Supplemental material
Cell Cycle
Volume 13, 2014 - Issue 9
Related Research Data
An integrated approach for monitoring cell senescence.
Source:
Humana Press
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging.
Source:
Elsevier BV
Histone H2AX in DNA damage and repair.
Source:
Informa UK Limited
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Source:
Springer Science and Business Media LLC
Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the comet assay
Source:
Radiation Research Society
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Source:
Cell Press.
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
Source:
Cold Spring Harbor Laboratory
The E2F transcription factor is a cellular target for the RB protein.
Source:
Elsevier BV
Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy
Source:
Hindawi Limited
Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State
Source:
The Authors. Published by Elsevier Inc.
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
Source:
Springer Science and Business Media LLC
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Source:
Proceedings of the National Academy of Sciences
Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal Transdifferentiation
Source:
American Association for Cancer Research (AACR)
Autophagy mediates the mitotic senescence transition
Source:
Cold Spring Harbor Laboratory
Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells
Source:
Elsevier BV
The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis
Source:
Springer Science and Business Media LLC
The coordinate regulation of the p53 and mTOR pathways in cells.
Source:
Proceedings of the National Academy of Sciences
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
Source:
Springer Science and Business Media LLC
The advantages and disadvantages of being polyploid
Source:
Springer Science and Business Media LLC
mTOR regulation of autophagy
Source:
Wiley
Preliminary study of the homologous recombination repair pathway in mouse spermatogonial stem cells.
Source:
Wiley
Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response
Source:
Cold Spring Harbor Laboratory
Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance.
Source:
Wiley
mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging
Source:
Informa UK Limited
Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy.
Source:
Wiley
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS
Source:
Elsevier BV
Longevity-promoting agents enhance reprogramming
Source:
Wiley
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Source:
Springer Science and Business Media LLC
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.
Source:
Elsevier BV
Suppression of replicative senescence by rapamycin in rodent embryonic cells
Source:
Informa UK Limited
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.
Source:
Springer Science and Business Media LLC
High-intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
Source:
Elsevier BV
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Source:
Springer Science and Business Media LLC
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
Source:
American Society for Microbiology
Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.
Source:
Elsevier BV
Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer.
Source:
Bentham Science Publishers Ltd.
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
Source:
Elsevier BV
Chromatin modifications: The driving force of senescence and aging?
Source:
Impact Journals, LLC
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
Source:
Nature Publishing Group
Rapamycin decelerates cellular senescence
Source:
Informa UK Limited
Living on a break: cellular senescence as a DNA-damage response.
Source:
Springer Science and Business Media LLC
Global chromatin compaction limits the strength of the DNA damage response.
Source:
Rockefeller University Press
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.
Source:
Cold Spring Harbor Laboratory
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.
Source:
Springer Science and Business Media LLC
Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock.
Source:
Elsevier BV
Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells
Source:
Elsevier BV
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography.
Source:
Elsevier BV
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