Xenobiotica, Volume 41, Issue 7 (2011)

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Xenobiotica, Volume 41, Issue 7 (2011)

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General Xenobiochemistry

Article
The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes
Katharine Howe, Faizah Sanat, Alfred E. Thumser, Tanya Coleman & Nick Plant
Pages: 519-529
Published online: 09 Apr 2011
AbstractforThe statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes | Full Text | References | PDF (1,012.1 KB)
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Article
Assessment of UDP-glucuronosyltransferase catalyzed formation of Picroside II glucuronide in microsomes of different species and recombinant UGTs
Tingting Li, Yi Zheng, Feifei Fu, Hui Ji, Xijing Chen, Ying Zhao, Di Zhao, Ning Li & Lingli Zhang
Pages: 530-537
Published online: 27 Apr 2011
AbstractforAssessment of UDP-glucuronosyltransferase catalyzed formation of Picroside II glucuronide in microsomes of different species and recombinant UGTs | Full Text | References | PDF (769.2 KB)
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Article
Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin
Yazhi Wang, Heisio Ao, Zhengming Qian & Ying Zheng
Pages: 538-548
Published online: 11 May 2011
AbstractforIntestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin | Full Text | References | PDF (914.4 KB)
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Article
In vitro stability and metabolism of O2′, O3′, O5′-tri-acetyl-N6-(3-hydroxylaniline) adenosine in rat, dog and human plasma: Chemical hydrolysis and role of plasma esterases
Yin Liu, Jiuming He, Zeper Abliz & Haibo Zhu
Pages: 549-560
Published online: 13 Apr 2011
AbstractforIn vitro stability and metabolism of O2′, O3′, O5′-tri-acetyl-N6-(3-hydroxylaniline) adenosine in rat, dog and human plasma: Chemical hydrolysis and role of plasma esterases | Full Text | References | PDF (1,006 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Pharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration
J. Wang, Y. Xiao, Y. Lu, Z. Kang, M. Zhang, Y. Liu, J. Liang, M. Zhang & T. Li
Pages: 561-566
Published online: 29 Mar 2011
AbstractforPharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration | Full Text | References | PDF (627.2 KB)
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Animal Pharmacokinetics and Metabolism

Article
Rapid-onset sildenafil nasal spray carried by microemulsion systems: in vitro evaluation and in vivo pharmacokinetic studies in rabbits
Hsien-Tsung Lu, Ray-Neng Chen, Ming-Thau Sheu, Chung-Chiao Chang, Po-Yu Chou & Hsiu-O Ho
Pages: 567-577
Published online: 22 Mar 2011
AbstractforRapid-onset sildenafil nasal spray carried by microemulsion systems: in vitro evaluation and in vivo pharmacokinetic studies in rabbits | Full Text | References | PDF (883.3 KB)
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Article
Urinary excretion profiles of N-hydroxy-3,4-methylenedioxymethamphetamine in rats
Kenji Tsujikawa, Toshiyasu Mikuma, Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko T. Iwata & Hiroyuki Inoue
Pages: 578-584
Published online: 22 Mar 2011
AbstractforUrinary excretion profiles of N-hydroxy-3,4-methylenedioxymethamphetamine in rats | Full Text | References | PDF (769.1 KB)
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Article
Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats
Kamil Uney, Ilyas Tumer & Bünyamin Traş
Pages: 585-592
Published online: 09 Apr 2011
AbstractforMeasurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats | Full Text | References | PDF (728.8 KB)
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Molecular Toxicology

Article
Chan-Yu-Bao-Yuan-Tang induces apoptosis in NSCLC and SCLC cell lines via a mitochondria-mediated pathway
Yongkui Zhang, Fang Zeng, XiaoGuang Liu, YunCheng Li, JiHang Zhou, YanYan Huang, Yekai Wang, ShiQuan Zhou, WangYu Zhu, ErYun Shu, Guoer Zhou & Gang Chen
Pages: 593-602
Published online: 29 Mar 2011
AbstractforChan-Yu-Bao-Yuan-Tang induces apoptosis in NSCLC and SCLC cell lines via a mitochondria-mediated pathway | Full Text | References | PDF (1.3 MB)
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