Xenobiotica, Volume 45, Issue 12 (2015)

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Xenobiotica, Volume 45, Issue 12 (2015)

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General Xenobiochemistry

Article
Mechanism-based inactivation of CYP2C9 by linderane
Hui Wang, Kai Wang, Xu Mao, Qingqing Zhang, Tong Yao, Ying Peng & Jiang Zheng
Pages: 1037-1046
Published online: 11 Jun 2015
AbstractforMechanism-based inactivation of CYP2C9 by linderane | Full Text | References | PDF (872 KB)
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Article
S-carboxymethyl-l-cysteine and it (R/S)-S-oxides in beagle dog plasma and hepatic cytosol
Panayotis Panagopoulos, Stephen C. Mitchell & Glyn B. Steventon
Pages: 1047-1053
Published online: 11 Jun 2015
AbstractforS-carboxymethyl-l-cysteine and it (R/S)-S-oxides in beagle dog plasma and hepatic cytosol | Full Text | References | PDF (171.2 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Disposition, metabolism and mass balance of delafloxacin in healthy human volunteers following intravenous administration
Andrew McEwen, Laura Lawrence, Randy Hoover, Lloyd Stevens, Stuart Mair, Gill Ford, Dylan Williams & Stuart Wood
Pages: 1054-1062
Published online: 19 May 2015
AbstractforDisposition, metabolism and mass balance of delafloxacin in healthy human volunteers following intravenous administration | Full Text | References | PDF (503.1 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys
Shin-Ichi Inaba, Tomoko Ikeda, Maki Goto, Hisako Tanaka, Makoto Takahashi, Haruo Iwabuchi & Takashi Izumi
Pages: 1063-1080
Published online: 18 Jun 2015
AbstractforPharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Utilizing 19F NMR to investigate drug disposition early in drug discovery
Haitao Hu, Naijia Huang, Ping Yi, Yu-Hua Hui, Robert D. Dally, William J. Ehlhardt & Palaniappan Kulanthaivel
Pages: 1081-1091
Published online: 06 May 2015
AbstractforUtilizing 19F NMR to investigate drug disposition early in drug discovery | Full Text | References | PDF (898.9 KB) | Supplemental
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Article
Pharmacokinetic properties of trifolirhizin, (–)-maackiain, (–)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats
Soo Min Jang, Soo Hyeon Bae, Woong-Kee Choi, Jung Bae Park, Doyun Kim, Jee Sun Min, Hunseung Yoo, Minseok Kang, Keun Ho Ryu & Soo Kyung Bae
Pages: 1092-1104
Published online: 11 Jun 2015
AbstractforPharmacokinetic properties of trifolirhizin, (–)-maackiain, (–)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats | Full Text | References | PDF (1.1 MB)
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Article
Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent
Masatoshi Hasegawa, Yukihiro Chino, Nobuko Horiuchi, Kenji Hachiuma, Masahiro Ishida, Yoshiki Fukasawa, Yasuhiro Nakai & Jun-ichi Yamaguchi
Pages: 1105-1115
Published online: 06 Jul 2015
AbstractforPreclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent | Full Text | References | PDF (949.4 KB)
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Article
Effect of glycyrrhizic acid on rhein renal penetration: a microdialysis study in rats
Yinghui Wei, Jiani Guan, Xiaoqiong Ma, Yicong Zhong, Jianping Ma & Fanzhu Li
Pages: 1116-1121
Published online: 04 Jun 2015
AbstractforEffect of glycyrrhizic acid on rhein renal penetration: a microdialysis study in rats | Full Text | References | PDF (272.5 KB) | Supplemental
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Article
Effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of clopidogrel in rats
Feng Chen, Yu Yang, Chunxue Fang, Jincheng Zhao, Mei Han, Qiushuang Zhu, Xue Bai, Mingyuan Liu & Guangyuan Yang
Pages: 1122-1128
Published online: 11 Jun 2015
AbstractforEffect of fluvoxamine on the pharmacokinetics and pharmacodynamics of clopidogrel in rats | Full Text | References | PDF (314.3 KB)
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Xenobiotic Transporters

Article
Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR
Francesca Toselli, Isabelle de Waziers, Mary Dutheil, Marc Vincent, Peter A. Wilce, Peter R. Dodd, Philippe Beaune, Marie-Anne Loriot & Elizabeth M. J. Gillam
Pages: 1129-1137
Published online: 22 Jun 2015
AbstractforGene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR | Full Text | References | PDF (839.5 KB) | Supplemental
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Article
Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine
Chen Chen, Zhi-Tao Wu, Lei-Lei Ma, Xuan Ni, Yun-Fei Lin, Le Wang, Ke-Ping Chen, Cheng-gang Huang & Guoyu Pan
Pages: 1138-1146
Published online: 11 Jun 2015
AbstractforOrganic anion-transporting polypeptides contribute to the hepatic uptake of berberine | Full Text | References | PDF (912.4 KB)
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Pharmacogenetics

Article
Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis
Takenori Niioka, Atsushi Komatsuda, Shotaro Kato, Masaru Togashi, Shin Okuyama, Ayumi Omokawa, Mizuho Nara, Hideki Wakui, Naoto Takahashi & Masatomo Miura
Pages: 1147-1153
Published online: 20 Jul 2015
AbstractforEffects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis | Full Text | References | PDF (311.2 KB)
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Editorial Board

Editorial Board
Page: ebi
Published online: 22 Oct 2015
CitationforEditorial Board | Full Text | PDF (24.8 KB)
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