Xenobiotica, Volume 42, Issue 3 (2012)

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Xenobiotica, Volume 42, Issue 3 (2012)

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General Xenobiochemistry

Article
Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans
Y. L. Song, W. H. Jing, H. Y. Zhao, R. Yan, P. T. Li & Y. T. Wang
Pages: 231-237
Published online: 29 Sep 2011
AbstractforStereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans | Full Text | References | PDF (1.4 MB)
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Article
Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2
Li-Ping Yang, Zhi-Wei Zhou, Xiao-Wu Chen, Chun Guang Li, Kevin B. Sneed, Jun Liang & Shu-Feng Zhou
Pages: 238-255
Published online: 04 Oct 2011
AbstractforComputational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2 | Full Text | References | PDF (1.6 MB)
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Article
Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: The role of free drug concentrations
Christoffer Bundgaard, Christina Sveigaard, Lise T. Brennum & Tine B. Stensbøl
Pages: 256-265
Published online: 21 Oct 2011
AbstractforAssociating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: The role of free drug concentrations | Full Text | References | PDF (727.5 KB)
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Article
Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues
Michael H. Court, Xiuling Zhang, Xinxin Ding, Karen K. Yee, Leah M. Hesse & Moshe Finel
Pages: 266-277
Published online: 13 Oct 2011
AbstractforQuantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues | Full Text | References | PDF (735 KB)
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Article
Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5
Kyung-Ah Seo, So-Jeong Lee, Kwon-Bok Kim, Soo Kyung Bae, Kwang-Hyeon Liu, Dong-Hyun Kim & Jae-Gook Shin
Pages: 278-284
Published online: 24 Oct 2011
AbstractforIlaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5 | Full Text | References | PDF (716.3 KB) | Supplemental
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Article
Microbial production of phase I and phase II metabolites of midazolam
Cyrille Marvalin, Mireille Denoux, Serge Pérard, Sébastien Roy & Robert Azerad
Pages: 285-293
Published online: 24 Oct 2011
AbstractforMicrobial production of phase I and phase II metabolites of midazolam | Full Text | References | PDF (952.7 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae
Guang Hu, Shiu On Siu, Shang Li, Ivan Keung Chu, Yiu Wa Kwan, Shun Wan Chan, George Pak-Heng Leung, Ru Yan & Simon Ming-Yuen Lee
Pages: 294-303
Published online: 02 Oct 2011
AbstractforMetabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Bioavailability and pharmacokinetics of S-propargyl-L-cysteine, a novel cardioprotective agent, after single and multiple doses in Beagle dogs
Yuanting Zheng, Jialin Xu, Guo Ma, Jinlian Zhang, Qing Zhu, Hongrui Liu, Peng Zhang, Yizhun Zhu & Weimin Cai
Pages: 304-309
Published online: 01 Oct 2011
AbstractforBioavailability and pharmacokinetics of S-propargyl-L-cysteine, a novel cardioprotective agent, after single and multiple doses in Beagle dogs | Full Text | References | PDF (722.6 KB)
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Article
ϵ-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation
U. Lee, Y.H. Choi, Y.G. Kim, B.K. Lee, E. Oh & M.G. Lee
Pages: 310-315
Published online: 12 Oct 2011
Abstractforϵ-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation | Full Text | References | PDF (653.8 KB)
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