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Clinical
Using the ALSFRS-R in multicentre clinical trials for amyotrophic lateral sclerosis: potential limitations in current standard operating procedures
Jaap N.E. Bakers1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands;2 Centre of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Centre, University Medical Centre Utrecht, and De Hoogstraat Rehabilitation, Utrecht, the Netherlands;3 Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Centre, University Medical Centre Utrecht, the NetherlandsView further author information
, Adriaan D. de Jongh1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the NetherlandsView further author information
, Tommy M. Bunte1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the NetherlandsView further author information
, Lindsay Kendall4 Biostatistics, GlaxoSmithKline R&D, Stevenage, UKView further author information
, Steve S. Han5 Neurosciences, Takeda Pharmaceuticals, Cambridge, USAView further author information
, Noam Epstein6 Discovery Medicine, GlaxoSmithKline R&D, Upper Providence, USAView further author information
, Arseniy Lavrov7 Clinical Development, Novartis Gene Therapies, Cambridge, UK, andView further author information
, Anita Beelen2 Centre of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Centre, University Medical Centre Utrecht, and De Hoogstraat Rehabilitation, Utrecht, the Netherlands;3 Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Centre, University Medical Centre Utrecht, the NetherlandsView further author information
, Johanna M.A. Visser-Meily2 Centre of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Centre, University Medical Centre Utrecht, and De Hoogstraat Rehabilitation, Utrecht, the Netherlands;3 Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Centre, University Medical Centre Utrecht, the NetherlandsView further author information
, Leonard H. van den Berg1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the NetherlandsView further author information
& Ruben P. A. van Eijk1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands;8 Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the NetherlandsCorrespondence[email protected]
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Pages 500-507
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Received 31 Oct 2021, Accepted 05 Dec 2021, Published online: 24 Dec 2021
Related Research Data
Using the ALSFRS-R in multicentre clinical trials for amyotrophic lateral sclerosis: potential limitations in current standard operating procedures
Source:
Taylor & Francis
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