Clinical Pharmacology: Advances and Applications, Volume 7, Issue (2015)

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Clinical Pharmacology: Advances and Applications, Volume 7, Issue (2015)

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Original Research

Article
Effects of food and alcohol on the pharmacokinetics of an oral, extended-release formulation of hydrocodone in healthy volunteers
Stephen J Farr, Cynthia Y Robinson & Christopher M Rubino
Pages: 1-9
Published online: 15 Dec 2022
AbstractforEffects of food and alcohol on the pharmacokinetics of an oral, extended-release formulation of hydrocodone in healthy volunteers | Full Text | References | PDF (339.9 KB)
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Open Access
Article
Bioavailability of everolimus administered as a single 5 mg tablet versus five 1 mg tablets: a randomized, open-label, two-way crossover study of healthy volunteers
Karen Thudium, Jorge Gallo, Emmanuel Bouillaud, Carolin Sachs, Simantini Eddy & Wing Cheung
Pages: 11-17
Published online: 22 Jan 2015
AbstractforBioavailability of everolimus administered as a single 5 mg tablet versus five 1 mg tablets: a randomized, open-label, two-way crossover study of healthy volunteers | Full Text | References | PDF (543 KB)
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Open Access
Article
Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study
Thomas Edrich, Gyorgy Frendl, Gregory Michaud & Ioannis Ch Paschalidis
Pages: 19-27
Published online: 05 Feb 2015
AbstractforHeparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study | Full Text | References | PDF (422.1 KB)
  • 56 Views
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Open Access
Article
Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers
Mihoko Kawabata, Yasuhiro Yokoyama, Takeshi Sasaki, Susumu Tao, Kensuke Ihara, Yasuhiro Shirai, Tetsuo Sasano, Masahiko Goya, Tetsushi Furukawa, Mitsuaki Isobe & Kenzo Hirao
Pages: 29-36
Published online: 16 Feb 2015
AbstractforSevere iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers | Full Text | References | PDF (934.5 KB)
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Open Access

Review

Review Article
Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function
David G Levitt & Michael D Levitt
Pages: 37-56
Published online: 26 Feb 2015
AbstractforCarbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function | Full Text | References | PDF (845.7 KB)
  • 149 Views
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Open Access
Review Article
Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways
Gaurab Chakrabarti, David E Gerber & David A Boothman
Pages: 57-68
Published online: 15 Dec 2022
AbstractforExpanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways | Full Text | References | PDF (993.4 KB)
  • 70 Views
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Open Access

Original Research

Article
Pharmacokinetic equivalence study of two formulations of the anticonvulsant pregabalin
Raymond R Tjandrawinata, Effi Setiawati, Ratih Sofia Ika Putri, Vincent Angga Gunawan, Fenny Ong, Liana W Susanto & Dwi Nofiarny
Pages: 69-75
Published online: 15 Dec 2022
AbstractforPharmacokinetic equivalence study of two formulations of the anticonvulsant pregabalin | Full Text | References | PDF (538.3 KB)
  • 227 Views
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Open Access

Letter

Letter
Pharmacodynamics and Pharmacokinetics of oral factor Xa inhibitors
Pontus B Persson
Pages: 77-78
Published online: 11 May 2015
CitationforPharmacodynamics and Pharmacokinetics of oral factor Xa inhibitors | Full Text | References | PDF (119.3 KB)
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Open Access

Original Research

Article
Pharmacokinetics and skin-tissue penetration of daptomycin in rats
Kazuaki Matsumoto, Masashi Kitaoka, Yuko Kuroda, Kazuro Ikawa, Norifumi Morikawa, Junichi Sasaki, Osamu Iketani, Satoshi Iwata, Tetsuya Horino, Seiji Hori & Junko Kizu
Pages: 79-82
Published online: 21 May 2015
AbstractforPharmacokinetics and skin-tissue penetration of daptomycin in rats | Full Text | References | PDF (210 KB)
  • 64 Views
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Open Access

Case Report

Case Report
Tizanidine-induced acute severe cystitis in a female taking famotidine
Resham Raj Poudel & Nisha Kusum Kafle
Pages: 83-85
Published online: 15 Dec 2022
AbstractforTizanidine-induced acute severe cystitis in a female taking famotidine | Full Text | References | PDF (186.3 KB)
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Open Access

Original Research

Article
An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614)
Lance A Wollenberg, Donald T Corson, Courtney A Nugent, Farran L Peterson, Ann M Ptaszynski, Alisha Arrigo, Coralee G Mannila, Kevin S Litwiler & Stacie J Bell
Pages: 87-95
Published online: 30 Sep 2015
AbstractforAn exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614) | Full Text | References | PDF (300.7 KB)
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Open Access
Article
Addition of a renin-angiotensin-aldosterone system inhibitor to a calcium channel blocker ameliorates arterial stiffness
Shunsuke Kiuchi, Shinji Hisatake, Muneyasu Kawasaki, Osamu Hirashima, Takayuki Kabuki, Junichi Yamazaki & Takanori Ikeda
Pages: 97-102
Published online: 08 Oct 2015
AbstractforAddition of a renin-angiotensin-aldosterone system inhibitor to a calcium channel blocker ameliorates arterial stiffness | Full Text | References | PDF (272.9 KB)
  • 53 Views
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Open Access
Article
A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males
Douglas S Kalman, Samantha Feldman, Adam Samson & Diane R Krieger
Pages: 103-109
Published online: 07 Oct 2015
AbstractforA clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males | Full Text | References | PDF (283.1 KB)
  • 250 Views
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Open Access
Article
NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines
William G North, Fuli Liu, Ruiyang Tian, Hamza Abbasi & Bonnie Akerman
Pages: 111-117
Published online: 23 Oct 2015
AbstractforNMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines | Full Text | References | PDF (725.7 KB)
  • 97 Views
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Open Access

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