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Epigenomics Volume 14, 2022 - Issue 18
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Research Article

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Saara Marttila1 Molecular Epidemiology, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;2 Gerontology Research Center, Tampere University, Tampere, 33014, FinlandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3071-3784View further author information
ORCID Icon,
Hely Tamminen1 Molecular Epidemiology, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, FinlandView further author information
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Sonja Rajić1 Molecular Epidemiology, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, FinlandView further author information
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Pashupati P Mishra3 Department of Clinical Chemistry, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;4 Finnish Cardiovascular Research Center Tampere, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;5 Fimlab Laboratories, Arvo Ylpön katu 4, Tampere, 33520, FinlandView further author information
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Terho Lehtimäki3 Department of Clinical Chemistry, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;4 Finnish Cardiovascular Research Center Tampere, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;5 Fimlab Laboratories, Arvo Ylpön katu 4, Tampere, 33520, FinlandView further author information
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Olli Raitakari6 Centre for Population Health Research, University of Turku & Turku University Hospital, Turku, 20014, Finland;7 Research Centre of Applied & Preventive Cardiovascular Medicine, University of Turku, Turku, 20014, Finland;8 Department of Clinical Physiology & Nuclear Medicine, Turku University Hospital, Turku, 20014, FinlandView further author information
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Mika Kähönen4 Finnish Cardiovascular Research Center Tampere, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;9 Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, FinlandView further author information
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Laura Kananen10 Faculty of Medicine & Health Technology, & Gerontology Research Center, Tampere University, Arvo Ylpön katu 34, Tampere, 33520,Finland;11 Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, 171 77, Sweden;12 Faculty of Social Sciences (Health Sciences), & Gerontology Research Center, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, FinlandView further author information
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Juulia Jylhävä11 Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, 171 77, Sweden;12 Faculty of Social Sciences (Health Sciences), & Gerontology Research Center, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, FinlandView further author information
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Sara Hägg11 Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, 171 77, SwedenView further author information
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Thomas Delerue13 Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, D-85764, GermanyView further author information
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Annette Peters14 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, D-85764, Germany;15 German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, GermanyView further author information
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Melanie Waldenberger13 Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, D-85764, Germany;15 German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, GermanyView further author information
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Marcus E Kleber16 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany;17 SYNLAB MVZ Humangenetik Mannheim, Mannheim, GermanyView further author information
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Winfried März16 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany;18 Competence Cluster for Nutrition & Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, 07743, Germany;19 SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Augsburg, 86156, Germany;20 Clinical Institute of Medical & Chemical Laboratory Diagnostics, Medical University of Graz, Graz, 8010, AustriaView further author information
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Riitta Luoto21 The Social Insurance Institute of Finland (Kela), Helsinki, 00250, Finland;22 The UKK Institute for Health Promotion Research, Kaupinpuistonkatu 1, Tampere, 33500, FinlandView further author information
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Jani Raitanen22 The UKK Institute for Health Promotion Research, Kaupinpuistonkatu 1, Tampere, 33500, Finland;23 Faculty of Social Sciences (Health Sciences), Tampere University, Arvo Ylpön katu 34, Tampere, 33520, FinlandView further author information
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Elina Sillanpää24 Gerontology Research Center & Faculty of Sport & Health Sciences, University of Jyväskylä, Jyväskylä, 40014, Finland;25 Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, 00014, FinlandView further author information
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Eija K Laakkonen24 Gerontology Research Center & Faculty of Sport & Health Sciences, University of Jyväskylä, Jyväskylä, 40014, FinlandView further author information
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Aino Heikkinen25 Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, 00014, FinlandView further author information
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Miina Ollikainen25 Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, 00014, FinlandView further author information
&
Emma Raitoharju1 Molecular Epidemiology, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland;4 Finnish Cardiovascular Research Center Tampere, Faculty of Medicine & Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, FinlandORCID Iconhttps://orcid.org/0000-0002-7023-8706View further author information
ORCID Icon show all
Pages 1105-1124 | Received 27 Jun 2022, Accepted 08 Sep 2022, Published online: 05 Oct 2022

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