Leukemia & Lymphoma, Volume 54, Issue 12 (2013)

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Leukemia & Lymphoma, Volume 54, Issue 12 (2013)

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Commentaries on selected articles in this issue

Article Commentary
High-risk diffuse large B-cell lymphoma: can we do better than rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone?
Anupkumar George, Constantine S. Tam & John F. Seymour
Pages: 2575-2576
Published online: 21 May 2013
CitationforHigh-risk diffuse large B-cell lymphoma: can we do better than rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone? | Full Text | References | PDF (547.2 KB) | Supplemental
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Commentary

Article Commentary
Dangling the carrot of improved survival in non-Hodgkin lymphoma: does carotenoid consumption make a difference?
Bridget Charbonneau
Pages: 2577-2578
Published online: 29 May 2013
CitationforDangling the carrot of improved survival in non-Hodgkin lymphoma: does carotenoid consumption make a difference? | Full Text | References | PDF (131.1 KB) | Supplemental
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Article Commentary
Haploidentical stem-cell transplant: the challenge of immune reconstitution
Avichai Shimoni
Pages: 2579-2580
Published online: 10 Jul 2013
CitationforHaploidentical stem-cell transplant: the challenge of immune reconstitution | Full Text | References | PDF (132.5 KB) | Supplemental
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Article Commentary
Uncoupling endoplasmic reticulum stress and autophagy: a potential implication for chronic lymphocytic leukemia therapy
Kumudha Balakrishnan & Varsha Gandhi
Pages: 2581-2583
Published online: 09 May 2013
First Page PreviewforUncoupling endoplasmic reticulum stress and autophagy: a potential implication for chronic lymphocytic leukemia therapy | Full Text | References | PDF (272.4 KB) | Supplemental
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Article Commentary
Searching the central nervous system for relapsed acute promyelocytic leukemia
Eytan M. Stein & Martin S. Tallman
Pages: 2584-2585
Published online: 12 May 2013
CitationforSearching the central nervous system for relapsed acute promyelocytic leukemia | Full Text | References | PDF (128.2 KB) | Supplemental
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Article Commentary
The use of 90yttrium-ibritumomab tiuxetan in patients on dialysis: what do we know regarding its pharmacokinetics?
Nelson Leung & Thomas E. Witzig
Pages: 2586-2587
Published online: 04 Jun 2013
CitationforThe use of 90yttrium-ibritumomab tiuxetan in patients on dialysis: what do we know regarding its pharmacokinetics? | Full Text | References | PDF (133 KB) | Supplemental
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Reviews

Review Article
The myelodysplastic syndromes: a personal recollection of four decades of classification and prognostic scoring systems
John M. Bennett
Pages: 2588-2591
Published online: 07 May 2013
AbstractforThe myelodysplastic syndromes: a personal recollection of four decades of classification and prognostic scoring systems | Full Text | References | PDF (235.8 KB) | Supplemental
  • 398 Views
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Review Article

Review Article
Acute lymphoblastic leukemia in adults: encouraging developments on the way to higher cure rates
Michael S. Mathisen, Hagop Kantarjian, Deborah Thomas, Susan O’Brien & Elias Jabbour
Pages: 2592-2600
Published online: 21 Jun 2013
AbstractforAcute lymphoblastic leukemia in adults: encouraging developments on the way to higher cure rates | Full Text | References | PDF (193.7 KB) | Supplemental
  • 1164 Views
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Review Article
Antileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
Herman van Besien, Antonella Sassano, Jessica K. Altman & Leonidas C. Platanias
Pages: 2601-2605
Published online: 29 Jul 2013
AbstractforAntileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors | Full Text | References | PDF (165.8 KB) | Supplemental
  • 308 Views
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Original Articles: Clinical

Article
Rituximab, cyclophosphamide-fractionated, vincristine, doxorubicin and dexamethasone alternating with rituximab, methotrexate and cytarabine overcomes risk features associated with inferior outcomes in treatment of newly diagnosed, high-risk diffuse large B-cell lymphoma
Anthony Mato, Tatyana Feldman, Tania Zielonka, Arun Singavi, Gabriella Gadaletta, Kathryn Waksmundzki, Pritish Bhattacharyya, Kar Fai Chow, Xiao Yang, David Panush, Harry Agress, Maria Rosario, Christina Howlett, Andrew Pecora & Andre Goy
Pages: 2606-2612
Published online: 15 May 2013
AbstractforRituximab, cyclophosphamide-fractionated, vincristine, doxorubicin and dexamethasone alternating with rituximab, methotrexate and cytarabine overcomes risk features associated with inferior outcomes in treatment of newly diagnosed, high-risk diffuse large B-cell lymphoma | Full Text | References | PDF (313.6 KB) | Supplemental
  • 510 Views
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Research Article

