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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 2
153
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Animal Pharmacokinetics and metabolism

Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism

, , , , &
Pages 211-215 | Received 27 Dec 2017, Accepted 05 Feb 2018, Published online: 06 Mar 2018
 

Abstract

  1. Triptolide and fenofibrate are often used together for the treatment of nephrotic syndrome in Chinese clinics.

  2. This study investigates the effects of triptolide on the pharmacokinetics of fenofibrate in rats and it potential mechanism.

  3. The pharmacokinetics of fenofibrate (20 mg/kg) with or without triptolide pretreatment (2 mg/kg/day for seven days) were investigated. Additionally, the inhibitory effects of triptolide on the metabolic stability of fenofibrate were investigated using rat liver microsome incubation systems.

  4. The results indicated that the Cmax (35.34 ± 7.52 vs. 30.43 ± 6.45 μg/mL), t1/2 (6.17 ± 1.15 vs. 4.90 ± 0.82 h) and AUC(0–t) (468.12 ± 35.84 vs. 416.35 ± 32.68 mg h L−1) of fenofibric acid decreased significantly (p < .05). The Tmax of fenofibric acid increased significantly (p < .05) from 5.12 ± 0.36 to 6.07 ± 0.68 h. Additionally, the metabolic stability of fenofibrate was prolonged from 35.8 ± 6.2 to 48.6 ± 7.5 min (p < .05) with the pretreatment of triptolide.

  5. In conclusion, these results indicated that triptolide could affect the pharmacokinetics of fenofibric acid, possibly by inhibiting the metabolism of fenofibrate in rat liver when they were co-administered.

Disclosure statement

No potential conflict of interest was reported by the authors.

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