In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

Siquan Shena Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Chengkang Tanga Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Weiwei Yanga Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Li Dinga Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Renru Hana Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Qingyu Shia Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Yan Guoa Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Dandan Yina Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaView further author information

Fupin Hua Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;b Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
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In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

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In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

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