Article
Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma
Nicholas J. Ollberding, Briseis Aschebrook-Kilfoy, Donne Bennett D. Caces, Sonali M. Smith, Dennis D. Weisenburger & Brian C.-H. Chiu
Pages: 2613-2619
Published online: 30 Apr 2013
AbstractforDietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma | Full Text | References | PDF (693.6 KB) | Supplemental
  • 319 Views
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Article
High dose salvage therapy with dose intensive cyclophosphamide, etoposide and cisplatin may increase transplant rates for relapsed/refractory aggressive non-Hodgkin lymphoma
Archana Vijay, Qiuli Duan, Jan-Willem Henning, Peter Duggan, Andrew Daly, Mona Shafey, Nizar J. Bahlis & Douglas Allan Stewart
Pages: 2620-2626
Published online: 16 Apr 2013
AbstractforHigh dose salvage therapy with dose intensive cyclophosphamide, etoposide and cisplatin may increase transplant rates for relapsed/refractory aggressive non-Hodgkin lymphoma | Full Text | References | PDF (217.3 KB) | Supplemental
  • 320 Views
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Article
Phase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma
Danielle Brander, David Rizzieri, Jon Gockerman, Louis Diehl, Thomas Charles Shea, Carlos Decastro, Joseph O. Moore & Anne Beaven
Pages: 2627-2630
Published online: 19 Apr 2013
AbstractforPhase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma | Full Text | References | PDF (160.4 KB) | Supplemental
  • 185 Views
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Article
Clinical implications of positron emission tomography-negative residual computed tomography masses after chemotherapy for diffuse large B-cell lymphoma
Bouthaina S. Dabaja, Jack Phan, Osama Mawlawi, L. Jeffrey Medeiros, Carol Etzel, Fu-Wen Liang, Donald Podoloff, Yasuhiro Oki, Fredrick B. Hagemeister, Hubert Chuang, Luis E. Fayad, Jason Robert Westin, Ferial Shihadeh, Pamela K. Allen, Christine F. Wogan & Maria A. Rodriguez
Pages: 2631-2638
Published online: 07 May 2013
AbstractforClinical implications of positron emission tomography-negative residual computed tomography masses after chemotherapy for diffuse large B-cell lymphoma | Full Text | References | PDF (585.1 KB) | Supplemental
  • 422 Views
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Article
Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate
Velia D’Angelo, Maria Ramaglia, Adriana Iannotta, Matteo Francese, Elvira Pota, Maria Carmen Affinita, Giulia Pecoraro, Cristiana Indolfi, Martina Di Martino, Daniela Di Pinto, Salvatore Buffardi, Vincenzo Poggi, Paolo Indolfi & Fiorina Casale
Pages: 2639-2644
Published online: 19 Apr 2013
AbstractforInfluence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate | Full Text | References | PDF (199.9 KB) | Supplemental
  • 242 Views
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Article
Impact of occult bone marrow involvement on the outcome of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone therapy for diffuse large B-cell lymphoma
Hiroshi Arima, Hayato Maruoka, Koji Nasu, Sumie Tabata, Masayuki Kurata, Akiko Matsushita, Yukihiro Imai, Takayuki Takahashi & Takayuki Ishikawa
Pages: 2645-2653
Published online: 09 May 2013
AbstractforImpact of occult bone marrow involvement on the outcome of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone therapy for diffuse large B-cell lymphoma | Full Text | References | PDF (259.4 KB) | Supplemental
  • 239 Views
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Article
