Critical Reviews in Toxicology, Volume 44, Issue 1 (2014)

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Critical Reviews in Toxicology, Volume 44, Issue 1 (2014)

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Review Article

Review Article
Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study
J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed & James E. Klaunig
Pages: 1-49
Published online: 04 Nov 2013
AbstractforMode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study | Full Text | References | PDF (2.2 MB)
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Review Article
Dose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop
Melvin E. Andersen, R. Julian Preston, Andrew Maier, Alison M. Willis & Jacqueline Patterson
Pages: 50-63
Published online: 01 Oct 2013
AbstractforDose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop | Full Text | References | PDF (293.5 KB)
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Review Article
Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator
Clifford R. Elcombe, Richard C. Peffer, Douglas C. Wolf, Jason Bailey, Remi Bars, David Bell, Russell C. Cattley, Stephen S. Ferguson, David Geter, Amber Goetz, Jay I. Goodman, Susan Hester, Abigail Jacobs, Curtis J. Omiecinski, Rita Schoeny, Wen Xie & Brian G. Lake
Pages: 64-82
Published online: 04 Nov 2013
AbstractforMode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator | Full Text | References | PDF (516.8 KB)
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Review Article
Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study
R. A. Budinsky, D. Schrenk, T. Simon, M. Van den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker & J. C. Rowlands
Pages: 83-119
Published online: 19 Nov 2013
AbstractforMode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study | Full Text | References | PDF (2.1 MB) | Supplemental
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