Expert Opinion on Drug Discovery, Volume 14, Issue 12 (2019)

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Expert Opinion on Drug Discovery, Volume 14, Issue 12 (2019)

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Editorial

Editorial
Redirecting the revolution: new developments in drug development for psychiatry
Linda S. Brady, William Z. Potter & Joshua A. Gordon
Pages: 1213-1219
Published online: 23 Sep 2019
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Editorial
The current impact of water thermodynamics for small-molecule drug discovery
Stefan Geschwindner & Johan Ulander
Pages: 1221-1225
Published online: 10 Sep 2019
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Perspective

Article
4D- quantitative structure–activity relationship modeling: making a comeback
Denis Fourches & Jeremy Ash
Pages: 1227-1235
Published online: 12 Sep 2019
Abstractfor4D- quantitative structure–activity relationship modeling: making a comeback | Full Text | References | PDF (1.4 MB) | EPUB
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Review

Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy
Jay C. Groppe
Pages: 1237-1253
Published online: 12 Sep 2019
AbstractforInduced degradation of protein kinases by bifunctional small molecules: a next-generation strategy | Full Text | References | PDF (2 MB) | EPUB
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Open Access
PROTACs– a game-changing technology
Markella Konstantinidou, Jingyao Li, Bidong Zhang, Zefeng Wang, Shabnam Shaabani, Frans Ter Brake, Khaled Essa & Alexander Dömling
Pages: 1255-1268
Published online: 20 Sep 2019
AbstractforPROTACs– a game-changing technology | Full Text | References | PDF (1.9 MB) | EPUB
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Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings
Rafael Ferreira Dantas, Tereza Cristina Santos Evangelista, Bruno Junior Neves, Mario Roberto Senger, Carolina Horta Andrade, Sabrina Baptista Ferreira & Floriano Paes Silva-Junior
Pages: 1269-1282
Published online: 16 Aug 2019
AbstractforDealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Fragment-based screening with natural products for novel anti-parasitic disease drug discovery
Miaomiao Liu & Ronald J. Quinn
Pages: 1283-1295
Published online: 12 Sep 2019
AbstractforFragment-based screening with natural products for novel anti-parasitic disease drug discovery | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Open Access
Targeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs
Verònica Casadó-Anguera, Antoni Cortés, Vicent Casadó & Estefanía Moreno
Pages: 1297-1312
Published online: 11 Sep 2019
AbstractforTargeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs | Full Text | References | PDF (1.6 MB) | EPUB
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Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery
Adam J. Lucas, Joanne L. Sproston, Patrick Barton & Robert J. Riley
Pages: 1313-1327
Published online: 20 Sep 2019
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Correction

Correction
Correction
Page: 1328
Published online: 18 Sep 2019
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