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Original Articles: Research

Genetic alterations in glucocorticoid signaling pathway components are associated with adverse prognosis in children with relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia

Reinhard GrausenburgerChildren’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria,

Stephan BastelbergerChildren’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria,

Cornelia EckertDepartment of Pediatrics, Division of Oncology and Hematology, Charité, Berlin, Campus Virchow Klinikum, Berlin, Germany,

Maximilian KauerChildren’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria,

Martin StanullaDepartment of Pediatrics, University Hospital Hannover, Hannover, Germany,

Christian FrechChildren’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria,

Eva BauerLudwig Boltzmann Institute for Cancer Research, Vienna, Austria,

Dagmar StoiberLudwig Boltzmann Institute for Cancer Research, Vienna, Austria, ;Institute of Pharmacology, Medical University of Vienna, Vienna, Austria, and

Arend von StackelbergDepartment of Pediatrics, Division of Oncology and Hematology, Charité, Berlin, Campus Virchow Klinikum, Berlin, Germany,

Andishe AttarbaschiSt. Anna Kinderspital, Medical University Vienna, Vienna, Austria

Oskar A. HaasChildren’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria, ;St. Anna Kinderspital, Medical University Vienna, Vienna, Austria

Renate Panzer-GrümayerChildren’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria, Correspondence[email protected]

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Genetic alterations in glucocorticoid signaling pathway components are associated with adverse prognosis in children with relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia

ICMJE Forms for Disclosure of Potential Conflicts of Interest

Supplemental Methods. SNP array analysis, primers for NR3C1 sequencing.

Supplemental Table III. Association of recurrent gene deletions with clinical parameters.

Supplemental Table II. Overview of recurrent CNA of E/R-positive relapsed and PPR leukemias.

Supplemental Table I. Full listing of regions of CNA in 31 ETV6/RUNX1-positive relapse samples.

Supplemental Figure 4.

Supplemental Figure 3.

Supplemental Figure 2.

Supplemental Figure 1.

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Genetic alterations in glucocorticoid signaling pathway components are associated with adverse prognosis in children with relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia

ICMJE Forms for Disclosure of Potential Conflicts of Interest

Supplemental Methods. SNP array analysis, primers for NR3C1 sequencing.

Supplemental Table III. Association of recurrent gene deletions with clinical parameters.

Supplemental Table II. Overview of recurrent CNA of E/R-positive relapsed and PPR leukemias.

Supplemental Table I. Full listing of regions of CNA in 31 ETV6/RUNX1-positive relapse samples.

Supplemental Figure 4.

Supplemental Figure 3.

Supplemental Figure 2.

Supplemental Figure 1.

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