Xenobiotica, Volume 39, Issue 9 (2009)

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Xenobiotica, Volume 39, Issue 9 (2009)

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Research Article

Article
Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling
C. R. Gibson, A. Bergman, P. Lu, F. Kesisoglou, W. S. Denney & E. Mulrooney
Pages: 637-648
Published online: 29 May 2009
AbstractforPrediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling | Full Text | References | PDF (1 MB)
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Article
Species differences for stereoselective metabolism of ethofumesate and its enantiomers in vitro
W. Zhu, Z. Dang, J. Qiu, Y. Liu, C. Lv, J. Diao & Z. Zhou
Pages: 649-655
Published online: 12 May 2009
AbstractforSpecies differences for stereoselective metabolism of ethofumesate and its enantiomers in vitro | Full Text | References | PDF (821.8 KB)
  • 154 Views
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Article
Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes
E. Floby, J. Johansson, J. Hoogstraate, N. J. Hewitt, J. Hill & A.-K. Sohlenius-Sternbeck
Pages: 656-662
Published online: 13 Jul 2009
AbstractforComparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes | Full Text | References | PDF (708.9 KB)
  • 360 Views
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Article
Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?
R. J. W. Meesters, M. Duisken & J. Hollender
Pages: 663-671
Published online: 29 May 2009
AbstractforCytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate? | Full Text | References | PDF (837.5 KB)
  • 300 Views
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Article
CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes
H.-X. Liu, Y. Hu, Y. Liu, Y.-Q. He, W. Li & L. Yang
Pages: 672-679
Published online: 01 Jul 2009
AbstractforCYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes | Full Text | References | PDF (989.1 KB)
  • 156 Views
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Article
Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation
S. K. Lee, M. J. Kang, C. Jin, M. K. In, D.-H. Kim & H. H. Yoo
Pages: 680-686
Published online: 24 Jun 2009
AbstractforFlavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation | Full Text | References | PDF (938.6 KB)
  • 176 Views
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Article
Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure
H. He, K.A. Lyons, X. Shen, Z. Yao, K. Bleasby, G. Chan, M. Hafey, X. Li, S. Xu, G. M. Salituro, L. H. Cohen & W. Tang
Pages: 687-693
Published online: 01 Jul 2009
AbstractforUtility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure | Full Text | References | PDF (735.4 KB)
  • 319 Views
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Article
Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers
Y. Han, D. Guo, Y. Chen, Z.-R. Tan & H.-H. Zhou
Pages: 694-699
Published online: 26 Jun 2009
AbstractforEffect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers | Full Text | References | PDF (727.9 KB)
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Article
Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species
E. F. Choo, J. P. Driscoll, J. Feng, B. Liederer, E. Plise, N. Randolph, Y. Shin, S. Wong & Y. Ran
Pages: 700-709
Published online: 20 May 2009
AbstractforDisposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species | Full Text | References | PDF (892.1 KB)
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