Patients with chronic lymphocytic leukemia with high-risk genomic features have inferior outcome on successive Cancer and Leukemia Group B trials with alemtuzumab consolidation: subgroup analysis from CALGB 19901 and CALGB 10101
Jeffrey A. Jones, Amy S. Ruppert, Weiqiang Zhao, Thomas S. Lin, Kanti Rai, Bercedis Peterson, Richard A. Larson, Guido Marcucci, Nyla A. Heerema & John C. Byrd
Pages: 2654-2659
Published online: 09 May 2013
AbstractforPatients with chronic lymphocytic leukemia with high-risk genomic features have inferior outcome on successive Cancer and Leukemia Group B trials with alemtuzumab consolidation: subgroup analysis from CALGB 19901 and CALGB 10101 | Full Text | References | PDF (332.9 KB) | Supplemental
  • 240 Views
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Article
Minimal residual disease after allogeneic stem cell transplant: a comparison among multiparametric flow cytometry, Wilms tumor 1 expression and chimerism status (Complete chimerism versus Low Level Mixed Chimerism) in acute leukemia
Giovanni Rossi, Angelo Michele Carella, Maria Marta Minervini, Lucia Savino, Andrea Fontana, Fabio Pellegrini, Michele Mario Greco, Emanuela Merla, Gianni Quarta, Giacomo Loseto, Silvana Capalbo, Gaetano Palumbo & Nicola Cascavilla
Pages: 2660-2666
Published online: 15 May 2013
AbstractforMinimal residual disease after allogeneic stem cell transplant: a comparison among multiparametric flow cytometry, Wilms tumor 1 expression and chimerism status (Complete chimerism versus Low Level Mixed Chimerism) in acute leukemia | Full Text | References | PDF (598.9 KB) | Supplemental
  • 611 Views
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Article
Significance of cytogenetic abnormalities in patients with polycythemia vera
Matjaz Sever, Alfonso Quintás-Cardama, Sherry Pierce, Lingsha Zhou, Hagop Kantarjian & Srdan Verstovsek
Pages: 2667-2670
Published online: 17 Apr 2013
AbstractforSignificance of cytogenetic abnormalities in patients with polycythemia vera | Full Text | References | PDF (156.4 KB) | Supplemental
  • 216 Views
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Article
Early lymphocyte recovery predicts superior overall survival after unmanipulated haploidentical blood and marrow transplant for myelodysplastic syndrome and acute myeloid leukemia evolving from myelodysplastic syndrome
Ying-Jun Chang, Xiang-Yu Zhao, Lan-Ping Xu, Dai-Hong Liu, Kai-Yan Liu, Yu-Hong Chen, Yu Wang, Xiao-Hui Zhang, Xiao-Su Zhao, Wei Han, Huan Chen, Feng-Rong Wang, Meng Lv & Xiao-Jun Huang
Pages: 2671-2677
Published online: 21 May 2013
AbstractforEarly lymphocyte recovery predicts superior overall survival after unmanipulated haploidentical blood and marrow transplant for myelodysplastic syndrome and acute myeloid leukemia evolving from myelodysplastic syndrome | Full Text | References | PDF (651.9 KB) | Supplemental
  • 341 Views
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Article
Circulating t(14;18)-positive cells in healthy individuals: association with age and sex but not with smoking
Carsten Hirt, Kerstin Weitmann, Frank Schüler, Thomas Kiefer, Charles S. Rabkin, Wolfgang Hoffmann & Gottfried Dölken
Pages: 2678-2684
Published online: 07 May 2013
AbstractforCirculating t(14;18)-positive cells in healthy individuals: association with age and sex but not with smoking | Full Text | References | PDF (476.7 KB) | Supplemental
  • 138 Views
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Original Articles: Research

