Xenobiotica, Volume 39, Issue 2 (2009)

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Xenobiotica, Volume 39, Issue 2 (2009)

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Research Article

Article
Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design
E. S. Perloff, A. K. Mason, S. S. Dehal, A. P. Blanchard, L. Morgan, T. Ho, A. Dandeneau, R. M. Crocker, C. M. Chandler, N. Boily, C. L. Crespi & D. M. Stresser
Pages: 99-112
Published online: 01 Feb 2009
AbstractforValidation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design | Full Text | References | PDF (886.4 KB)
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Article
Pharmacokinetics and disposition of recombinant human osteoprotegerin (rhOPG) after intravenous administration in female fischer rats
Y. Miyaji, A. Kurihara, E. Kamiyama, T. Shiiki, K. Kawai & O. Okazaki
Pages: 113-124
Published online: 01 Feb 2009
AbstractforPharmacokinetics and disposition of recombinant human osteoprotegerin (rhOPG) after intravenous administration in female fischer rats | Full Text | References | PDF (959.5 KB)
  • 110 Views
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Article
Pharmacokinetics of recombinant human soluble thrombomodulin, thrombomodulin alfa in the rat
K. Tsuruta, T. Kodama, M. Serada, K. Hori, A. Inaba, T. Miyake & T. Kohira
Pages: 125-134
Published online: 01 Feb 2009
AbstractforPharmacokinetics of recombinant human soluble thrombomodulin, thrombomodulin alfa in the rat | Full Text | References | PDF (830.8 KB)
  • 95 Views
  • 7 CrossRef citations
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Article
Pharmacokinetic interaction between efavirenz and ketoconazole in rats
A. Saadeddin & J. E. Peris
Pages: 135-139
Published online: 01 Feb 2009
AbstractforPharmacokinetic interaction between efavirenz and ketoconazole in rats | Full Text | References | PDF (592.3 KB)
  • 177 Views
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Article
Functional characterization of CYP3A4.16: Catalytic activities toward midazolam and carbamazepine
K. Maekawa, T. Yoshimura, Y. Saito, Y. Fujimura, F. Aohara, C. Emoto, K. Iwasaki, N. Hanioka, S. Narimatsu, T. Niwa & J. Sawada
Pages: 140-147
Published online: 01 Feb 2009
AbstractforFunctional characterization of CYP3A4.16: Catalytic activities toward midazolam and carbamazepine | Full Text | References | PDF (697.5 KB)
  • 292 Views
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Article
In vitro and in vivo phase II metabolism of combretastatin A-4: Evidence for the formation of a sulphate conjugate metabolite
S. Aprile, E. Del Grosso & G. Grosa
Pages: 148-161
Published online: 01 Feb 2009
AbstractforIn vitro and in vivo phase II metabolism of combretastatin A-4: Evidence for the formation of a sulphate conjugate metabolite | Full Text | References | PDF (1.3 MB)
  • 268 Views
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Article
Effect of ursodeoxycholic acid on the pharmacokinetics of midazolam and CYP3A in the liver and intestine of rats
S. Kurosawa, S. Uchida, Y. Ito,S. Yamada
Pages: 162-170
Published online: 01 Feb 2009
AbstractforEffect of ursodeoxycholic acid on the pharmacokinetics of midazolam and CYP3A in the liver and intestine of rats | Full Text | References | PDF (671.8 KB)
  • 268 Views
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Article
Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human
M.-K. Choi, H. Kim, Y.-H. Han, I.-S. Song & C.-K. Shim
Pages: 171-181
Published online: 01 Feb 2009
AbstractforInvolvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human | Full Text | References | PDF (971.3 KB)
  • 306 Views
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Article
Role of hepatitis B virus X repression of C/EBPβ activity in the down-regulation of glutathione S-transferase A2 gene: implications in other phase II detoxifying enzyme expression
I. J. Cho, S. H. Ki, C. Brooks III & S. G. Kim
Pages: 182-192
Published online: 01 Feb 2009
AbstractforRole of hepatitis B virus X repression of C/EBPβ activity in the down-regulation of glutathione S-transferase A2 gene: implications in other phase II detoxifying enzyme expression | Full Text | References | PDF (968.7 KB)
  • 176 Views
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