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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Coronaviruses

A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters

Bao-Zhong Zhanga CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of ChinaView further author information
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Xiaolei Wangb School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Shuofeng Yuanc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7996-1119View further author information
ORCID Icon,
Wenjun Lia CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of ChinaView further author information
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Ying Doub School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Vincent Kwok-Man Poond Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Chris Chung-Sing Chand Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Jian-Piao Caid Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Kenn KaHeng Chikd Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Kaiming Tangd Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Chris Chun-Yiu Chand Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Ye-Fan Hub School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Jing-Chu Hua CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of ChinaView further author information
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Smaranda Ruxandra Badeab School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Hua-Rui Gongb School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Xuansheng Linb School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaView further author information
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Hin Chuc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-2855-9837View further author information
ORCID Icon,
Xuechen Lie Department of Chemistry, Faculty of Science, The University of Hong Kong, Pokfulam, People's Republic of ChinaView further author information
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Kelvin Kai-Wang Toc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-1921-5824View further author information
ORCID Icon,
Li Liuc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;f AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, People’s Republic of ChinaView further author information
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Zhiwei Chenc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;f AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4511-2888View further author information
ORCID Icon,
Ivan Fan-Ngai Hungg Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-1556-2538View further author information
ORCID Icon,
Kwok Yung Yuenc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2083-1552View further author information
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Jasper Fuk-Woo Chanc State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of China;d Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6336-6657View further author information
ORCID Icon &
Jian-Dong Huanga CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China;b School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, People’s Republic of ChinaCorrespondence[email protected]
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Pages 874-884 | Received 04 Feb 2021, Accepted 20 Apr 2021, Published online: 09 May 2021

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