Article
Identification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignancies
Emilia Mahoney, Kami Maddocks, Joseph Flynn, Jeffrey Jones, Sara L. Cole, Xiaoli Zhang, John C. Byrd & Amy J. Johnson
Pages: 2685-2692
Published online: 16 Apr 2013
AbstractforIdentification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignancies | Full Text | References | PDF (7.3 MB) | Supplemental
  • 491 Views
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Research Article

Article
Disruption of E627 and R683 interaction is responsible for B-cell acute lymphoblastic leukemia caused by JAK2 R683G(S) mutations
Qing-Yun Wu, Hua-Yan Guo, Feng Li, Zhen-Yu Li, Ling-Yu Zeng & Kai-Lin Xu
Pages: 2693-2700
Published online: 17 Apr 2013
AbstractforDisruption of E627 and R683 interaction is responsible for B-cell acute lymphoblastic leukemia caused by JAK2 R683G(S) mutations | Full Text | References | PDF (933 KB) | Supplemental
  • 331 Views
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Article
Dipeptidyl peptidase IV: serum activity and expression on lymphocytes in different hematological malignancies
Ivana Z. Matić, Milica Đorđević, Marija Đorđić, Nađa Grozdanić, Ana Damjanović, Branka Kolundžija, Ana Vidović, Jelena Bila, Slobodan Ristić, Biljana Mihaljević, Dragica Tomin, Nenad Milanović, Dušan Ristić, Mila Purić, Dušica Gavrilović, Oscar J. Cordero & Zorica D. Juranić
Pages: 2701-2706
Published online: 19 Apr 2013
AbstractforDipeptidyl peptidase IV: serum activity and expression on lymphocytes in different hematological malignancies | Full Text | References | PDF (332.2 KB) | Supplemental
  • 148 Views
  • 2 CrossRef citations
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Article
Up-regulation of tissue inhibitor of metalloproteinase-2 promotes SHI-1 cell invasion in nude mice
Chunling Wang, Xiaohui Cai, Baoan Chen, Zhengmei He, Zixing Chen, Jiannong Cen & Zhenjiang Li
Pages: 2707-2711
Published online: 19 Apr 2013
AbstractforUp-regulation of tissue inhibitor of metalloproteinase-2 promotes SHI-1 cell invasion in nude mice | Full Text | References | PDF (460.7 KB) | Supplemental
  • 100 Views
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Article
The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells
Hai-Jia Zhu, Ling Liu, Lei Fan, Li-Na Zhang, Cheng Fang, Zhi-Jian Zou, Jian-Yong Li & Wei Xu
Pages: 2712-2719
Published online: 30 Apr 2013
AbstractforThe BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells | Full Text | References | PDF (1 MB) | Supplemental
  • 254 Views
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Article
Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes
Begum Erdogan, Amma Bosompem, Dunfa Peng, Leng Han, Emily Smith, Mija E. Kennedy, Catherine E. Alford, Huiyun Wu, Zhongming Zhao, Claudio A. Mosse, Wael El-Rifai & Annette S. Kim
Pages: 2720-2727
Published online: 15 May 2013
AbstractforMethylation of promoters of microRNAs and their host genes in myelodysplastic syndromes | Full Text | References | PDF (432.8 KB) | Supplemental
  • 244 Views
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Letter to the Editor

Letter
Central nervous system relapse in acute promyelocytic leukemia: a single institution experience
Vinay Gupta, Wilson Gonsalves, Mrinal Patnaik & Naseema Gangat
Pages: 2728-2730
Published online: 16 Apr 2013
First Page PreviewforCentral nervous system relapse in acute promyelocytic leukemia: a single institution experience | Full Text | References | PDF (647.4 KB) | Supplemental
  • 164 Views
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Letter

