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Emerging Microbes & Infections
Volume 12, 2023 - Issue 2
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Coronaviruses
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
Jimena Pérez-Vargasa Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0002-4337-7903View further author information
Liam J. Worrallb Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0003-4966-7175View further author information
Andrea D. Olmsteada Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0002-1110-1291View further author information
Anh-Tien Tonc Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0001-7418-6563View further author information
Jaeyong Leeb Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, Canada;d Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, CanadaView further author information
, Ivan Villanuevaa Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0002-9325-731XView further author information
Connor A. H. Thompsona Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Svenja Dudeka Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Siobhan Ennise Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
https://orcid.org/0000-0002-0105-8269View further author information
Jason R. Smithc Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada;f Department of Chemistry, Simon Fraser University, Burnaby, Canada
https://orcid.org/0000-0001-7380-2192View further author information
Tirosh Shapiraa Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Joshua De Guzmana Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Shutong Ganga Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Fuqiang Banc Vancouver Prostate Centre, University of British Columbia, Vancouver, CanadaView further author information
, Marija Vuckovicb Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0002-0452-8270View further author information
Michael Bieleckif Department of Chemistry, Simon Fraser University, Burnaby, CanadaView further author information
, Suzana Kovacicf Department of Chemistry, Simon Fraser University, Burnaby, CanadaView further author information
, Calem Kenwardb Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0002-3771-0044View further author information
Christopher Yee Honga Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Danielle G. Gordona Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaView further author information
, Paul N. Levettg British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, Canada;h Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
https://orcid.org/0000-0001-6854-1776View further author information
Mel Krajdeng British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, Canada;h Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, CanadaView further author information
, Richard Leduci Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada
https://orcid.org/0000-0001-6854-8003View further author information
Pierre-Luc Boudreaulti Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada
https://orcid.org/0000-0002-2032-7970View further author information
Masahiro Niikurae Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
https://orcid.org/0000-0001-6611-8616View further author information
Mark Paetzeld Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada
https://orcid.org/0000-0002-7408-5487View further author information
Robert N. Youngf Department of Chemistry, Simon Fraser University, Burnaby, Canada
https://orcid.org/0000-0002-8235-6080View further author information
Artem Cherkasovc Vancouver Prostate Centre, University of British Columbia, Vancouver, CanadaCorrespondence[email protected]
https://orcid.org/0000-0002-1599-1439View further author information
Natalie C. J. Strynadkab Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, CanadaCorrespondence[email protected]
https://orcid.org/0000-0002-4058-9425View further author information
François Jeana Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, CanadaCorrespondence[email protected]
https://orcid.org/0000-0002-6148-7460View further author information
Article: 2246594
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Received 24 May 2023, Accepted 06 Aug 2023, Published online: 23 Aug 2023
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