Xenobiotica, Volume 44, Issue 11 (2014)

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Xenobiotica, Volume 44, Issue 11 (2014)

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Topics in Xenobiochemistry

Article Commentary
Ethyl sulphate, a chemically reactive human metabolite of ethanol?
Stephen C. Mitchell, Rosemary H. Waring & Ian D. Wilson
Pages: 957-960
Published online: 18 Jul 2014
AbstractforEthyl sulphate, a chemically reactive human metabolite of ethanol? | Full Text | References | PDF (111.6 KB)
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General Xenobiochemistry

Article
Experimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species
Thomas R. B. Grandjean, Mike J. Chappell, Alex M. Lench, James W. T. Yates & Charles J. O’Donnell
Pages: 961-974
Published online: 16 Jul 2014
AbstractforExperimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species | Full Text | References | PDF (942.2 KB)
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Research Article

Article
Development of a pharmacokinetic/pharmacodynamic/disease progression model in NC/Nga mice for development of novel anti-atopic dermatitis drugs
In-Hwan Baek, Byung-Yo Lee, Jung-Woo Chae, Gyu Yong Song, Wonku Kang & Kwang-Il Kwon
Pages: 975-987
Published online: 30 May 2014
AbstractforDevelopment of a pharmacokinetic/pharmacodynamic/disease progression model in NC/Nga mice for development of novel anti-atopic dermatitis drugs | Full Text | References | PDF (1.1 MB)
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Article
In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences
Dongxue Sun, Liangliang Zhu, Ling Xiao, Yangliu Xia, Guangbo Ge, Yunfeng Cao, Yan Wu, Jun Yin & Ling Yang
Pages: 988-995
Published online: 11 Jun 2014
AbstractforIn vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences | Full Text | References | PDF (471.6 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats
Takahiro Murai, Hideo Takakusa, Daisuke Nakai, Emi Kamiyama, Tomoe Taira, Tomoko Kimura, Takeshi Jimbo, Mohinder Bathala, Fraser Pickersgill, Hamim Zahir, Taro Tokui, Ronald E. Savage, Mark A. Ashwell & Takashi Izumi
Pages: 996-1008
Published online: 09 Jun 2014
AbstractforMetabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats | Full Text | References | PDF (611.1 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetic interaction of entinostat and lapatinib following single and co-oral administration in rats
Xuezhi Yang, Qingwei Zhang, Mengchun Chen & Lufeng Hu
Pages: 1009-1013
Published online: 16 May 2014
AbstractforPharmacokinetic interaction of entinostat and lapatinib following single and co-oral administration in rats | Full Text | References | PDF (447.1 KB)
  • 335 Views
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Research Article

Article
Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats
Linzhi Chen, Roger St. George, Stephen H. Norris, Yanping Mao, Elsy Philip, Li-Quan Wang, Diana Wu & Michael J. Potchoiba
Pages: 1014-1025
Published online: 15 May 2014
AbstractforBiotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats | Full Text | References | PDF (707.4 KB)
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Article
Absorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats
Ryoko Sawamura, Miho Kazui, Atsushi Kurihara & Takashi Izumi
Pages: 1026-1038
Published online: 11 Jun 2014
AbstractforAbsorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats | Full Text | References | PDF (1.6 MB)
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Xenobiotic Transporters

Article
Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (−/−) rats into absorption study of multiple transporter substrate
Motoya Suzuki, Hiroshi Komura, Tomonori Yoshikawa, Seiji Enya, Akemi Nagao, Hiroaki Takubo & Motohiro Kogayu
Pages: 1039-1045
Published online: 19 May 2014
AbstractforCharacterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (−/−) rats into absorption study of multiple transporter substrate | Full Text | References | PDF (517.5 KB)
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Research Article

Article
The xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood–brain barrier of rats
Sabrina Nickel & Anne Mahringer
Pages: 1046-1054
Published online: 19 Jun 2014
AbstractforThe xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood–brain barrier of rats | Full Text | References | PDF (576.5 KB)
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