Letter
Radioimmunotherapy with 90Y-ibritumomab tiuxetan for a hemodialysis patient with relapsed follicular lymphoma
Kenji Fukuno, Hisashi Tsurumi, Toshiki Yamada, Takayoshi Iida, Takeshi Takahashi & Hisataka Moriwaki
Pages: 2731-2733
Published online: 17 Apr 2013
First Page PreviewforRadioimmunotherapy with 90Y-ibritumomab tiuxetan for a hemodialysis patient with relapsed follicular lymphoma | Full Text | References | PDF (662.2 KB) | Supplemental
  • 103 Views
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Letter
Do matrix metalloproteinase-1 and glucose-6-phosphate dehydrogenase gene polymorphisms interact in promoting lymphoma development?
Maria G. Ennas, Mariagrazia Zucca, Giannina Satta, Tinucia Nonne, Emanuele Angelucci, Attilio Gabbas, Marco Rais, Aldo Scarpa & Pierluigi Cocco
Pages: 2734-2735
Published online: 17 Apr 2013
CitationforDo matrix metalloproteinase-1 and glucose-6-phosphate dehydrogenase gene polymorphisms interact in promoting lymphoma development? | Full Text | References | PDF (605.1 KB) | Supplemental
  • 58 Views
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Letter
Rituximab-induced acute thrombocytopenia: an underappreciated entity
Hazem El-Osta & Binu Nair
Pages: 2736-2737
Published online: 22 Apr 2013
CitationforRituximab-induced acute thrombocytopenia: an underappreciated entity | Full Text | References | PDF (592.5 KB) | Supplemental
  • 297 Views
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Letter
Pregnancy and multiple myeloma are not antinomic
Gabriel Brisou, Fadhela Bouafia-Sauvy, Lionel Karlin, Laure Lebras, Gilles Salles, Bertrand Coiffier & Anne-Sophie Michallet
Pages: 2738-2741
Published online: 30 Apr 2013
First Page PreviewforPregnancy and multiple myeloma are not antinomic | Full Text | References | PDF (634.5 KB) | Supplemental
  • 197 Views
  • 9 CrossRef citations
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Letter
The ETV6/RUNX1 fusion transcript is not detected in RNA isolated from neonatal dried blood spots from children later diagnosed with the corresponding leukemia
Gisela Barbany, Fredrika Gauffin, Ingegerd Öfverholm, Håkan Karlsson, Ingrid Thörn, Johan Arvidson, Mats Heyman, Britt Gustafsson & Ann Nordgren
Pages: 2742-2744
Published online: 17 Apr 2013
First Page PreviewforThe ETV6/RUNX1 fusion transcript is not detected in RNA isolated from neonatal dried blood spots from children later diagnosed with the corresponding leukemia | Full Text | References | PDF (688 KB) | Supplemental
  • 194 Views
  • 2 CrossRef citations
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Letter
Intravascular large B-cell lymphoma occurring 25 years after treatment of ALK-positive anaplastic large cell lymphoma
Penelope A. McKelvie, Christine Wools, Leslie Roberts & Mark Cook
Pages: 2745-2747
Published online: 30 Apr 2013
First Page PreviewforIntravascular large B-cell lymphoma occurring 25 years after treatment of ALK-positive anaplastic large cell lymphoma | Full Text | References | PDF (2.8 MB) | Supplemental
  • 112 Views
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Letter
Large vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia
Toru Kawakami, Toshiro Ito, Hitoshi Sakai, Nodoka Sekiguchi, Hideyuki Nakazawa, Noriko Senoo, Sayaka Nishina & Fumihiro Ishida
Pages: 2748-2749
Published online: 30 Apr 2013
CitationforLarge vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia | Full Text | References | PDF (841.4 KB) | Supplemental
  • 139 Views
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Letter
Donor lymphocyte infusion followed by pentostatin, cyclophosphamide and rituximab therapy is effective for relapsed chronic lymphocytic leukemia after allogeneic stem cell transplant
Mitsumasa Watanabe, Chishiho Nakamura, Sumie Fujii, Hitomi Kaneko, Hirokazu Hirata & Mitsuru Tsudo
Pages: 2750-2752
Published online: 30 Apr 2013
First Page PreviewforDonor lymphocyte infusion followed by pentostatin, cyclophosphamide and rituximab therapy is effective for relapsed chronic lymphocytic leukemia after allogeneic stem cell transplant | Full Text | References | PDF (1.6 MB) | Supplemental
  • 122 Views
  • 2 CrossRef citations
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Letter
Acute lymphoblastic leukemia developing during maintenance therapy with lenalidomide in a patient with multiple myeloma
Ricardo García-Muñoz, Diego Robles-de-Castro, Aura Muñoz-Rodríguez & Pilar Rabasa
Pages: 2753-2755
Published online: 15 Mar 2013
First Page PreviewforAcute lymphoblastic leukemia developing during maintenance therapy with lenalidomide in a patient with multiple myeloma | Full Text | References | PDF (546.4 KB) | Supplemental
  • 604 Views
  • 14 CrossRef citations
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Letter
Successful treatment of severe refractory hepatic graft-versus-host disease by cadaveric liver transplant
Amer M. Zeidan, Jocelyn L. Wozney, Michael Torbenson, Karen Krok & Javier Bolaños-Meade
Pages: 2756-2759
Published online: 30 Apr 2013
First Page PreviewforSuccessful treatment of severe refractory hepatic graft-versus-host disease by cadaveric liver transplant | Full Text | References | PDF (1,002.2 KB) | Supplemental
  • 184 Views
  • 4 CrossRef citations
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Letter
Deletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality
Yasuhiko Tsutsumi, Yoshiaki Chinen, Natsumi Sakamoto, Hisao Nagoshi, Kazuhiro Nishida, Satoru Kobayashi, Yuichi Yokokawa, Tomohiko Taki, Nana Sasaki, Mio Yamamoto-Sugitani, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Junya Kuroda & Masafumi Taniwaki
Pages: 2760-2764
Published online: 09 May 2013
First Page PreviewforDeletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality | Full Text | References | PDF (5.7 MB) | Supplemental
  • 606 Views
  • 13 CrossRef citations
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Letter
Thymoma with molecularly verified “conversion” to T lymphoblastic leukemia/lymphoma over 9 years
Vera Ertel, Martin Früh, Alexander Guenther, Thomas Cerny, Christian Fretz & Sergio Cogliatti
Pages: 2765-2768
Published online: 21 Jun 2013
First Page PreviewforThymoma with molecularly verified “conversion” to T lymphoblastic leukemia/lymphoma over 9 years | Full Text | References | PDF (3.2 MB) | Supplemental
  • 222 Views
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