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OncoImmunology Volume 6, 2017 - Issue 3
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Original Research

JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

Chunwan LuDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA;Georgia Cancer Center, Augusta, GA, USA;Charlie Norwood VA Medical Center, Augusta, GA, USA
,
Asif TalukderDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA;Department of Surgery, Pathology, Medical College of Georgia, Augusta, GA, USA
,
Natasha M. SavagePathology, Medical College of Georgia, Augusta, GA, USA
,
Nagendra SinghDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA;Georgia Cancer Center, Augusta, GA, USA
&
Kebin LiuDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA;Georgia Cancer Center, Augusta, GA, USA;Charlie Norwood VA Medical Center, Augusta, GA, USACorrespondence[email protected]
Article: e1291106 | Received 17 Oct 2016, Accepted 31 Jan 2017, Published online: 30 Mar 2017

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