Xenobiotica, Volume 47, Issue 5 (2017)

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Xenobiotica, Volume 47, Issue 5 (2017)

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General Xenobiochemistry

Article
Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound
Feng Li, Shuai Wang, Danyi Lu, Yifei Wang, Dong Dong & Baojian Wu
Pages: 369-375
Published online: 17 Jun 2016
AbstractforIdentification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound | Full Text | References | PDF (996.1 KB)
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Article
The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A
Xin Liu, Yun-Feng Cao, Pei-Pei Dong, Liang-Liang Zhu, Zhenying Zhao, Xue Wu, Zhi-Wei Fu, Chun-Ting Huang, Zhong-Ze Fang & Hong-Zhi Sun
Pages: 376-381
Published online: 30 Jun 2016
AbstractforThe inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A | Full Text | References | PDF (827.9 KB)
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Article
Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling
Hidetaka Kamimura, Satoshi Ito, Hiroyuki Chijiwa, Takeshi Okuzono, Tomohiro Ishiguro, Yosuke Yamamoto, Sho Nishinoaki, Shin-Ichi Ninomiya, Marina Mitsui, Amit S. Kalgutkar, Hiroshi Yamazaki & Hiroshi Suemizu
Pages: 382-393
Published online: 07 Jul 2016
AbstractforSimulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling | Full Text | References | PDF (820 KB)
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Open Access

Clinical Pharmacokinetics and Metabolism

Article
Population pharmacokinetic (PK) analysis of laromustine, an emerging alkylating agent, in cancer patients
Ala F. Nassar, Adam V. Wisnewski & Ivan King
Pages: 394-407
Published online: 20 Jul 2016
AbstractforPopulation pharmacokinetic (PK) analysis of laromustine, an emerging alkylating agent, in cancer patients | Full Text | References | PDF (756.9 KB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Plasma and tissue disposition of florfenicol in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep
Rubén Pérez-Fernández, Victoria Cazanga, Jessie Ana Jeldres, Pedro P. Silva, José Riquelme, Fernando Quiroz, Cristina Palma, Maria D. Carretta & Rafael A. Burgos
Pages: 408-415
Published online: 04 Jul 2016
AbstractforPlasma and tissue disposition of florfenicol in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep | Full Text | References | PDF (310.4 KB)
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Article
Pharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel solution with larotaxel-loaded folate receptor-targeting amphiphilic copolymer-modified liposomes
Xue-Feng Lu, Yang Zhou, Jian Zhang & Guo-Qin Wang
Pages: 416-422
Published online: 20 Jun 2016
AbstractforPharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel solution with larotaxel-loaded folate receptor-targeting amphiphilic copolymer-modified liposomes | Full Text | References | PDF (416.6 KB) | Supplemental
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Molecular Toxicology

Article
Exposure to methyl tert-butyl ether (MTBE) is associated with mitochondrial dysfunction in rat
Arastoo Saeedi, Mahmoud Omidi, Mohammad Javad Khoshnoud & Afshin Mohammadi-Bardbori
Pages: 423-430
Published online: 18 Dec 2015
AbstractforExposure to methyl tert-butyl ether (MTBE) is associated with mitochondrial dysfunction in rat | Full Text | References | PDF (1 MB)
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Article
Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine
Neil Hartman, Hongfei Zhou, Jinzhe Mao, Daniel Mans, Michael Boyne II, Vikram Patel & Thomas Colatsky
Pages: 431-438
Published online: 20 Jun 2016
AbstractforCharacterization of the methemoglobin forming metabolites of benzocaine and lidocaine | Full Text | References | PDF (718 KB)
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Article
Metabolomics analysis of urine from rats administered with long-term, low-dose acrylamide by ultra-performance liquid chromatography-mass spectrometry
Haidan Shi, Liyan Hu, Shuai Chen, Wei Bao, Shuang Yang, Xiujuan Zhao & Changhao Sun
Pages: 439-449
Published online: 27 Jun 2016
AbstractforMetabolomics analysis of urine from rats administered with long-term, low-dose acrylamide by ultra-performance liquid chromatography-mass spectrometry | Full Text | References | PDF (1.5 MB) | Supplemental
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Xenobiotic Transporters

Article
Korean red ginseng extract enhances paclitaxel distribution to mammary tumors and its oral bioavailability by P-glycoprotein inhibition
Jin Kyung Bae, You-Jin Kim, Hee-Sung Chae, Do Yeun Kim, Han Seok Choi, Young-Won Chin & Young Hee Choi
Pages: 450-459
Published online: 17 May 2016
AbstractforKorean red ginseng extract enhances paclitaxel distribution to mammary tumors and its oral bioavailability by P-glycoprotein inhibition | Full Text | References | PDF (417.7 KB)
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Corrigenda

Correction
Correction to: Exposure to methyl tert-butyl ether (MTBE) is associated with mitochondrial dysfunction in rat
Page: x
Published online: 31 Mar 2017
CitationforCorrection to: Exposure to methyl tert-butyl ether (MTBE) is associated with mitochondrial dysfunction in rat | Full Text | PDF (86.9 KB)
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