Expert Opinion on Drug Discovery, Volume 18, Issue 12 (2023)

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Expert Opinion on Drug Discovery, Volume 18, Issue 12 (2023)

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Drug Discovery Case History

Article
Preclinical discovery and development of nirmatrelvir/ritonavir combinational therapy for the treatment of COVID-19 and the lessons learned from SARS-COV-2 variants
Pasquale Pagliano, Annamaria Spera, Carmine Sellitto, Giuliana Scarpati, Veronica Folliero, Ornella Piazza, Gianluigi Franci, Valeria Conti & Tiziana Ascione
Pages: 1301-1311
Published online: 23 Aug 2023
AbstractforPreclinical discovery and development of nirmatrelvir/ritonavir combinational therapy for the treatment of COVID-19 and the lessons learned from SARS-COV-2 variants | Full Text | References | PDF (2.8 MB) | EPUB
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Perspective

Integrating Liver-Chip data into pharmaceutical decision-making processes
Daniel Levner & Lorna Ewart
Pages: 1313-1320
Published online: 12 Sep 2023
AbstractforIntegrating Liver-Chip data into pharmaceutical decision-making processes | Full Text | References | PDF (2.3 MB) | EPUB
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Open Access
Applications of graphene-based nanomaterials in drug design: The good, the bad and the ugly
Zhengfeng Gao, Siyao Qin, Cécilia Ménard-Moyon & Alberto Bianco
Pages: 1321-1332
Published online: 04 Sep 2023
AbstractforApplications of graphene-based nanomaterials in drug design: The good, the bad and the ugly | Full Text | References | PDF (7.7 MB) | EPUB
  • 81 Views
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Review

Review Article
15 Years of molecular simulation of drug-binding kinetics
Chung F. Wong
Pages: 1333-1348
Published online: 01 Nov 2023
Abstractfor15 Years of molecular simulation of drug-binding kinetics | Full Text | References | PDF (1.1 MB) | EPUB
  • 180 Views
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Review Article
Advances in protein kinase drug discovery through targeting gatekeeper mutations
Jing Guo, Yang Zhou & Xiaoyun Lu
Pages: 1349-1366
Published online: 01 Nov 2023
AbstractforAdvances in protein kinase drug discovery through targeting gatekeeper mutations | Full Text | References | PDF (12.5 MB) | EPUB
  • 134 Views
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Review Article
Molecular simulations required to target novel and potent inhibitors of cancer invasion
Tian Lu, Tong Li, Meng-Ke Wu, Chi-Chong Zheng, Xue-Mei He, Hai-Liang Zhu, Li Li & Ruo-Jun Man
Pages: 1367-1377
Published online: 07 Sep 2023
AbstractforMolecular simulations required to target novel and potent inhibitors of cancer invasion | Full Text | References | PDF (577.2 KB) | EPUB
  • 106 Views
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Review Article
New frontiers in the design and discovery of therapeutics that target calcium ion signaling: a novel approach in the fight against cancer
Jyoti Singh, Abha Meena & Suaib Luqman
Pages: 1379-1392
Published online: 01 Sep 2023
AbstractforNew frontiers in the design and discovery of therapeutics that target calcium ion signaling: a novel approach in the fight against cancer | Full Text | References | PDF (2.9 MB) | EPUB
  • 113 Views
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Review Article
Tools and techniques for the discovery of therapeutic aptamers: recent advances
Lili Ai, Xinyi Jiang, Kejing Zhang, Cheng Cui, Bo Liu & Weihong Tan
Pages: 1393-1411
Published online: 01 Nov 2023
AbstractforTools and techniques for the discovery of therapeutic aptamers: recent advances | Full Text | References | PDF (10.5 MB) | EPUB
  • 255 Views
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Review Article
Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease
Juan D. Sánchez, Andrés R. Alcántara, Juan F. González & José María Sánchez-Montero
Pages: 1413-1428
Published online: 01 Nov 2023
AbstractforAdvances in the discovery of heterocyclic-based drugs against Alzheimer’s disease | Full Text | References | PDF (3.2 MB) | EPUB
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