Xenobiotica, Volume 43, Issue 7 (2013)

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Xenobiotica, Volume 43, Issue 7 (2013)

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General Xenobiochemistry

Article
CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats
Scott A. Reisman, Keith W. Ward, Curtis D. Klaassen & Colin J. Meyer
Pages: 571-578
Published online: 17 Dec 2012
AbstractforCDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats | Full Text | References | PDF (583.2 KB)
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Research Article

Article
The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin
Ji-Eon Kim, Hyun-Jong Cho, Jung Sun Kim, Chang-Koo Shim, Suk-Jae Chung, Min-Ho Oak, In-Soo Yoon & Dae-Duk Kim
Pages: 579-591
Published online: 19 Dec 2012
AbstractforThe limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin | Full Text | References | PDF (329.8 KB)
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Article
A simplified approach to predict CYP3A-mediated drug–drug interactions at early drug discovery: validation with clinical data
Nathalie Rioux, Joëlle Batonga, Federico Colombo, Jonathan Massé, Christine Zouki, Maria D. Ribadeneira, Jianmin Duan & Richard C. Bethell
Pages: 592-597
Published online: 17 Dec 2012
AbstractforA simplified approach to predict CYP3A-mediated drug–drug interactions at early drug discovery: validation with clinical data | Full Text | References | PDF (222.1 KB)
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Article
Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam
J. Kuze, T. Mutoh, T. Takenaka, N. Oda, N. Hanioka & S. Narimatsu
Pages: 598-606
Published online: 03 Jan 2013
AbstractforEvaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam | Full Text | References | PDF (669.1 KB)
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Article
Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human
Tjerk Bueters, Sanja Juric, Anna-Karin Sohlenius-Sternbeck, Yin Hu & Johan Bylund
Pages: 607-616
Published online: 02 Jan 2013
AbstractforRat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human | Full Text | References | PDF (514.2 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate
Xiaochun Zhu, J. Greg Slatter, Maurice G. Emery, Molly R. Deane, Anna Akrami, Xiping Zhang, Dean Hickman, Gary L. Skiles & Raju Subramanian
Pages: 617-627
Published online: 17 Dec 2012
AbstractforActivity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate | Full Text | References | PDF (630.1 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry
Zhigang Sui, Na Li, Zhiqiang Liu, Jun Yan & Zhongying Liu
Pages: 628-635
Published online: 26 Dec 2012
AbstractforMetabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry | Full Text | References | PDF (463.4 KB)
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Pharmacogenetics

Article
Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine
Chang-Ik Choi, Jung-Woo Bae, Seul-Ki Keum, Yun-Jeong Lee, Hye-In Lee, Choon-Gon Jang & Seok-Yong Lee
Pages: 636-640
Published online: 19 Dec 2012
AbstractforEffects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine | Full Text | References | PDF (133.9 KB)
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Research Article

Article
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism
Shripad D. Chitnis, Ken Ogasawara, Björn Schniedewind, Reginald Y. Gohh, Uwe Christians & Fatemeh Akhlaghi
Pages: 641-649
Published online: 02 Jan 2013
AbstractforConcentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism | Full Text | References | PDF (459.3 KB)
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