hair by GC/MS/MS
Source:
Springer Nature
Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse
Source:
Informa UK Limited
Determination of remifentanil in human heparinised whole blood by tandem mass spectrometry with short-column separation
Source:
Elsevier BV
The Chemical History of Morphine: An 8000-year Journey, from Resin to de-novo Synthesis
Source:
Elsevier BV
A Case Study Involving U-47700, Diclazepam and Flubromazepam—Application of Retrospective Analysis of HRMS Data
Source:
Oxford University Press (OUP)
The analysis of 132 novel psychoactive substances in human hair using a single step extraction by tandem LC/MS
Source:
Elsevier BV
Cross-Reactivity of Acetylfentanyl and Risperidone With a Fentanyl Immunoassay
Source:
Oxford University Press (OUP)
A Series of Deaths Involving Carfentanil in the UK and Associated Post-mortem Blood Concentrations
Source:
Oxford University Press (OUP)
Acute skin and hair symptoms followed by severe, delayed eye complications in subjects using the synthetic opioid MT-45
Source:
Wiley-Blackwell
A sensitive assay for the simultaneous measurement of alfentanil and fentanyl in plasma
Source:
Elsevier BV
Quantitative Measurement of Acetyl Fentanyl and Acetyl Norfentanyl in Human Urine by LC-MS/MS
Source:
American Chemical Society (ACS)
Activity-Based Concept to Screen Biological Matrices for Opiates and (Synthetic) Opioids
Source:
American Association for Clinical Chemistry (AACC)
Identification and quantification of mepirapim and acetyl fentanyl in authentic human whole blood and urine samples by GC–MS/MS and LC–MS/MS
Source:
Springer Nature
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