Xenobiotica, Volume 43, Issue 4 (2013)

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Xenobiotica, Volume 43, Issue 4 (2013)

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General Xenobiochemistry

Article
Cytochrome P450 2A isoenzymes in freshly prepared blood lymphocytes isolated from rats and validation as a biomarker for clinical studies in humans
Amit Sharma, Konka Dinesh, Sanjay Yadav, Swatantra K. Jain, Mohan C. Pant & Devendra Parmar
Pages: 311-319
Published online: 31 Aug 2012
AbstractforCytochrome P450 2A isoenzymes in freshly prepared blood lymphocytes isolated from rats and validation as a biomarker for clinical studies in humans | Full Text | References | PDF (720.4 KB)
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Article
Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy
Brigitte Gerin, Sylvie Dell’Aiera, Lysiane Richert, Steven Smith & Hugues Chanteux
Pages: 320-335
Published online: 15 Nov 2012
AbstractforAssessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy | Full Text | References | PDF (1.8 MB)
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Article
Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches
Chitra Sridar, Imad Hanna & Paul F. Hollenberg
Pages: 336-345
Published online: 03 Sep 2012
AbstractforQuantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches | Full Text | References | PDF (772.5 KB)
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Article
Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetone in vitro
Lucie Skarydova, Milan Nobilis & Vladimir Wsól
Pages: 346-354
Published online: 28 Sep 2012
AbstractforRole of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetone in vitro | Full Text | References | PDF (795.2 KB)
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Article
Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug
Hyo-Eon Jin, Boran Song, Sang-Bum Kim, Won-Sik Shim, Dae-Duk Kim, Saeho Chong, Suk-Jae Chung & Chang-Koo Shim
Pages: 355-367
Published online: 28 Sep 2012
AbstractforTransport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug | Full Text | References | PDF (836.2 KB)
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Article
In vitro metabolism of the 5-hydroxytryptamine1B receptor antagonist elzasonan
Amin Kamel, Kevin Colizza & R. Scott Obach
Pages: 368-378
Published online: 03 Oct 2012
AbstractforIn vitro metabolism of the 5-hydroxytryptamine1B receptor antagonist elzasonan | Full Text | References | PDF (1.1 MB)
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Clinical Pharmacokinetics and Metabolism

Article
A phase I, open-label, single-dose, mass balance study of 14C-labeled abiraterone acetate in healthy male subjects
Milin Acharya, Martha Gonzalez, Geert Mannens, Ronald De Vries, Christian Lopez, Thomas Griffin & NamPhuong Tran
Pages: 379-389
Published online: 28 Sep 2012
AbstractforA phase I, open-label, single-dose, mass balance study of 14C-labeled abiraterone acetate in healthy male subjects | Full Text | References | PDF (788.8 KB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite
Austin C. Li, James P. Chovan, Erya Yu & Ismael Zamora
Pages: 390-398
Published online: 30 Aug 2012
AbstractforUpdate on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite | Full Text | References | PDF (1.3 MB)
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