Xenobiotica, Volume 40, Issue 1 (2010)

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Xenobiotica, Volume 40, Issue 1 (2010)

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Research Article

Article
Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam
Y. Nishiya, K. Nakamura, N. Okudaira, K. Abe, N. Kobayashi & O. Okazaki
Pages: 1-8
Published online: 11 Nov 2009
AbstractforEffects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam | Full Text | References | PDF (849.2 KB)
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Article
Integrated HPLC-MS and 1H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides
C. H. Johnson, E. Karlsson, S. Sarda, L. Iddon, M. Iqbal, X. Meng, J. R. Harding, A. V. Stachulski, J. K. Nicholson, I. D. Wilson & J. C. Lindon
Pages: 9-23
Published online: 18 Nov 2009
AbstractforIntegrated HPLC-MS and 1H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides | Full Text | References | PDF (1 MB)
  • 314 Views
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Article
Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug–drug interaction to support regulatory submissions
P. Sharma, V. E. Holmes, R. Elsby, C. Lambert & D. Surry
Pages: 24-37
Published online: 17 Nov 2009
AbstractforValidation of cell-based OATP1B1 assays to assess drug transport and the potential for drug–drug interaction to support regulatory submissions | Full Text | References | PDF (838.4 KB)
  • 987 Views
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Article
CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes
Y.-F. Cao, Y.-Y. Zhang, J. Li, G.-B. Ge, D. Hu, H.-X. Liu, T. Huang, Y.-C. Wang, Z.-Z. Fang, D.-X. Sun, H. Huo, J. Yin & L. Yang
Pages: 38-47
Published online: 14 Dec 2009
AbstractforCYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes | Full Text | References | PDF (874.6 KB)
  • 218 Views
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Article
Identification of cinobufagin metabolites in the bile of rats
J. Ning, T.-H. Wu, Y. Tian, C.-Y. Wang, G. Tian, B.-J. Zhang, K.-X. Liu & X.-C. Ma
Pages: 48-54
Published online: 06 Nov 2009
AbstractforIdentification of cinobufagin metabolites in the bile of rats | Full Text | References | PDF (647 KB)
  • 117 Views
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Article
Pharmacokinetics of PSC 833 (valspodar) in its Cremophor EL formulation in rat
Z. Binkhathlan, D. A. Hamdy, D. R. Brocks & A. Lavasanifar
Pages: 55-61
Published online: 10 Nov 2009
AbstractforPharmacokinetics of PSC 833 (valspodar) in its Cremophor EL formulation in rat | Full Text | References | PDF (672.5 KB)
  • 249 Views
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Article
In vitro evidence for the formation of reactive intermediates of resveratrol in human liver microsomes
R. C. Steenwyk & B. Tan
Pages: 62-71
Published online: 02 Nov 2009
AbstractforIn vitro evidence for the formation of reactive intermediates of resveratrol in human liver microsomes | Full Text | References | PDF (1 MB)
  • 227 Views
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Article
In vitro mammalian metabolism of the mitosis inhibitor zoxamide and the relationship to its in vitro toxicity
F. Oesch, M. Metzler, E. Fabian, H. Kamp, T. Bernshausen, G. Damm, S. Triebel, J. Döhmer, R. Landsiedel & B. Van Ravenzwaay
Pages: 72-82
Published online: 14 Dec 2009
AbstractforIn vitro mammalian metabolism of the mitosis inhibitor zoxamide and the relationship to its in vitro toxicity | Full Text | References | PDF (855.7 KB)
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